Hernandez, Patricia V Chen, Ling Zhang, Ray Jackups, Ronald Nelson, D Michael He, Mai
Published in
Annals of diagnostic pathology
To evaluate if peri-pregnancy timing of a PCR+ test for SARS-CoV-2 RNA affects pregnancy outcomes and placental pathology. This is a retrospective cohort study conducted in a tertiary center. Pregnancy outcomes and placental pathology were compiled for women who tested positive for SARS-CoV-2 RNA from a nasopharyngeal swab assessed by RT-PCR. The p...
Suster, David Tili, Esmerina Nuovo, Gerard J
Published in
Annals of diagnostic pathology
This study compared the immune response in mild versus fatal SARS-CoV2 infection. Forty nasopharyngeal swabs with either productive mild infection (n = 20) or negative for SARS-CoV2 (n = 20) were tested along with ten lung sections from people who died of COVID-19 which contained abundant SARS-CoV2 and ten controls. There was a 25-fold increase in ...
Nuovo, Gerard J. Suster, David Sawant, Dwitiya Mishra, Aditi Michaille, Jean-Jacques Tili, Esmerina
Published in
Annals of Diagnostic Pathology
Pre-existing Alzheimer's disease is a risk factor for severe/fatal COVID-19 and infection by SARS-CoV2 virus has been associated with an increased incidence of un-masked Alzheimer's disease. The molecular basis whereby SARS-CoV2 may amplify Alzheimer's disease is not well understood. This study analyzed the molecular changes in autopsy brain tissue...
Mezache, Louisa Nuovo, Gerard J Suster, David Tili, Esmerina Awad, Hamdy Radwański, Przemysław B Veeraraghavan, Rengasayee
Published in
Annals of diagnostic pathology
Cardiac manifestations are common in severe COVID-19. This study compared the histologic, viral, and molecular findings in cardiac tissue in fatal COVID-19 (n = 11) and controls (n = 11). In situ hybridization (SARS-CoV2 RNA) and immunohistochemistry for viral proteins and the host response were quantified for the samples and compared with qRTPCR a...
Nuovo, Gerard J. Suster, David Awad, Hamdy Michaille, Jean-Jacques Tili, Esmerina
Published in
Annals of Diagnostic Pathology
Hepatic disease is common in severe COVID-19. This study compared the histologic/molecular findings in the liver in fatal COVID-19 ( n = 9) and age-matched normal controls (n = 9); three of the fatal COVID-19 livers had pre-existing alcohol use disorder (AUD). Controls showed a high resident population of sinusoidal macrophages that had variable A...
Rodrigues, Maria Aparecida Marchesan Zornoff, Denise Kobayasi, Renata
Published in
Annals of Diagnostic Pathology
Context The COVID-19 pandemic has forced traditional teaching to be re-structured and delivered online. Objective To analyse medical students' perceptions about the benefits and difficulties of the remote teaching of Pathology during the COVID-19 pandemic. Design A cross-sectional study was performed with an online survey applied to students from t...
Cho, Woo Cheal Gill, Pavandeep Aung, Phyu P Gu, Jun Nagarajan, Priyadharsini Ivan, Doina Curry, Jonathan L Prieto, Victor G Torres-Cabala, Carlos A
Published in
Annals of diagnostic pathology
Digital pathology has become an integral part of pathology education in recent years, particularly during the COVID-19 pandemic, for its potential utility as a teaching tool that augments the traditional 1-to-1 sign-out experience. Herein, we evaluate the utility of whole slide imaging (WSI) in reducing diagnostic errors in pigmented cutaneous lesi...
Felix, Juan C Sheinin, Yuri M Suster, David Ronen, Natali Ratiani, Mariam Vanden Heuvel, Tana Winge, Emilie Patton, Mollie D Rau, Mary J Ge, Linna
...
Published in
Annals of diagnostic pathology
Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness. Lungs of 12 consecutive COVID-19 decedents consented for autopsy were evaluated for gross and histopathologic abnormalities. A complete Ghon "en block" dissection was performed on a...
Nuovo, Gerard J Magro, Cynthia Shaffer, Toni Awad, Hamdy Suster, David Mikhail, Sheridan He, Bing Michaille, Jean-Jacques Liechty, Benjamin Tili, Esmerina
...
Published in
Annals of diagnostic pathology
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 1...
Magro, Cynthia M Mulvey, Justin Kubiak, Jeffrey Mikhail, Sheridan Suster, David Crowson, A Neil Laurence, Jeffrey Nuovo, Gerard
Published in
Annals of diagnostic pathology
The objective of this study was to elucidate the pathophysiology that underlies severe COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV-2 and viral capsid proteins along with the cellular target(s) and host response from twelve autopsies. There were three key findings: 1) high copy infectious virus was limit...