Lee, Chiyun Bhakta, Sanjib
Published in
Antibiotics
Tuberculosis (TB) remains a global health emergency, with an estimated 2 billion people infected across the world, and 1.4 million people dying to this disease every year. Many aspects of the causative agent, Mycobacterium tuberculosis , make this disease difficult for healthcare and laboratory researchers to fight against, such as unique pathophys...
Gasperini, Beatrice Cherubini, Antonio Lucarelli, Moira Espinosa, Emma Prospero, Emilia
Published in
Antibiotics
The impact of the COVID-19 pandemic on multidrug-resistant (MDR) bacteria is unknown. The purpose of this study was to assess prevalence, etiology, and association with mortality of MDR bacteria in older adult patients before and after the first peak of the COVID-19 pandemic in Italy. An observational retrospective study was conducted in two geriat...
Kolar, Milan Htoutou Sedlakova, Miroslava Urbanek, Karel Mlynarcik, Patrik Roderova, Magdalena Hricova, Kristyna Mezerova, Kristyna Kucova, Pavla Zapletalova, Jana Fiserova, Katerina
...
Published in
Antibiotics
The article describes activities of an antibiotic center at a university hospital in the Czech Republic and presents the results of antibiotic stewardship program implementation over a period of 10 years. It provides data on the development of resistance of Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa and Staphylococcus aureus ...
Pietsch, Michael Pfeifer, Yvonne Fuchs, Stephan Werner, Guido
Published in
Antibiotics
(1) Background: Resistance plasmids are under selective conditions beneficial for the bacterial host, but in the absence of selective pressure, this carriage may cause fitness costs. Compensation of this fitness burden is important to obtain competitive ability under antibiotic-free conditions. In this study, we investigated fitness effects after a...
Catalano, Alessia Iacopetta, Domenico Pellegrino, Michele Aquaro, Stefano Franchini, Carlo Sinicropi, Maria Stefania
Published in
Antibiotics
Antimicrobials have allowed medical advancements over several decades. However, the continuous emergence of antimicrobial resistance restricts efficacy in treating infectious diseases. In this context, the drug repositioning of already known biological active compounds to antimicrobials could represent a useful strategy. In 2002 and 2003, the SARS-...
Han, Hee-Won Kwak, Jin-Hwan Jang, Tae-Su Knowles, Jonathan Campbell Kim, Hae-Won Lee, Hae-Hyoung Lee, Jung-Hwan
Published in
Antibiotics
Multidrug-resistant (MDR) bacteria are increasing due to the abuse and misuse of antibiotics, and nosocomial infections by MDR bacteria are also increasing. The aim of this study was to identify new substances that can target MDR bacteria among 12 plant extracts that are known to have antibacterial effects. The experiments were performed by the dis...
Rivera-Izquierdo, Mario Láinez-Ramos-Bossini, Antonio Jesús Rivera-Izquierdo, Carlos López-Gómez, Jairo Fernández-Martínez, Nicolás Francisco Redruello-Guerrero, Pablo Martín-delosReyes, Luis Miguel Martínez-Ruiz, Virginia Moreno-Roldán, Elena Jiménez-Mejías, Eladio
...
Published in
Antibiotics
Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classi...
López-Agudelo, Víctor A. Gómez-Ríos, David Ramirez-Malule, Howard
Published in
Antibiotics
Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus ( S. clavuligerus ). CA is typically co-formulated with broad-spectrum β‑lactam antibiotics such as amoxicillin, conferring them high potential to treat diseases caused by bacteria that possess β‑lactam resis...
Frenkel, Nelly Saar Dover, Ron Titon, Eve Shai, Yechiel Rom-Kedar, Vered
Published in
Antibiotics
The outcome of an antibiotic treatment on the growth capacity of bacteria is largely dependent on the initial population size (Inoculum Effect). We characterized and built a model of this effect in E. coli cultures using a large variety of antimicrobials, including conventional antibiotics, and for the first time, cationic antimicrobial peptides (C...
Sakthi Mohan, Priyadarshini Sonsuddin, Faridah Mainal, Azizah Binti Yahya, Rosiyah Venkatraman, Gopinath Vadivelu, Jamuna Al-Farraj, Dunia A. Al-Mohaimeed, Amal M. Alarijani, Khaloud Mohammed
Published in
Antibiotics
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precurs...