Solution to Phosphine NMR challenge
Published in Analytical and Bioanalytical Chemistry
“Never odd or even” challenge
Published in Analytical and Bioanalytical Chemistry
Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system
Published in Analytical and Bioanalytical Chemistry
The kallikrein-kinin system (KKS) is involved in many physiological and pathophysiological processes and is assumed to be connected to the development of clinical symptoms of angioedema or COVID-19, among other diseases. However, despite its diverse role in the regulation of physiological and pathophysiological functions, knowledge about the KKS in...
Evaluation of CRISPR/Cas9 site-specific function and validation of sgRNA sequence by a Cas9/sgRNA-assisted reverse PCR t...
...Published in Analytical and Bioanalytical Chemistry
The effective application of the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system in biology, medicine and other fields is hindered by the off-target effects and loci-affinity of Cas9-sgRNA, especially at a genome-wide scale. In order to eliminate the occurrence of off-target effects and evaluate loci-affinity by CRISPR...
The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors
...Published in Analytical and Bioanalytical Chemistry
Point-of-care (POC) technologies and testing programs hold great potential to significantly improve diagnosis and disease surveillance. POC tests have the intrinsic advantage of being able to be performed near the patient or treatment facility, owing to their portable character. With rapid results often in minutes, these diagnostic platforms have a...
Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach
Published in Analytical and Bioanalytical Chemistry
Traditional Chinese medicines played an important role in the treatment of COVID-19 in 2020. Ephedra sinica , one of the major constituent herbs of multi-component herbal formula, has been widely used to treat COVID-19 in China. However, its active components are still unclear. The objectives of this study are to screen and evaluate active componen...
A rapid Soxhlet and mini-SPE method for analysis of polycyclic aromatic hydrocarbons in atmospheric particles
Published in Analytical and Bioanalytical Chemistry
An analytical method was validated with two reference materials of polycyclic aromatic hydrocarbons in atmospheric particles. Standard reference materials (SRMs) were incorporated into the matrix of unexposed cut quartz filters. The methodology was previously designed and extraction of polycyclic aromatic hydrocarbons (PAHs) from fortified filters ...
Recent trends in smartphone-based detection for biomedical applications: a review
Published in Analytical and Bioanalytical Chemistry
Smartphone-based imaging devices (SIDs) have shown to be versatile and have a wide range of biomedical applications. With the increasing demand for high-quality medical services, technological interventions such as portable devices that can be used in remote and resource-less conditions and have an impact on quantity and quality of care. Additional...
Non-competitive fluorescence polarization immunoassay for detection of H5 avian influenza virus using a portable analyze...
...Published in Analytical and Bioanalytical Chemistry
Nowadays, the diagnosis of viral infections is receiving broad attention. We have developed a non-competitive fluorescence polarization immunoassay (NC-FPIA), which is a separation-free immunoassay, for a virus detection. H5 subtype avian influenza virus (H5-AIV) was used as a model virus for the proof of concept. The fluorescein-labeled Fab fragme...
Quality assessment of environmental water by a simple and fast non-ionic hydrophobic natural deep eutectic solvent-based...
Published in Analytical and Bioanalytical Chemistry
A non-ionic hydrophobic natural deep eutectic solvent (HNADES) based on thymol and menthol was proposed for the liquid-liquid microextraction of fourteen phthalates and one adipate from environmental water samples. Separation, identification, and quantification were achieved by ultra-high-performance liquid chromatography coupled to tandem mass spe...
