Published in Analytica chimica acta
Although SARS-CoV-2 can invade the intestine, though its effect on digestion and absorption is not fully understood. In the present study, 56 COVID-19 patients and 47 age- and sex-matched healthy subjects were divided into a discovery cohort and a validation cohort. Blood, faeces and clinical information were collected from the patients in the hosp...
Published in Analytica Chimica Acta
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Published in Analytica chimica acta
Metabolic analysis in animals is usually either evaluated as whole-body measurements or in isolated tissue samples. To reveal tissue specificities in vivo, this study uses scanning electrochemical microscopy (SECM) to provide localized oxygen consumption rates (OCRs) in different regions of single adult Caenorhabditis elegans individuals. This is a...
Published in Analytica Chimica Acta
Novel coronavirus disease (COVID-19) caused by SARS-CoV-2 is an ongoing global pandemic associated with high rates of morbidity and mortality. RT-qPCR has become the diagnostic standard for the testing of SARS-CoV-2 in most countries. COVID-19 diagnosis generally relies upon RT-qPCR-mediated identification of SARS-CoV-2 viral RNA, which is costly, ...
Published in Analytica Chimica Acta
• 1 min allergen protein extraction via disposable homogenizer and 3D-printed sieves . • 3D-printed unibody lab-on-a-chip (ULOC) for on-chip bioreagent storage and dilution . • Pipette-free sample dilution and transport to multiplex immunosensor . • Realtime smartphone analysis using 3D-printed device holder as a lightbox . • Interconnectable and m...
Published in Analytica Chimica Acta
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Published in Analytica Chimica Acta
• Hive-Chip firstly realized simultaneous detection of multiple genes of ASFV, largely avoiding false-negative results. • Without nucleic acid extraction, direct LAMP was firstly incorporated into the Hive-Chip for visual detection. • Because very little operation and no complicate instrument is required, on-site detection is possible for this plat...
Published in Analytica Chimica Acta
• Recent advances in analytical techniques allow rapid, reliable and sensitive detection of hundreds to thousands of lipids • The diversified MS-based analytical strategies have greatly enhanced the development and application of lipidomics. • The integration of multi-omics has a bright prospect in studying the pathogenesis and potentially targetab...
Published in Analytica Chimica Acta
• Development and validation of an assay for metanephrines from dried blood spots. • Method utilizes on-spot derivatization followed by LC-MRM-MS based quantitation. • Method demonstrated high degree of sensitivity, precision, and accuracy. • High relevance for the clinical diagnosis of pheochromocytomas and paragangliomas.
Published in Analytica Chimica Acta
• Microfluidic chip and LAMP were firstly integrated for high-throughput and multitarget detection of PEDV, PDCoV and SADS-CoV. • The microfluidic-RT-LAMP chip system established greatly facilitated the rapid diagnosis of the PEDV, PDCoV and SADS-CoV. • The microfluidic chip device provides excellent prospects in swine enteric coronaviruses surveil...
