Published in Anticancer research
To examine the association between sense of coherence (SOC) and health-related quality of life (HRQoL) in early breast cancer patients. The study population included 406 disease-free breast cancer survivors who participated in 3-year and 5-year follow-ups of a randomized exercise intervention. SOC was assessed using the short version of the Orienta...
Published in Anticancer research
Pharmacological inhibition of osteoclast activity is an essential component of oncological therapy for patients with bone metastases. In rare cases, medication-related osteonecrosis of the jaws (MRONJ) is observed. MRONJ can cause bone defects not inferior to primary or metastatic jaw neoplasms. Oral examination of patients on osteoclast-inhibiting...
Published in Anticancer research
For epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), administration of EGFR tyrosine kinase inhibitors (TKIs) is mandatory to prolong survival. To date, a comparison of second- and third-generation EGFR-TKIs has not been reported as far as we are aware. We retrospectively investigated the survival time of patients...
Published in Anticancer research
The limited efficacy of immune checkpoint inhibitors in colorectal cancer (CRC) is likely due to immunosuppressive mechanisms including T cell exhaustion caused by inhibitory immune checkpoints in the tumor microenvironment. We investigated the expression status of the inhibitory immune checkpoint receptors on tumor-infiltrating T cells and their l...
Published in Anticancer research
To identify the best of three isatin-based scaffolds in terms of anticancer activity. Synthesis of isatin-based scaffolds was performed through a reaction to form Schiff bases. In silico analyses consisted of a target prediction with the Swiss Target Prediction tool and a molecular docking by AutoDock Vina. Anticancer activity and cytotoxicity were...
Published in Anticancer research
Head and neck cancers are often treated with extended courses of radiotherapy (RT), which may prove excessively toxic for frail patients. Split course RT (SCRT) delivers two courses of RT separated by 4-6 weeks, personalizing treatment intensity based on response. In this study, we present our updated experience using this technique. From a single ...
Published in Anticancer research
The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation immunochemical test (FIT) for Hb and Hb/Hp (Biohit Oyj, Helsinki, Finland) in subjects participating in colorectal cancer (CRC) detection in Brazil. A traditional gFOBT test (HemoccultSENSA) was used as a ref...
Published in Anticancer research
This study analyzed the ability of body composition to predict the outcome of patients with metastatic renal cell carcinoma (RCC) who received cytoreductive nephrectomy followed by systemic therapy. A retrospective study was conducted from December 2010 to November 2017 in a single tertiary medical center. The medical charts and computed tomography...
Published in Anticancer research
Investigation of the influence of different ultra-low dose computed tomography (ULDCT) protocols on the detection of solid and subsolid nodules in a phantom study. A chest phantom with pulmonary nodules was scanned with different CT protocols ranging from ultra-low dose settings with spectral shaping to a standard low dose lung cancer screening pro...
Published in Anticancer research
Many patients with prostate cancer receive definitive or adjuvant radiotherapy. This study aimed to identify the frequency of sleep disturbances and corresponding risk factors prior to radiation treatment. Data of 48 patients assigned to local or loco-regional irradiation for prostate cancer were retrospectively analyzed for pre-radiotherapy sleep ...
