Akamine, Yumiko Sugawara-Kikuchi, Yuka Uno, Tsukasa Shimizu, Tetsuo Miura, Masatomo
Published in
Annals of clinical biochemistry
Background This study developed a novel high-performance liquid chromatography (HPLC) method for the simultaneous quantification of clozapine and its active metabolite, N-desmethylclozapine, in human plasma and investigated the effects of various factors, including genetic polymorphisms in cytochrome P450 (CYP) 2D6, CYP3A5, ABCB1 and ABCG2, on the ...
Saleem, Mohamed Martin, Helen Tolya, Anne Coates, Penny
Published in
Annals of clinical biochemistry
Background Interference from opiates in the Microgenics CEDIA® Buprenorphine assay is known to produce false-positive buprenorphine screening immunoassay results necessitating confirmatory buprenorphine testing by chromatography/mass spectrometry methods. Method We reviewed data on falsely positive buprenorphine immunoassay screen (cut-off ≥ 5 µg/L...
*Rentka, Aniko *Koroskenyi, Krisztina Harsfalvi, Jolan Szekanecz, Zoltan Szucs, Gabriella Szodoray, Peter Kemeny-Beke, Adam
Published in
Annals of clinical biochemistry
The human precorneal tear film is a special body fluid, since it is a complex mixture of proteins, lipids, small bioactive molecules, and their concentrations and relative distribution represent not only the metabolic state of the ocular surface but also the systemic and local homeostasis of the outer eye and the human body. This suggests that bioc...
Jialal, Ishwarlal
Published in
Annals of clinical biochemistry
Hamilton, Paul
Published in
Annals of clinical biochemistry
Murphy, Michael O'Kane, Maurice
Published in
Annals of clinical biochemistry
Griffin, Tomas Patrick Wall, Deirdre Browne, Gerard A Dennedy, Michael C O'Shea, Paula
Published in
Annals of clinical biochemistry
There is a direct positive association between glycaemic control and renin. We advocate for renin measurement to be part of the diabetologist's armamentarium to assess, guide and optimise therapeutic strategies in patients with diabetes.
Shearer, Jasmin L Salmons, Nabeel Murphy, Damian J Gama, Rousseau
Published in
Annals of clinical biochemistry
We report a 70-year-old female presenting with increased libido and mild but rapid onset virilism. Investigations showed markedly elevated androstenedione and 17 hydroxyprogesterone misdirecting to possible late-onset congenital adrenal hyperplasia. High serum testosterone and oestrogens with suppressed gonadotrophins, however, indicated an androge...
Stepien, Karolina Maria Guy, Mark
Published in
Annals of clinical biochemistry
Using the oxidative assay provides a cost-effective means of estimating caeruloplasmin levels. The method is easily adaptable to a 96-well plate format that facilitates high throughput of samples in a busy laboratory. The enzymatic method is more sensitive and specific for differentiating between Wilson's and non-Wilson's when compared to immunoass...
Raffort, Juliette Panaïa-Ferrari, Patricia Lareyre, Fabien Blois, Mathilde Bayer, Pascale Staccini, Pascal Fénichel, Patrick Chinetti, Giulia
Published in
Annals of clinical biochemistry
Background Proglucagon-derived hormones represent a family of peptides mainly produced in the pancreas and the intestine. While several proglucagon-derived peptides play key roles in metabolic diseases, little is known about glicentin. The aim of the present study was to investigate serum glicentin concentrations in individuals with adult obesity a...
