Solution to bisphenol A measurement challenge
Published in Analytical and Bioanalytical Chemistry
Data averaging challenge
Published in Analytical and Bioanalytical Chemistry
Recent (2018-2020) development in capillary electrophoresis.
Published in Analytical and bioanalytical chemistry
Development of new capillary electrophoresis (CE) methodology and instrumentation, as well as application of CE to solve new problems, remains an active research area because of the attractive features of CE compared to other separation techniques. In this review, we focus on the representative works about sample preconcentration, separation media ...
Chemiluminescent magnetic nanoparticles with good catalytic activity and rapid separation capability and sensitive sensi...
Published in Analytical and bioanalytical chemistry
It is of considerable importance to develop chemiluminescent functionalized nanomaterials (CF-NMs) with good catalytic activity, high chemiluminescence (CL) efficiency and good stability, and rapid magnetic separation capability, achieving excellent performance in CL biosensing. In this study, N-(4-aminobutyl)-N-ethylisoluminol (ABEI)-functionalize...
Specific and sensitive detection of Influenza A virus using a biotin-coated nanoparticle enhanced immunomagnetic assay.
Published in Analytical and bioanalytical chemistry
This study reports the development of a sensitive magnetic bead-based enzyme-linked immunoassay (MELISA) for the pan-reactive detection of the Influenza A virus. The assay combines immunomagnetic beads and biotin-nanoparticle-based detection to quantify a highly conserved viral nucleoprotein in virus lysates. At the capture step, monoclonal antibod...
Utilizing liquid chromatography, ion mobility spectrometry, and mass spectrometry to assess INLIGHT™ derivatized N-linke...
Published in Analytical and bioanalytical chemistry
Glycosylation is a ubiquitous co- and post-translational modification involved in the sorting, folding, and trafficking of proteins in biological systems; in humans, >50% of gene products are glycosylated with the cellular machinery of glycosylation compromising ~2% of the genome. Perturbations in glycosylation have been implicated in a variety of ...
Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices.
Published in Analytical and bioanalytical chemistry
Microfluidic devices can provide a versatile, cost-effective platform for disease diagnostics and risk assessment by quantifying biomarkers. In particular, simultaneous testing of several biomarkers can be powerful. Here, we critically review work from the previous 4 years up to February 2021 on developing microfluidic devices for multiplexed detec...
The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors.
...Published in Analytical and bioanalytical chemistry
Point-of-care (POC) technologies and testing programs hold great potential to significantly improve diagnosis and disease surveillance. POC tests have the intrinsic advantage of being able to be performed near the patient or treatment facility, owing to their portable character. With rapid results often in minutes, these diagnostic platforms have a...
Heterogeneity of SARS-CoV-2 virus produced in cell culture revealed by shotgun proteomics and supported by genome sequen...
...Published in Analytical and bioanalytical chemistry
COVID-19 is the most disturbing pandemic of the past hundred years. Its causative agent, the SARS-CoV-2 virus, has been the subject of an unprecedented investigation to characterize its molecular structure and intimate functioning. While markers for its detection have been proposed and several diagnostic methodologies developed, its propensity to e...
Simultaneous enrichment and separation of neutral and sialyl glycopeptides of SARS-CoV-2 spike protein enabled by dual-f...
Published in Analytical and bioanalytical chemistry
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a serious threat to human health all over the world. The development of effective vaccines has been focusing on the spike (S) glycoprotein, which mediates viral invasion to human cells through its interaction with the ang...
