Wang, Hao Bai, Guangxu Chen, Jianwei Han, Wen Guo, Ran Cui, Na
Published in
Apoptosis
Autophagy dysfunction contributes to CD4 + T cell apoptosis during sepsis leading to impairment of adaptive immunity. However, the underlying mechanism is unclear. The mammalian target of rapamycin (mTOR) pathway modulates CD4 + T cell survival during sepsis through mechanisms that are not fully understood. We developed a mouse model of sepsis thro...
Le, Hien Thi Thu Murugesan, Akshaya Candeias, Nuno R. Ramesh, Thiyagarajan Yli-Harja, Olli Kandhavelu, Meenakshisundaram
Published in
Apoptosis
P2Y receptors belong to the large superfamily of G-protein-coupled receptors and play a crucial role in cell death and survival. P2Y1 receptor has been identified as a marker for prostate cancer (PCa). A previously unveiled selective P2Y1 receptor agonist, the indoline-derived HIC (1-(1-((2-hydroxy-5-nitrophenyl)(4-hydroxyphenyl)methyl)indoline-4-c...
Tripathi, Ashish Kumar Rai, Divya Kothari, Priyanka Kushwaha, Pragati Sashidhara, Koneni V. Trivedi, Ritu
Published in
Apoptosis
Glucocorticoid induced osteoporosis (GIOP) is the second most leading cause of osteoporosis. We have identified a compound, a benzofuran pyran hybrid compound 4e that has osteogenic potential and we wanted to assess its efficacy in GIOP in male mice. We assessed the effect of dexamethasone and compound 4e on primary osteoblasts using various cell b...
Wagener, Nele Buchholz, Malte Bertolino, Philippe Zhang, Chang X Di Fazio, Pietro
Published in
Apoptosis : an international journal on programmed cell death
MEN1 mutation causes pancreatic neuroendocrine neoplasia and benign malignancies of the parathyroid, the adrenal cortex and pituitary gland. The transcriptional activity of its product menin promotes the expression of genes deputed to several cellular mechanism including cell death. Here, we focused on its implication in the activation of the initi...
Dold, Manuel Nico Ng, Xiulin Alber, Claudia Gentle, Ian Edward Häcker, Georg Weber, Arnim
Published in
Apoptosis
Death receptors are transmembrane proteins that can induce the activation of caspase-8 upon ligand binding, initiating apoptosis. Recent work has highlighted the great molecular complexity of death receptor signalling, in particular through ubiquitination/deubiquitination. We have earlier defined the deubiquitinase Ubiquitin-Specific Protease 27x (...
Haeckel, Akvile Ascher, Lena Beindorff, Nicola Prasad, Sonal Garczyńska, Karolina Guo, Jing Schellenberger, Eyk
Published in
Apoptosis
Annexin A5 (anxA5) is a marker for apoptosis, but has also therapeutic potential in cardiovascular diseases, cancer, and, due to apoptotic mimicry, against dangerous viruses, which is limited by the short blood circulation. An 864-amino-acid XTEN polypeptide was fused to anxA5. XTEN864-anxA5 was expressed in Escherichia coli and purified using XTEN...
Moghimi, Negin Eslami Farsani, Bahram Ghadipasha, Masoud Mahmoudiasl, Gholam-Reza Piryaei, Abbas Aliaghaei, Abbas Abdi, Shabnam Abbaszadeh, Hojjat-Allah Abdollahifar, Mohammad-Amin Forozesh, Mehdi
...
Published in
Apoptosis
To evaluate the incidence of apoptosis within the testes of patients who died from severe acute respiratory syndrome coronavirus 2 (COVID-19) complications, testis tissue was collected from autopsies of COVID-19 positive (n = 6) and negative men (n = 6). They were then taken for histopathological experiments, and RNA extraction, to examine the expr...
Ducrey, Eloise Castrogiovanni, Cédric Meraldi, Patrick Nowak-Sliwinska, Patrycja
Published in
Apoptosis : an international journal on programmed cell death
Mitosis, under the control of the microtubule-based mitotic spindle, is an attractive target for anti-cancer treatments, as cancer cells undergo frequent and uncontrolled cell divisions. Microtubule targeting agents that disrupt mitosis or single molecule inhibitors of mitotic kinases or microtubule motors kill cancer cells with a high efficacy. Th...
Abdelwahab, ElHusseiny M M Bovari-Biri, Judit Smuk, Gabor Fillinger, Janos McPhail, Donald Krymskaya, Vera P Pongracz, Judit E
Published in
Apoptosis : an international journal on programmed cell death
Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC mutation leads to continuous activation of the mTOR pathway that requires adaptation to increased ATP requirement. With limited treatment options, there is an increasing demand to identify nove...
Raimondi, Michela Fontana, Fabrizio Marzagalli, Monica Audano, Matteo Beretta, Giangiacomo Procacci, Patrizia Sartori, Patrizia Mitro, Nico Limonta, Patrizia
Published in
Apoptosis : an international journal on programmed cell death
Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptosis in human melanoma cells. Here, we investigated whether it might also activate paraptosis, a non-canonical programmed cell death. In accord...