Zendel, Benjamin Rich
Published in
Annals of the New York Academy of Sciences
Hearing abilities decline with age, and one of the most commonly reported hearing issues in older adults is a difficulty understanding speech when there is loud background noise. Understanding speech in noise relies on numerous cognitive processes, including working memory, and is supported by numerous brain regions, including the motor and motor p...
Martínez-Molina, Noelia Siponkoski, Sini-Tuuli Särkämö, Teppo
Published in
Annals of the New York Academy of Sciences
Traumatic brain injury (TBI) causes lifelong cognitive deficits, most often in executive function (EF). Both musical training and music-based rehabilitation have been shown to enhance EF and neuroplasticity. Thus far, however, there is little evidence for the potential rehabilitative effects of music for TBI. Here, we review the core findings from ...
Huang, Wanqi Yuan, Zhengwei Gu, Hui
Published in
Annals of the New York Academy of Sciences
Neural tube defects (NTDs) are a heterogeneous set of malformations attributed to disruption in normal neural tube closure during early embryogenesis. An in-depth understanding of NTD etiology and mechanisms remains elusive, however. Among the proposed mechanisms, epigenetic changes are thought to play an important role in the formation of NTDs. Ep...
Srivastava, Ritesh K Wang, Yong Khan, Jasim Muzaffar, Suhail Lee, Madison B Weng, Zhiping Croutch, Claire Agarwal, Anupam Deshane, Jessy Athar, Mohammad
...
Published in
Annals of the New York Academy of Sciences
Arsenical vesicants cause skin inflammation, blistering, and pain. The lack of appropriate animal models causes difficulty in defining their molecular pathogenesis. Here, Ptch1+/- /C57BL/6 mice were employed to investigate the pathobiology of the arsenicals lewisite and phenylarsine oxide (PAO). Following lewisite or PAO challenge (24 h), the skin ...
Scott, Louie Elídóttir, Katrín Jeevaratnam, Kamalan Jurewicz, Izabela Lewis, Rebecca
Published in
Annals of the New York Academy of Sciences
Electrical conductivity is of great significance to cardiac tissue engineering and permits the use of electrical stimulation in mimicking cardiac pacing. The development of biomaterials for tissue engineering can incorporate physical properties that are uncommon to standard cell culture and can facilitate improved cardiomyocyte function. In this re...
Ivanov, Andrei I Lechuga, Susana Marino-Melendez, Armando Naydenov, Nayden G
Published in
Annals of the New York Academy of Sciences
The integrity and functions of epithelial barriers depend on the formation of adherens junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their association with the cortical cytoskeleton composed of actin filaments and nonmuscle myosin II (NM-II) motors. Mechanical forces generated by the actomyosin cytoskeleton a...
Weiß, Franziska Holthaus, David Kraft, Martin Klotz, Christian Schneemann, Martina Schulzke, Jörg D Krug, Susanne M
Published in
Annals of the New York Academy of Sciences
Usually, duodenal barriers are investigated using intestinal cell lines like Caco-2, which in contrast to native tissue are limited in cell-type representation. Organoids can consist of all intestinal cell types and are supposed to better reflect the in vivo situation. Growing three-dimensionally, with the apical side facing the lumen, application ...
Hempel, Caroline Rosenthal, Rita Fromm, Anja Krug, Susanne M Fromm, Michael Günzel, Dorothee Piontek, Jörg
Published in
Annals of the New York Academy of Sciences
Although functional and structural models for paracellular channels formed by claudins have been reported, mechanisms regulating charge and size selectivity of these channels are unknown in detail. Here, claudin-15 and claudin-10b cation channels showing high-sequence similarity but differing channel properties were analyzed. Mutants of pore-lining...
Hunt, Thomas E Maloney, Erin A
Published in
Annals of the New York Academy of Sciences
Math anxiety affects many people, from young children through to older adults. While there has been debate concerning the developmental trajectory of math anxiety and negative math attitudes, little attention has been given to the role of appraisals of previous math experiences. We surveyed 308 adults (mean age = 27.56 years, SD = 11.25) and assess...
Caudwell, Kim M Soranzo, Alessandro Lim, Lee Wei Aquili, Luca
Published in
Annals of the New York Academy of Sciences
Government restrictions to the movement of people due to the COVID-19 pandemic have had a wide range of effects on scientific activity. Here, we show that during the pandemic there has been a reduction in the number of registered non-COVID-19 clinical trials. Furthermore, using the Oxford COVID-19 Government Response Tracker Stringency Index (SI) a...
