Preface
Published in Annual Reports in Medicinal Chemistry
Fundamentals of G-quadruplex biology.
Published in Annual reports in medicinal chemistry
Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes fr...
Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
Published in Annual Reports in Medicinal Chemistry
Viruses are the most abundant organisms on our planet, affecting all living beings: some of them are responsible for massive epidemics that concern health, national economies and the overall welfare of societies. Although advances in antiviral research have led to successful therapies against several human viruses, still some of them cannot be erad...
Antiviral Agents Against Ebola Virus Infection: Repositioning Old Drugs and Finding Novel Small Molecules
Published in Annual Reports in Medicinal Chemistry
Ebola virus (EBOV) causes a deadly hemorrhagic syndrome in humans with mortality rate up to 90%. First reported in Zaire in 1976, EBOV outbreaks showed a fluctuating trend during time and fora long period it was considered a tragic disease confined to the isolated regions of the African continent where the EBOV fear was perpetuated among the poor c...
Idiopathic pulmonary fibrosis
Published in Orphanet Journal of Rare Diseases
Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons worldwide. The prevalence is estimated to be slightly greater in men (20.2/100,000) than in wome...
Preface
Published in Annual Reports in Medicinal Chemistry
Cumulative NCE Introduction Index, 1983–2012
Published in Annual Reports in Medicinal Chemistry
Recent Advances in Small Molecule Target Identification Methods
Published in Annual Reports in Medicinal Chemistry
In this chapter, four major target identification approaches including affinity-based proteomics, in silico target prediction, drug resistance-sequencing, and yeast-based approaches are discussed with demonstrative examples from the last few years.
Targeting the Nuclear Hormone Receptor RORγt for the Treatment of Autoimmune and Inflammatory Disorders
Published in Annual Reports in Medicinal Chemistry
Current therapies for inflammatory and autoimmune diseases include general immuosuppressive agents and newer biologics targeting proinflammatory cytokines. Despite these treatment options, significant unmet medical need remains particularly for more specific targeted agents. Dysregulation of the IL-23/IL-17 pathway is implicated in several inflamma...
Special Challenges to the Rational Design of Antibacterial Agents
Published in Annual Reports in Medicinal Chemistry
The rational design of pharmaceutical agents with activity against bacterial targets presents several unique challenges due to the significant differences in the target bacterial cells and the eukaryotic cells of their mammalian hosts. The structural features and cellular components commonly targeted in drug design programs are often unique to bact...
