Published in Annals of Biomedical Engineering
The best way to prevent severe head injury when cycling is to wear a bike helmet. To reduce the rate of head injury in cycling, knowing the nature of real-world head impacts is crucial. Reverse engineering real-world bike helmet impacts in a laboratory setting is an alternative to measuring head impacts directly. This study aims to quantify bike he...
Published in Annals of Biomedical Engineering
Early in 2020, the pandemic resulted in an enormous demand for personal protective equipment (PPE), which consists of face masks, face shields, respirators, and gowns. At our institution, at the request of hospital administration, the Lifespan 3D Printing Laboratory spearheaded an initiative to produce reusable N95 masks for use in the hospital set...
Published in Annals of Biomedical Engineering
While lung protective mechanical ventilation (MV) guidelines have been developed to avoid ventilator-induced lung injury (VILI), a one-size-fits-all approach cannot benefit every individual patient. Hence, there is significant need for the ability to provide patient-specific MV settings to ensure safety, and optimise patient care. Model-based appro...
Published in Annals of Biomedical Engineering
Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However,...
Published in Annals of Biomedical Engineering
Although unphysiological wall shear stress (WSS) has become the consensus hemodynamic mechanism for coronary atherosclerosis, the complex biomechanical stimulus affecting atherosclerosis evolution is still undetermined. This has motivated the interest on the contraction/expansion action exerted by WSS on the endothelium, obtained through the WSS to...
Published in Annals of biomedical engineering
Microtubule "dynamic instability," the abrupt switching from assembly to disassembly caused by the hydrolysis of GTP to GDP within the β subunit of the αβ-tubulin heterodimer, is necessary for vital cellular processes such as mitosis and migration. Despite existing high-resolution structural data, the key mechanochemical differences between the GTP...
Published in Annals of Biomedical Engineering
Ultraviolet radiation as a germicide is widely used in the health field and even in domestic hygiene. Here, we propose an improvement in low-cost portable units of filtration for indoor air, which is based on ultraviolet radiation. In the current technology, to carry out an air filtration with a suspension of aerosols in which there is a likely con...
Published in Annals of Biomedical Engineering
Biological electroporation is a process of opening pores in the cell membrane when exposed to intense electric fields. This work provides results for validation of a dynamic model of electroporation on biological tissues. Computational simulations were carried out and results for the electrical current through the tissue and increase of the tissue ...
Published in Annals of Biomedical Engineering
Mechanical testing and constitutive modelling of isolated arterial layers yields insight into the individual layers’ mechanical properties, but per se fails to recapitulate the in vivo loading state, neglecting layer-specific residual stresses. The aim of this study was to develop a testing/modelling framework that integrates layer-specific uniaxia...
Published in Annals of Biomedical Engineering
This paper focuses on an important issue of disease progression of COVID-19 (coronavirus disease 2019) through processing COVID-19 cough sounds by proposing a fully-automated method. The new method is based on time-domain exploiting only phase 1 data which is always available for any cough events. The proposed approach generates plausible click seq...
