Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma.
Published in Annals of clinical biochemistry
Serum human epididymis secretory protein 4 correlates with sepsis associated acute respiratory distress syndrome and 28-...
...Published in Annals of clinical biochemistry
Acute respiratory distress syndrome (ARDS) is a severe disease with high mortality, and its primary cause is sepsis. The aim of this study was to detect and evaluate the role of Human epididymis protein 4 (HE4) in sepsis-related ARDS. One hundred and twenty-three critically ill sepsis patients with/without ARDS and 102 healthy controls were enrolle...
A standard addition method to quantify serum lithium by inductively coupled plasma mass spectrometry.
Published in Annals of clinical biochemistry
Therapeutic monitoring of lithium (Li) is important because of its narrow therapeutic range and therapeutic index. Here, the authors present the evaluation of an accurate method for the determination of lithium in serum. Serum samples were diluted with 0.3% ultrapure nitric acid and were spiked with an internal standard germanium (Ge). The Li/Ge ra...
Best practice in statistics: The use of log transformation.
Published in Annals of clinical biochemistry
The log transformation is often used to reduce skewness of a measurement variable. If, after transformation, the distribution is symmetric, then the Welch t-test might be used to compare groups. If, also, the distribution becomes close to normal, then a reference interval might be determined.
Faecal calprotectin is not necessarily required as a screen for significant bowel disease in primary care.
Published in Annals of clinical biochemistry
NICE recommends measurement of faecal haemoglobin (f-Hb) using faecal immunochemical test (FIT) when colorectal cancer is suspected and calprotectin (f-Cal) in the context of inflammatory bowel disease, though neither is disease specific. During the COVID-19 pandemic, f-Hb has been a requirement prior to referral for endoscopy in England; f-Cal is ...
Acid freezes uricolysis in addition to glycolysis: Utility of fluoride-EDTA-citrate tube in the measurement of uric acid...
Published in Annals of clinical biochemistry
In samples from patients administered rasburicase, ex vivo uricolysis leads to spuriously low uric acid results. The manufacturer's recommendation of storing the sample in ice-water until analysis, however, does not fully arrest uricolysis. Since uricase activity is affected by pH and metal chelators, we assessed uricolysis inhibition in sodium flu...
Stability of serum retinol-binding protein at -20⁰C.
Published in Annals of clinical biochemistry
Prealbumin: The clinical utility and analytical methodologies.
Published in Annals of clinical biochemistry
Prealbumin is a small protein which has been widely evaluated as a nutritional and a prognostic marker. The small size and concentration of prealbumin in blood proposes challenges on measuring it with high sensitivity and specificity. Over the years, a number of analytical methodologies have been developed, which may help establish prealbumin as a ...
Health economic evaluations of medical tests: Translating laboratory information into value - A case study example.
Published in Annals of clinical biochemistry
Health-care providers and funders are focused on identifying value in all their services and that includes laboratories. This means that in order to gain a share of scarce resources, laboratory professionals must also understand and assess the value of tests and that includes their economic impact. This can be assessed using health economic modelli...
Monitoring motherhood: Monitoring and optimizing glycaemia in women with pre-existing diabetes in pregnancy.
Published in Annals of clinical biochemistry
Despite recent advances in care, women with diabetes in pregnancy are still at increased risk of multiple pregnancy complications. Offspring exposed to hyperglycaemia in utero also experience long-term health sequelae, affecting neurocognitive and cardiometabolic status. Many of these adverse consequences can be prevented or ameliorated with good m...
