Mildon, Alison Lopez de Romaña, Daniel Jefferds, Maria Elena D Rogers, Lisa M Golan, Jenna M Arabi, Mandana
Published in
Annals of the New York Academy of Sciences
Anemia is a major global public health concern with a complex etiology. The main determinants are nutritional factors, infection and inflammation, inherited blood disorders, and women's reproductive biology, but the relative role of each varies between settings. Effective anemia programming, therefore, requires evidence-based, data-driven, contextu...
Chu, Kuan-Yu Wang, Yin-Lin Chen, Jung-Tsu Lin, Chia-Hui Yao, Chung-Chen Jane Chen, Yi-Jane Chen, Huan-Wen Simmer, James P Hu, Jan C-C Wang, Shih-Kai
...
Published in
Annals of the New York Academy of Sciences
Familial tooth agenesis (FTA) is one of the most common craniofacial anomalies in humans. Loss-of-function mutations in PAX9 and WNT10A have been known to cause FTA with various expressivity. In this study, we identified five FTA kindreds with novel PAX9 disease-causing mutations: p.(Glu7Lys), p.(Val83Leu), p.(Pro118Ser), p.(Ser197Argfs*23), and c....
Gordon, Reyna L Martschenko, Daphne O Nayak, Srishti Niarchou, Maria Morrison, Matthew D Bell, Eamonn Jacoby, Nori Davis, Lea K
Published in
Annals of the New York Academy of Sciences
New interdisciplinary research into genetic influences on musicality raises a number of ethical and social issues for future avenues of research and public engagement. The historical intersection of music cognition and eugenics heightens the need to vigilantly weigh the potential risks and benefits of these studies and the use of their outcomes. He...
Cable, Jennifer Sun, Jie Cheon, In Su Vaughan, Andrew E Castro, Italo A Stein, Sydney R López, Carolina B Gostic, Katelyn M Openshaw, Peter J M Ellebedy, Ali H
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Published in
Annals of the New York Academy of Sciences
Respiratory viruses are a common cause of morbidity and mortality around the world. Viruses like influenza, RSV, and most recently SARS-CoV-2 can rapidly spread through a population, causing acute infection and, in vulnerable populations, severe or chronic disease. Developing effective treatment and prevention strategies often becomes a race agains...
Cable, Jennifer Denison, Mark R Kielian, Margaret Jackson, William T Bartenschlager, Ralf Ahola, Tero Mukhopadhyay, Suchetana Fremont, Daved H Kuhn, Richard J Shannon, Ashleigh
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Published in
Annals of the New York Academy of Sciences
Positive-strand RNA viruses have been the cause of several recent outbreaks and epidemics, including the Zika virus epidemic in 2015, the SARS outbreak in 2003, and the ongoing SARS-CoV-2 pandemic. On June 18-22, 2022, researchers focusing on positive-strand RNA viruses met for the Keystone Symposium "Positive-Strand RNA Viruses" to share the lates...
Marchina, Sarah Norton, Andrea Schlaug, Gottfried
Published in
Annals of the New York Academy of Sciences
Patients with large left-hemisphere lesions and post-stroke aphasia often remain nonfluent. Melodic intonation therapy (MIT) may be an effective alternative to traditional speech therapy for facilitating recovery of fluency in those patients. In an open-label, proof-of-concept study, 14 subjects with nonfluent aphasia with large left-hemisphere les...
Cable, Jennifer Saphire, Erica Ollmann Hayday, Adrian C Wiltshire, Timothy D Mousa, Jarrod J Humphreys, David P Breij, Esther C W Bruhns, Pierre Broketa, Matteo Furuya, Genta
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Published in
Annals of the New York Academy of Sciences
Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods to improve upon endogenous antibodies and to design antibodies de novo. On April 27-30, 2022, experts in antibody res...
Chuquichambi, Erick G Vartanian, Oshin Skov, Martin Corradi, Guido B Nadal, Marcos Silvia, Paul J Munar, Enric
Published in
Annals of the New York Academy of Sciences
Evidence dating back a century shows that humans are sensitive to and exhibit a preference for visual curvature. This effect has been observed in different age groups, human cultures, and primate species, suggesting that a preference for curvature could be universal. At the same time, several studies have found that preference for curvature is modu...
Cable, Jennifer Lutolf, Matthias P Fu, Jianping Park, Sunghee Estelle Apostolou, Athanasia Chen, Shuibing Song, Cheng Jack Spence, Jason R Liberali, Prisca Lancaster, Madeline
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Published in
Annals of the New York Academy of Sciences
Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving ste...
Wilby, Robert L Orr, Madeleine Depledge, Duncan Giulianotti, Richard Havenith, George Kenyon, Jamie A Matthews, Tom K R Mears, Stephen A Mullan, Donal J Taylor, Lee
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Published in
Annals of the New York Academy of Sciences
As a global industry, sport makes potentially significant contributions to climate change through both carbon emissions and influence over sustainability practices. Yet, evidence regarding impacts is uneven and spread across many disciplines. This paper investigates the impacts of sport emissions on climate and identifies knowledge gaps. We underto...
