Chen, Weihua Sun, Zhen Lu, Lehui
Published in
Angewandte Chemie (International ed. in English)
Severe side effects and poor therapeutic efficacy are the main drawbacks of current anticancer drugs. These problems can be mitigated by targeting, but the targeting efficacy of current drugs is poor and urgently needs improvement. Taking this into consideration, this Review first summarizes the current targeting strategies for cancer therapy in te...
Hollmann, Frank Opperman, Diederik J Paul, Caroline E
Published in
Angewandte Chemie (International ed. in English)
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describ...
Liu, Jingjuan Song, Xiaoyu Zhang, Ting Liu, Shiyong Wen, Herui Chen, Long
Published in
Angewandte Chemie (International ed. in English)
Two-dimensional conductive metal-organic frameworks (2D c-MOFs) as an emerging class of multifunctional materials have attracted extensive attention due to their predictable and diverse structures, intrinsic permanent porosity, high charge mobility, and excellent electrical conductivity. Such unique characteristics render them as a promising new pl...
Kolpashchikov, Dmitry M Spelkov, Alexander A
Published in
Angewandte Chemie (International ed. in English)
This Minireview discusses the design and applications of binary (also known as split) light-up aptameric sensors (BLAS). BLAS consist of two RNA or DNA strands and a fluorogenic organic dye added as a buffer component. When associated, the two strands form a dye-binding site, followed by an increase in fluorescence of the aptamer-bound dye. The des...
Chen, Jiajie Zhu, Yufang Kaskel, Stefan
Published in
Angewandte Chemie (International ed. in English)
Porphyrins and porphyrin derivatives have been widely explored for various applications owing to their excellent photophysical and electrochemical properties. However, inherent shortcomings, such as instability and self-quenching under physiological conditions, limit their biomedical applications. In recent years, metal-organic frameworks (MOFs) ha...
Sun, Zhe He, Ya Xiong, Banglun Chen, Shanshan Li, Meng Zhou, Yongli Zheng, Yujie Sun, Kuan Yang, Changduk
Published in
Angewandte Chemie (International ed. in English)
The emerging energy crisis has focused significant worldwide attention on solar cells. Although crystalline silicon solar cells are currently widely used, their high cost limits the development of solar power generation. Consequently, hybrid solar cells are becoming increasingly important, especially organic-Si hybrid solar cells (HSCs). Organic-Si...
Gardner, Sarah H Reinhardt, Christopher J Chan, Jefferson
Published in
Angewandte Chemie (International ed. in English)
Until recently, there were no generalizable methods for assessing the effects of post-translational regulation on enzymatic activity. Activity-based sensing (ABS) has emerged as a powerful approach for monitoring small-molecule and enzyme activities within living systems. Initial examples of ABS were applied for measuring general enzymatic activity...
Zhao, Chang-Xin Li, Bo-Quan Liu, Jia-Ning Zhang, Qiang
Published in
Angewandte Chemie (International ed. in English)
Single-atom catalysts (SACs) with highly active sites atomically dispersed on substrates exhibit unique advantages regarding maximum atomic efficiency, abundant chemical structures, and extraordinary catalytic performances for multiple important reactions. In particular, M-N-C SACs (M=transition metal atom) demonstrate optimal electrocatalytic acti...
Rulíšek, Lubomír Smola, Miroslav Gutten, Ondrej Dejmek, Milan Kožíšek, Milan Evangelidis, Thomas Tehrani, Zahra Aliakbar Novotná, Barbora Nencka, Radim Birkuš, Gabriel
...
Published in
Angewandte Chemie (International ed. in English)
STING (stimulator of interferon genes) is a key regulator of innate immunity that has recently been recognized as a promising drug target. STING is activated by cyclic dinucleotides (CDNs) which eventually leads to expression of type I interferons and other cytokines. Factors underlying the affinity of various CDN analogues are poorly understood. H...
Achazi, Katharina Haag, Rainer Ballauff, Matthias Dernedde, Jens Kizhakkedathu, Jayachandran N Maysinger, Dusica Multhaup, Gerd
Published in
Angewandte Chemie (International ed. in English)
The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may dissociate in water and greatly influence the interaction of such polyelectrolytes with biomolecules, particularly proteins. In this Review we give an overview of studies on the interaction of proteins with polyelectrolytes and how this knowledge can be used for...
