Published in Analytical and bioanalytical chemistry
Testing multiple biomarkers, as opposed to one, has become a preferred approach for diagnosing many heterogeneous diseases, such as cancer and infectious diseases. However, numerous technologies, including gold standard ELISA and PCR, can detect only one type of biomarker, either protein or nucleic acid (NA), respectively. In this work, we report f...
Published in Analytical and Bioanalytical Chemistry
Published in Analytical and Bioanalytical Chemistry
Published in Analytical and Bioanalytical Chemistry
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a serious threat to human health all over the world. The development of effective vaccines has been focusing on the spike (S) glycoprotein, which mediates viral invasion to human cells through its interaction with the ang...
Published in Analytical and Bioanalytical Chemistry
Published in Analytical and bioanalytical chemistry
Micro- and nanoplastic contamination is becoming a growing concern for environmental protection and food safety. Therefore, analytical techniques need to produce reliable quantification to ensure proper risk assessment. Raman microspectroscopy (RM) offers identification of single particles, but to ensure that the results are reliable, a certain num...
Published in Analytical and Bioanalytical Chemistry
Nucleic acid detection technology based on polymerase chain reaction (PCR) and antibody detection based on immunochromatography still have many problems such as false negatives for the diagnosis of coronavirus disease 2019 (COVID-19). Therefore, it is of great importance to develop new techniques to improve the diagnostic accuracy of COVID-19. We h...
Published in Analytical and Bioanalytical Chemistry
A fast PCR-assisted impedimetric biosensor was developed for the selective detection of the clbN gene from the polyketide synthase ( pks ) genomic island in real Escherichia coli samples. This genomic island is responsible for the production of colibactin, a harmful genotoxin that has been associated with colorectal cancer. The experimental protoco...
Published in Analytical and Bioanalytical Chemistry
Cutaneous leishmaniasis (CL) is one of the illnesses caused by Leishmania parasite infection, which can be asymptomatic or severe according to the infecting Leishmania strain. CL is commonly diagnosed by directly detecting the parasites or their DNA in tissue samples. New diagnostic methodologies target specific proteins (biomarkers) secreted by th...
Published in Analytical and Bioanalytical Chemistry
Nucleic acid aptamers are small fragments of DNA or RNA molecules binding specifically to targets, which can be obtained through in vitro screening via systematic evolution of ligands by exponential enrichment (SELEX). Lactate dehydrogenase (LDH) is an important tumor marker, whose level in patients is of great significance for diagnosis of many di...
