Zigon, Nicolas Duplan, Vincent Wada, Naoki Fujita, Makoto
Published in
Angewandte Chemie (International ed. in English)
This Review discusses, along with the historical background, the principles as well as proof-of-concept studies of the crystalline sponge (CS) method, a new single-crystal X-ray diffraction (SCXRD) method for the analysis of the structures of small molecules without sample crystallization. The method uses single-crystalline porous coordination netw...
Anderson, Joseph M Measom, Nicholas D Murphy, John A Poole, Darren L
Published in
Angewandte Chemie (International ed. in English)
"Escaping from flatland", by increasing the saturation level and three-dimensionality of drug-like compounds, can enhance their potency, selectivity and pharmacokinetic profile. One approach that has attracted considerable recent attention is the bioisosteric replacement of aromatic rings, internal alkynes and tert-butyl groups with bicyclo[1.1.1]p...
Xiong, Ping Zhang, Leyuan Chen, Yuyue Peng, Sangshan Yu, Guihua
Published in
Angewandte Chemie (International ed. in English)
Redox flow batteries (RFBs) are among the most promising grid-scale energy storage technologies. However, the development of RFBs with high round-trip efficiency, high rate capability, and long cycle life for practical applications is highly restricted by the lack of appropriate ion-conducting membranes. Promising RFB membranes should separate posi...
Tipker, Ryan M Muldoon, Jake A Pham, Daniel H Varga, Balazs R Hughes, Russell P Glueck, David S Balaich, Gary J Rheingold, Arnold L
Published in
Angewandte Chemie (International ed. in English)
Tetrahedral main group compounds are normally configurationally stable, but P-epimerization of the chiral phosphiranium cations syn - or anti -[Mes*P(Me)CH2CHPh][OTf] (Mes* = 2,4,6-(t-Bu)3C6H2) occurred under mild conditions at 60 °C in CD2Cl2 , resulting in isomerization to give a syn -enriched equilibrium mixture. Ion exchange with excess [NBu4 ]...
Qing, Feng-Ling Ouyang, Yao Xu, Xiu-Hua
Published in
Angewandte Chemie (International ed. in English)
Trifluoromethoxylated aromatics (ArOCF 3 ) are valuable structural motifs in the area of drug discovery due to the enhancement of the desired physicochemical properties upon the introduction of the trifluoromethoxy group (CF 3 O). Although significant progress has been made recently in the introduction of CF 3 O group into aromatics, current method...
Zhang, Lei Wang, Zhaohui Wen, Jingjing Qiu, Fei Liu, Han Liu, Xinyue Hu, Hui Duan, Yuxiao
Published in
Angewandte Chemie (International ed. in English)
We report a facile and powerful strategy to prepare libraries of oligothienoacene diimides that include anti- and syn-isomers using palladium-catalyzed C-H activation and an unexpected 1,2-sulfur migration. Through this strategy, a series of oligothienoacene diimides containing 6, 8, and 10 fused rings were synthesized. The molecular geometry and e...
Smedley, Christopher J Homer, Joshua A Gialelis, Timothy L Barrow, Andrew S Koelln, Rebecca A Moses, John Edward
Published in
Angewandte Chemie (International ed. in English)
SuFEx click chemistry is a powerful method designed for the selective, rapid and modular synthesis of functional molecules. Classical SuFEx reactions form stable S-O linkages upon exchange of S-F bonds with aryl silyl-ether substrates, and while near-perfect in their outcome, are sometimes disadvantaged by relatively high catalyst loadings and prol...
Silalahi, Rhone P Brocha Wang, Qi Liao, Jian-Hong Chiu, Tzu-Hao Wu, Ying-Yann Wang, Xiaoping Kahlal, Samia Saillard, Jean-Yves Liu, Chen-Wei
Published in
Angewandte Chemie (International ed. in English)
In sharp contrast to that of surface hydrides, reactivities on interstitial hydrides are difficult to explore. When treated with a metal ion (Cu + , Ag + , and Au + ), the stable Cu(I) dihydride template [Cu 11 H 2 {S 2 P(O i Pr) 2 } 6 (C≡CPh) 3 ] ( H 2 Cu 11 ) generates surprisingly three very different compounds; namely [CuH 2 Cu 11 {S 2 P(O i Pr...
Xing, Wei Kong, Dongqing Cai, Tonghui Fan, Haodong Hu, Haoyu Wang, Xiaohui Cui, Yongpeng Wang, Dandan Wang, Yesheng Hu, Han
...
Published in
Angewandte Chemie (International ed. in English)
As an emerging post-lithium battery technology, aluminum ion batteries (AIBs) have the advantages of large Al reserves and high safety, and have great potential to be applied to power grid energy storage. But current graphite cathode materials are limited in charge storage capacity due to the formation of stage-4 graphite-intercalated compounds (GI...
Stucki, Ariane Vallapurackal, Jaicy Ward, Thomas R Dittrich, Petra S
Published in
Angewandte Chemie (International ed. in English)
Evolution is essential to the generation of complexity and ultimately life. It relies on the propagation of the properties, traits, and characteristics that allow an organism to survive in a challenging environment. It is evolution that shaped our world over about four billion years by slow and iterative adaptation. While natural evolution based on...
