Deng, Yifeng Lin, Zhenpeng Cheng, Yuan
Published in
Analytical and bioanalytical chemistry
The discovery of small biomolecules has suffered from the lack of a comprehensive framework to express the intrinsic correlation between bioactivity and the contribution from small molecules in complex samples with molecular and bioactivity diversity. Here, by mapping a sample's 2D-HPTLC fingerprint to microplates, paired chromatographic-based micr...
Alexandridou, Anastasia Volmer, Dietrich A
Published in
Analytical and bioanalytical chemistry
The determination of vitamin D metabolites as status marker or for diagnostic purposes is almost entirely conducted from blood serum or plasma. Other biological matrices, however, have also interested researchers, for two main reasons: (1) alternative matrices may allow non-invasive sampling, permit easier sample transfer and require less demanding...
Nemčeková, Katarína Svitková, Veronika Sochr, Jozef Gemeiner, Pavol Labuda, Ján
Published in
Analytical and bioanalytical chemistry
The ability of silver nanoparticles (AgNPs) to be used as drug nanocarriers has helped rapidly to invent novel strategies to treat diseases, such as cancer. The nanoparticles may offer a valuable tool to novel pH-sensitive drug delivery systems in the present scenario because of their undergoing mechanisms associated with the regulated dissolution,...
Sloan-Dennison, Sian O'Connor, Emma Dear, James W Graham, Duncan Faulds, Karen
Published in
Analytical and bioanalytical chemistry
The rapid detection of biomolecules in a point of care (POC) setting is very important for diagnostic purposes. A platform which can provide this, whilst still being low cost and simple to use, is paper-based lateral flow immunoassays (LFIA). LFIA combine immunology and chromatography to detect a target by forming an immunocomplex with a label whic...
Schleicher, Sarah Horoba, Dominik Krafzig, Philip Mischnick, Petra
Published in
Analytical and bioanalytical chemistry
The hydroxyethyl substitution along and among the polymer chains of respective cellulose ethers (HEC and HEMC) can be analyzed by ESI-IT-MS after permethylation of the free OH-groups, partial hydrolysis, and mABA labeling. This method requires the correct quantification of the molar ratios of the constituents belonging to a particular degree of pol...
Carota, Angela Gilda Campanella, Beatrice Del Carratore, Renata Bongioanni, Paolo Giannelli, Roberta Legnaioli, Stefano
Published in
Analytical and bioanalytical chemistry
Raman spectroscopy is an emerging tool in the research and diagnosis of different diseases, including neurodegenerative disorders. In this work, blood serum samples collected from healthy controls and dementia patients were analysed by Raman spectroscopy to develop a classification model for the diagnosis of dementia of Alzheimer's type (DAT). Rama...
Smithers, Jared P Hayes, Mark A
Published in
Analytical and bioanalytical chemistry
The development of elegant and numerous microfluidic manipulations has enabled significant advances in the processing of small volume samples and the detection of minute amounts of biomaterials. Effective isolation of single cells in a defined volume as well as manipulations of complex bioparticle or biomolecule mixtures allows for the utilization ...
Qin, Shanshan Chen, Xuliang Xu, Zhichen Li, Tao Zhao, Shuhong Hu, Rui Zhu, Jiang Li, Ying Yang, Yunhuang Liu, Maili
...
Published in
Analytical and Bioanalytical Chemistry
Few reports are found working on the features and functions of the human telomere G-triplex (ht-G3) though the telomere G-quadruplex has been intensely studied and widely implemented to develop various biosensors. We herein report that ht-G3 lights up Thioflavin T (ThT) and establish a sensitive biosensing platform for RNA detection by introducing ...
Choi, Moon Hyeok Kumara, Guralamatta Siddappa Ravi Lee, Jaehyeon Seo, Young Jun
Published in
Analytical and Bioanalytical Chemistry
In this paper, we report a molecular diagnostic system—combining a colorimetric probe ( RHthio-CuSO 4 ) for pyrophosphate sensing and isothermal gene amplification (ramified rolling circle amplification)—that operates with high selectivity and sensitivity for clinical point-of-care diagnosis of SARS-CoV-2. During the polymerase phase of the DNA amp...
Oberbeckmann-Winter, Nicola
Published in
Analytical and Bioanalytical Chemistry
