Yan, Sensen Zhao, Yingzheng Yan, Jingyi Guan, Yabo Lyu, Mengdi Xu, Guangcui Yang, Xuesi Bai, Yichun Yao, Sanqiao
Published in
Antioxidants & redox signaling
Aims: In addition to reducing the respiratory function, crystalline silica (SiO2) disturbs the immune response by affecting immune cells during the progression of silicosis. Regulatory T cell (Treg) differentiation may play a key role in the abnormal polarization of T helper cell (Th)1 and Th2 cells in the development of silicosis-induced fibrosis....
Konieczyńska, Małgorzata Natorska, Joanna Undas, Anetta
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Antioxidants & redox signaling
Significance: Aging is a complex process associated with an increased risk of many diseases, including thrombosis. This review summarizes age-related prothrombotic mechanisms in clinical settings of thromboembolism, focusing on the role of fibrin structure and function modified by oxidative stress. Recent Advances: Aging affects blood coagulation a...
Smyth, Shannon P Nixon, Brett Skerrett-Byrne, David A Burke, Nathan D Bromfield, Elizabeth G
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Antioxidants & redox signaling
Significance: Stringent regulation of protein homeostasis pathways, under both physiological and pathological conditions, is necessary for the maintenance of proteome fidelity and optimal cell functioning. However, when challenged by endogenous or exogenous stressors, these proteostasis pathways can become dysregulated with detrimental consequences...
Hegde, Mangala Girisa, Sosmitha Devanarayanan, Thulasidharan Nair Alqahtani, Mohammed S Abbas, Mohamed Sethi, Gautam Kunnumakkara, Ajaikumar B
Published in
Antioxidants & redox signaling
Zhou, Jiedong Hao, Jinjin Zhong, Zuoquan Yang, Juntao Lv, Tingting Zhao, Bingjie Lin, Hui Chi, Jufang Guo, Hangyuan
Published in
Antioxidants & redox signaling
Aims: The relationship between the gut microbiota and cardiovascular system has been increasingly clarified. Fecal microbiota transplantation (FMT), used to improve gut microbiota, has been applied clinically for disease treatment and has great potential in combating doxorubicin (DOX)-induced cardiotoxicity. However, the application of FMT in the c...
Jiang, Lingxiang Liu, Yingchun Tumbath, Soumya Boudreau, Matthew W Chatkewitz, Lindsay E Wang, Jiangwei Su, Xiaolin Zahid, Kashif Rafiq Li, Katherine Chen, Yaomin
...
Published in
Antioxidants & redox signaling
Aims: Pancreatic cancer is among the top five leading causes of cancer-related deaths worldwide, with poor overall survival rates. Current therapies for pancreatic cancer lack tumor specificity, resulting in harmful effects on normal tissues. Therefore, developing tumor-specific agents for the treatment of pancreatic cancer is critical. NAD(P)H:qui...
Yang, LiJiao Liu, Qing Lu, QianYu Xiao, Jing-Jie Fu, An-Yao Wang, Shan Ni, LiHua Hu, Jun-Wei Yu, Hong Wu, XiaoYan
...
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Antioxidants & redox signaling
Aims: Scavenger receptor class B type I (SRBI) promotes cell cholesterol efflux and the clearance of plasma cholesterol. Thus, SRBI deficiency causes abnormal cholesterol metabolism and hyperlipidemia. Studies have suggested that ferroptosis is involved in lipotoxicity; however, whether SRBI deficiency could induce ferroptosis remains to be investi...
Mishra, Shefali Ganapathi, Thumballi Ramabhatta Pandey, Girdhar Kumar Foyer, Christine Helen Srivastava, Ashish Kumar
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Antioxidants & redox signaling
Liu, Fangfei He, Junlin Chen, Xuemei Liu, Ronglu Li, Fangfang Geng, Yanqing Dai, Yuhan Zhang, Yan Wang, Yingxiong Mu, Xinyi
...
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Antioxidants & redox signaling
Aim: Acetaminophen (APAP) is clinically recommended as analgesic and antipyretic among pregnant women. However, accumulating laboratory evidence shows that the use of APAP during pregnancy may alter fetal development. Since fetal stage is a susceptible window for early oogenesis, we aim to assess the potential effects of maternal administration of ...
Liu, Mingliang Li, Hehe Li, Xiaoling Pan, Boyu Zhang, Jian Pan, Ya Shen, Miaomiao Liu, Liren
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Antioxidants & redox signaling
