Akamine, Yumiko Sugawara-Kikuchi, Yuka Uno, Tsukasa Shimizu, Tetsuo Miura, Masatomo
Published in
Annals of clinical biochemistry
Background This study developed a novel high-performance liquid chromatography (HPLC) method for the simultaneous quantification of clozapine and its active metabolite, N-desmethylclozapine, in human plasma and investigated the effects of various factors, including genetic polymorphisms in cytochrome P450 (CYP) 2D6, CYP3A5, ABCB1 and ABCG2, on the ...
Saleem, Mohamed Martin, Helen Tolya, Anne Coates, Penny
Published in
Annals of clinical biochemistry
Background Interference from opiates in the Microgenics CEDIA® Buprenorphine assay is known to produce false-positive buprenorphine screening immunoassay results necessitating confirmatory buprenorphine testing by chromatography/mass spectrometry methods. Method We reviewed data on falsely positive buprenorphine immunoassay screen (cut-off ≥ 5 µg/L...
*Rentka, Aniko *Koroskenyi, Krisztina Harsfalvi, Jolan Szekanecz, Zoltan Szucs, Gabriella Szodoray, Peter Kemeny-Beke, Adam
Published in
Annals of clinical biochemistry
The human precorneal tear film is a special body fluid, since it is a complex mixture of proteins, lipids, small bioactive molecules, and their concentrations and relative distribution represent not only the metabolic state of the ocular surface but also the systemic and local homeostasis of the outer eye and the human body. This suggests that bioc...
Jialal, Ishwarlal
Published in
Annals of clinical biochemistry
Hamilton, Paul
Published in
Annals of clinical biochemistry
Murphy, Michael O'Kane, Maurice
Published in
Annals of clinical biochemistry
Quyn, Aaron J Steele, Robert Jc Digby, Jayne Strachan, Judith A Mowat, Craig McDonald, Paula J Carey, Francis A Godber, Ian M Younes, Hakim B Fraser, Callum G
...
Published in
Annals of clinical biochemistry
Background The National Institute for Health and Care Excellence (NICE) published NG12 in 2015. The referral criteria for suspected colorectal cancer (CRC) caused controversy, because tests for occult blood in faeces were recommended. Faecal immunochemical tests for haemoglobin (FIT), which estimate faecal haemoglobin concentrations (f-Hb), might m...
Wang, Hui Bi, Xiaohui Xu, Lei Li, Yirong
Published in
Annals of clinical biochemistry
Background Rheumatoid factor causes positive interference in multiple immunoassays. Recently, negative interference has also been found in immunoassays in the presence of rheumatoid factor. The chemiluminescent microparticle immunoassay is widely used to determine serum alpha-fetoprotein. However, it is not clear whether the presence of rheumatoid ...
Armer, Jane M Allcock, Rebecca L
Published in
Annals of clinical biochemistry
Background Detection of alcohol consumption in clients undergoing treatment for alcohol dependence can be difficult. The ethanol metabolites ethyl glucuronide and ethyl sulphate are detectable for longer in urine than either breath ethanol or urine ethanol. Our aim was to develop a liquid chromatography-tandem mass spectrometry method for urine eth...
Shearer, Jasmin L Salmons, Nabeel Murphy, Damian J Gama, Rousseau
Published in
Annals of clinical biochemistry
We report a 70-year-old female presenting with increased libido and mild but rapid onset virilism. Investigations showed markedly elevated androstenedione and 17 hydroxyprogesterone misdirecting to possible late-onset congenital adrenal hyperplasia. High serum testosterone and oestrogens with suppressed gonadotrophins, however, indicated an androge...
