Published in Annals of the New York Academy of Sciences
Poorer, hotter countries are more vulnerable to climate change and will experience more negative impacts. The pattern of vulnerability between countries is used to impute impacts for income deciles within countries, for administrative regions, and for grid cells. Almost three-quarters of people will face worse impacts than their country average. Be...
Published in Annals of the New York Academy of Sciences
Even though meteorologists have been aware of atmospheric blocking for more than 100 years, it is a phenomenon still not well forecast or completely understood. Also, while there is not one standard accepted definition, there are some commonalities known about the understanding of blocking behavior. Blocking occurs less often than other destructive...
Published in Annals of the New York Academy of Sciences
We describe symptomatic spinal cord compression associated with pseudohypoparathyroidism (PHP) in a young female patient and reviewed similar cases previously reported in the literature. The characteristics of these cases were analyzed from etiology, clinical subtypes, symptoms, treatment, and prognosis. Neurological examination revealed functional...
Published in Annals of the New York Academy of Sciences
The association between sarcopenia and metabolic syndrome (MetS) has been well established. Nevertheless, the transition process between normal and low muscle mass (LMM) states and the effect of this transition on MetS has been less explored. Our study here examined whether the direction toward or away from LMM alters the risks of MetS. Initially, ...
Published in Annals of the New York Academy of Sciences
Overloading stress-induced condylar cartilage degeneration acts as the main pathologic change in temporomandibular joint osteoarthritis (TMJ-OA). However, the progression of degeneration and the ability for self-repair remain poorly understood. Here, we explored the progression of cartilage degeneration by dividing pathological stages using a stead...
Published in Annals of the New York Academy of Sciences
We employ the approach of Roderick and Farquhar (2011) to assess the sensitivity of runoff (R) given changes in precipitation (P), potential evapotranspiration (Ep ), and other properties that change the partitioning of P (n) by estimating coefficients that predict the weight of each variable in the relative change of R. We use this framework using...
Published in Annals of the New York Academy of Sciences
Macrophage-mediated regulation of chondrocytes plays an important role in promoting temporomandibular joint (TMJ) inflammation. We investigated whether extracellular vesicles (EVs) derived from M1 macrophages (M1-EVs) have a proinflammatory effect on TMJ inflammation and what the associated mechanisms are. In vitro, purified THP-1 cell-derived M1-E...
Published in Annals of the New York Academy of Sciences
The purpose of this study was to investigate the possible use of resveratrol (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and to explore the detailed mechanisms. Application of Res to bone marrow-derived mesenchymal stem cells in vitro promoted survival, inhibited apoptosis, and do...
Published in Annals of the New York Academy of Sciences
Acankoreagenin (ACK, also known as acankoreanogenin and HLEDA) and impressic acid are two lupane-type triterpenes that can be isolated from various Acanthopanax and Schefflera species. They efficiently block activation of the NF-κB signaling pathway and the release of proinflammatory cytokines and/or the action of inflammation mediators (HMGB1, iNO...
Published in Annals of the New York Academy of Sciences
Einstein famously claimed that "the most incomprehensible thing about the universe is that it is comprehensible." This statement suggests that no amount of scientific explanation will suffice to make sense of the bizarre situation of the human mind within the universe. So what are the actual roles of awe and wonder within the framework of contempor...
