Continuing Clinical Research During Shelter-in-Place.
Published in Annals of neurology
Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis
Published in Annals of Neurology
Objective Recent studies carried out on amyotrophic lateral sclerosis patients suggest that the disease might initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed to test the corticofugal hypothesis of amyotrophic lateral sclerosis experimentally. Methods Sod1 G86R and Fezf2 knockout mouse li...
Multiple Sclerosis Disease‐Modifying Therapies in the COVID‐19 Era
Published in Annals of Neurology
Classification of Facial Expressions for Intended Display of Emotions Using Brain-Computer Interfaces.
Published in Annals of neurology
Facial expressions are important for intentional display of emotions in social interaction. For people with severe paralysis, the ability to display emotions intentionally can be impaired. Current brain-computer interfaces (BCIs) allow for linguistic communication but are cumbersome for expressing emotions. Here, we investigated the feasibility of ...
Report of EEG Finding on Critically Ill Patients with COVID ‐19
Published in Annals of Neurology
In March 2020, we treated a cohort of 26 critically ill hospitalized SARS‐CoV‐2 infected patients who received EEGs to assess unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness. Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorp...
Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease.
...Published in Annals of neurology
We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls (HCs) and tested baseline CSF biomarkers for prediction of clinical decline in PD. Amyloid-β 1 to 42 (Aβ42 ), total tau (t-tau) and phosphorylated tau (p-tau) at the threonine 181 pos...
Non‐Motor Symptoms in Parkinson's Disease are Reduced by Nabilone
...Published in Annals of Neurology
Objective The objective of this study was to assess the efficacy and safety of nabilone, a synthetic tetrahydrocannabinol analogue, as a treatment for non‐motor symptoms (NMS) in Parkinson's disease (PD). Methods This was a phase II placebo‐controlled, double‐blind, parallel‐group, enriched enrollment randomized withdrawal trial conducted at the Me...
Reply to the Letter “COVID‐19‐Associated Encephalopathy and Cytokine‐Mediated Neuroinflammation”
Published in Annals of Neurology
Permeability Measures Predict Hemorrhagic Transformation after Ischemic Stroke
...Published in Annals of Neurology
Objective We sought to examine the diagnostic utility of existing predictors of any hemorrhagic transformation (HT) and compare them with new perfusion imaging permeability measures in ischemic stroke patients receiving alteplase only. Methods A pixel‐based analysis of pretreatment CT perfusion (CTP) was undertaken to define the optimal CTP permeab...
Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
...Published in Annals of Neurology
Objective Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. Methods Middle cerebral artery was occluded for 12...
