Li, Ching-Hao Sun, Kuo-Ting Li, Xin Shih, Liang-Chun Chen, Liang-Yu Yu, Chien-Chih Wang, Yun-Chi Chang, Wen-Shin Tsai, Chia-Wen Li, Chi-Yuan
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Published in
Anticancer research
Oral cancer is of the highest incidence worldwide in Taiwan, and a better marker for personalized therapeutic strategies such as immunotherapies is urgently needed. Interleukin-12 (IL12) is a cytokine that has been reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. The curren...
Jin, Hyeon-Ok Hong, Sung-Eun Kim, Ji-Young Jang, Se-Kyeong Kim, Young-Sun Sim, Ju-Hee Oh, Ac-Chin Kim, Heyjin Hong, Young Jun Lee, Jin-Kyung
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Published in
Anticancer research
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme implicated in serine biosynthesis, and its overexpression has been linked to cancer cell proliferation. Therefore, targeting PSAT1 is considered to be an anticancer strategy. The viability of non-small cell lung cancer (NSCLC) cells was measured by MTT assay. Protein and mRNA expression were det...
Rades, Dirk Glatzel, Esther Werner, Elisa M Bohnet, Sabine
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Anticancer research
Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. This study evaluated the rate of symptomatic pneumonitis and characteristics in these patients. This study included 278 patients irradiated for locally advanced lung cancer between 2016 and 2019. In patients experiencing symptomatic pneumoniti...
Ninomiya, Mizuki Tomino, Takahiro Matono, Rumi Motomura, Takashi Uchiyama, Hideaki Nishizaki, Takashi
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Anticancer research
In order to overcome postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP), we have developed a new simple technique-Clip on Staple method. In Clip on Staple method, pancreatic parenchyma was divided using a stapling device with a stepped-height staple design to make linear compression line, and thereafter, the full length of the...
Weber, Walter Weber, Samuel S
Published in
Anticancer research
Hodgkin's lymphoma (HL) accounts for 1% of cancers and is of largely unknown pathogenesis. This study intended to find clues about potential causes (etiology) of HL through observations on patients and their families. In 37 years of a medical oncology practice in Basel, Switzerland, 36 out of 2201 patients (1.6%) had HL. Etiological information has...
Vinayanuwattikun, Chanida Prakhongcheep, Ornjira Tungsukruthai, Sucharat Petsri, Korrakod Thirasastr, Prapassorn Leelayuwatanakul, Nophol Chanvorachote, Pithi
Published in
Anticancer research
Individualized proper chemotherapy using in vitro drug sensitivity testing has been proposed as a novel therapeutic modality and shown to have better efficacy than empiric chemotherapy. However, issues around establishing a patient-derived cell culture or xenograft, the timing of the testing obtained, and the validity of testing represent major lim...
Čižmáriková, Martina Takáč, Peter Spengler, Gabriella Kincses, Annamária Nové, Márta Vilková, Mária Mojžiš, Ján
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Anticancer research
Development of new potential drugs to overcome multidrug resistance to chemotherapy is a big challenge for cancer treatment. Attention is also given to the natural compounds and their derivatives. The study aimed at evaluating the impact of a new chalcone derivative (1C) on multidrug resistant cell lines, focusing on P-glycoprotein (P-gp, ABCB1) in...
Kim, Go Woon Lee, Dong Hoon Yeon, Soo-Keun Jeon, Yu Hyun Yoo, Jung Lee, Sang Woo Kwon, So Hee
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Anticancer research
Histone deacetylase 6 (HDAC6) is considered as one of the most promising targets in drug development for cancer therapy. Drug resistance is a major cause of treatment failure in many cancers including glioblastoma (GBM), the most lethal malignant tumor. The role of HDAC6 in GBM resistance and its underlying mechanisms have not been well elucidated....
Nakamura, Jiro Furuya, Shinji Hagio, Kotaro Maruyama, Suguru Shiraishi, Kensuke Shimizu, Hiroki Akaike, Hidenori Hosomura, Naohiro Kawaguchi, Yoshihiko Amemiya, Hidetake
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Published in
Anticancer research
Basaloid squamous cell carcinoma of the oesophagus (BSCCE) has poorer prognosis than conventional oesophageal squamous cell carcinoma (ESCC). This study is the first report on highly expressed miRNAs in BSCCE and their target genes. BSCCE and ESCC patients who underwent esophagectomy were selected for this study. Total RNA was extracted from formal...
Tanaka, Hidekazu Kawaguchi, Masaya Shoda, Shinichi Miyoshi, Toshiharu Iwasaki, Ryota Hyodo, Fuminori Mori, Takashi Hara, Akira Tomita, Hiroyuki Matsuo, Masayuki
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Published in
Anticancer research
The aim of this study was to examine whether the Wnt/β-catenin signal activation is a cause of radioresistance in colon cancer by assessing the β-catenin localization and its correlation with cancer stem cells (CSCs). The nuclear levels of β-catenin, the hallmark of Wnt activation, were analyzed in HCT116 and SW480 cells by immunohistochemistry, be...
