Rapid and sensitive triple-mode detection of causative SARS-CoV-2 virus specific genes through interaction between genes...
Published in Analytica Chimica Acta
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Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by sing...
Published in Analytica chimica acta
Metabolic analysis in animals is usually either evaluated as whole-body measurements or in isolated tissue samples. To reveal tissue specificities in vivo, this study uses scanning electrochemical microscopy (SECM) to provide localized oxygen consumption rates (OCRs) in different regions of single adult Caenorhabditis elegans individuals. This is a...
A novel One-pot rapid diagnostic technology for COVID-19
...Published in Analytica Chimica Acta
Novel coronavirus disease (COVID-19) caused by SARS-CoV-2 is an ongoing global pandemic associated with high rates of morbidity and mortality. RT-qPCR has become the diagnostic standard for the testing of SARS-CoV-2 in most countries. COVID-19 diagnosis generally relies upon RT-qPCR-mediated identification of SARS-CoV-2 viral RNA, which is costly, ...
The faecal metabolome in COVID-19 patients is altered and associated with clinical features and gut microbes
Published in Analytica Chimica Acta
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Interconnectable solid-liquid protein extraction unit and chip-based dilution for multiplexed consumer immunodiagnostics...
Published in Analytica Chimica Acta
• 1 min allergen protein extraction via disposable homogenizer and 3D-printed sieves . • 3D-printed unibody lab-on-a-chip (ULOC) for on-chip bioreagent storage and dilution . • Pipette-free sample dilution and transport to multiplex immunosensor . • Realtime smartphone analysis using 3D-printed device holder as a lightbox . • Interconnectable and m...
A critical review of point-of-care diagnostic technologies to combat viral pandemics
Published in Analytica Chimica Acta
• Despite decades of research, no products can to meet the testing needs of a pandemic. • We propose new guidelines for the design of point-of-care tests for pandemics. • We summarize the literature on point-of-care diagnostics for pandemics. • We find that sample preparation steps are the primary hindrance to deployment. • We provide a list of rec...
Multiplex and visual detection of African Swine Fever Virus (ASFV) based on Hive-Chip and direct loop-mediated isotherma...
...Published in Analytica Chimica Acta
• Hive-Chip firstly realized simultaneous detection of multiple genes of ASFV, largely avoiding false-negative results. • Without nucleic acid extraction, direct LAMP was firstly incorporated into the Hive-Chip for visual detection. • Because very little operation and no complicate instrument is required, on-site detection is possible for this plat...
Recent advances in analytical strategies for mass spectrometry-based lipidomics
Published in Analytica Chimica Acta
• Recent advances in analytical techniques allow rapid, reliable and sensitive detection of hundreds to thousands of lipids • The diversified MS-based analytical strategies have greatly enhanced the development and application of lipidomics. • The integration of multi-omics has a bright prospect in studying the pathogenesis and potentially targetab...
An LC-MRM assay for the quantification of metanephrines from dried blood spots for the diagnosis of pheochromocytomas an...
Published in Analytica Chimica Acta
• Development and validation of an assay for metanephrines from dried blood spots. • Method utilizes on-spot derivatization followed by LC-MRM-MS based quantitation. • Method demonstrated high degree of sensitivity, precision, and accuracy. • High relevance for the clinical diagnosis of pheochromocytomas and paragangliomas.
Microfluidic-RT-LAMP chip for the point-of-care detection of emerging and re-emerging enteric coronaviruses in swine
...Published in Analytica Chimica Acta
• Microfluidic chip and LAMP were firstly integrated for high-throughput and multitarget detection of PEDV, PDCoV and SADS-CoV. • The microfluidic-RT-LAMP chip system established greatly facilitated the rapid diagnosis of the PEDV, PDCoV and SADS-CoV. • The microfluidic chip device provides excellent prospects in swine enteric coronaviruses surveil...
