Chen, Jie Yang, Hao Feng, Yanru Shi, Qiuxiao Li, Zhao Tao, Ze Fan, Jie Jin, Youmei Li, Shengfu Cheng, Jingqiu
...
Published in
Applied Microbiology and Biotechnology
Abstract Due to their potent immune stimulation, tumor necrosis factor alpha (TNFα) variants with tumor-homing activity are attractive as novel antitumor drugs. The promising antitumor effect of NGR-TNFα in clinical trials triggered extensive interest in developing novel tumor-homing TNFα variants in recent years. Owing to its promising antitumor e...
Maier, Christopher Hofmann, Katharina Huptas, Christopher Scherer, Siegfried Wenning, Mareike Lücking, Genia
Published in
Applied Microbiology and Biotechnology
Abstract The heat-stable peptidase AprX, secreted by psychrotolerant Pseudomonas species in raw milk, is a major cause of destabilization and premature spoilage of ultra-high temperature (UHT) milk and milk products. To enable rapid detection and quantification of seven frequent and proteolytic Pseudomonas species ( P. proteolytica , P. gessardii ,...
Li, Mingyang Shi, Wei Yang, Jia Wang, Qi Dong, Haiyan Chen, Jun Zhang, Lifang Zhu, Shanli
Published in
Applied Microbiology and Biotechnology
Abstract Chlamydia trachomatis ( C. trachomatis ) is the leading cause of preventable blindness worldwide and the most prevalent cause of bacterial sexually transmitted diseases. At present, there is no available vaccine, and recurrences after antibiotics treatment are substantial problems. Major outer membrane protein (MOMP) accounts for 60% of th...
Vortmann, Marina Stumpf, Anna K. Sgobba, Elvira Dirks-Hofmeister, Mareike E. Krehenbrink, Martin Wendisch, Volker F. Philipp, Bodo Moerschbacher, Bruno M.
Published in
Applied Microbiology and Biotechnology
Chitin is an abundant waste product from shrimp and mushroom industries and as such, an appropriate secondary feedstock for biotechnological processes. However, chitin is a crystalline substrate embedded in complex biological matrices, and, therefore, difficult to utilize, requiring an equally complex chitinolytic machinery. Following a bottom-up a...
Soares, Eduardo V. Soares, Helena M. V. M.
Published in
Applied Microbiology and Biotechnology
Abstract The incorporation of nanomaterials (NMs), including metal(loid) oxide (MOx) nanoparticles (NPs), in the most diversified consumer products, has grown enormously in recent decades. Consequently, the contact between humans and these materials increased, as well as their presence in the environment. This fact has raised concerns and uncertain...
Wu, Yixiao Bissinger, Thomas Genzel, Yvonne Liu, Xuping Reichl, Udo Tan, Wen-Song
Published in
Applied Microbiology and Biotechnology
Abstract Similar to the recent COVID-19 pandemic, influenza A virus poses a constant threat to the global community. For the treatment of flu disease, both antivirals and vaccines are available with vaccines the most effective and safest approach. In order to overcome limitations in egg-based vaccine manufacturing, cell culture–based processes have...
Gasmi, Amin Peana, Massimiliano Noor, Sadaf Lysiuk, Roman Menzel, Alain Gasmi Benahmed, Asma Bjørklund, Geir
Published in
Applied Microbiology and Biotechnology
Abstract The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been suggested as promising agents against the new coronavirus SARS-CoV-2 that induces COVID-19 and as a possible therapy for shortening the duration of the viral disease. The antiviral effects of CQ and HCQ have been demonstrated in vitro due to their ability to bl...
Ryngajłło, Małgorzata Boruta, Tomasz Bizukojć, Marcin
Published in
Applied Microbiology and Biotechnology
Abstract In the present study, the complete genome of a filamentous fungus Aspergillus terreus ATCC 20542 was sequenced, assembled, and annotated. This strain is mainly recognized for being a model wild-type lovastatin producer and a parental strain of high-yielding industrial mutants. It is also a microorganism with a rich repertoire of secondary ...
Dimkić, Ivica Fira, Djordje Janakiev, Tamara Kabić, Jovana Stupar, Miloš Nenadić, Marija Unković, Nikola Grbić, Milica Ljaljević
Published in
Applied Microbiology and Biotechnology
Abstract Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, ...
Liao, Yating Luo, Dan Peng, Kailan Zeng, Yanhua
Published in
Applied Microbiology and Biotechnology
Abstract Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cance...
