He, Zhengchang Shen, Shaoxian Yi, Yuyao Ren, Lingli Tao, Huan Wang, Fujue Jia, Yongqian
Published in
American journal of translational research
Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell non-Hodgkin's lymphoma. Invasive DLBCL cells are likely to metastasize into extranodal tissue (e.g., the central nervous system) that is difficult for chemotherapy drugs to penetrate, seriously affecting patient prognosis. The mechanism of DLBCL invasion remains unclear. This study inves...
Sun, Changqi Chang, Kenny Fleming, Braden C Owens, Brett D Beveridge, Jillian E Gage, Andrew Talley-Bruns, Rachel C McAllister, Scott Costa, Meggin Q Pinette, Megan P
...
Published in
American journal of translational research
Animal models are needed to reliably separate the effects of mechanical joint instability and inflammation on posttraumatic osteoarthritis (PTOA) pathogenesis. We hypothesized that our modified intra-articular drilling (mIAD) procedure induces cartilage damage and synovial changes through increased inflammation without causing changes in gait. Twen...
Liu, Zhihui Li, Mingyang Sun, Yu Wang, Weiguo Wang, Zhisong Presicce, Giorgio Antonio An, Liyou Du, Fuliang
Published in
American journal of translational research
We examined the epigenetic dynamics of histone H4K20 trimethylation (H4K20me3), a repressive signature in heterochromatin, during goat oocyte meiosis and the reprogramming of somatic cell nuclear transfer (NT) embryos through the first three cell divisions. Following NT, oocytes were treated with parthenogenetic activation (PA), by 5 µM calcium ion...
Zhu, Jingjing Tian, Hongjun Wang, Haibo Yu, Haiping Liu, Chuanxin Wang, Lina Li, Qianchen Fang, Tao Jia, Feng Li, Yachen
...
Published in
American journal of translational research
Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of COVID-19 vaccines in MPD patients have not been fully evaluated. This study aimed to investigate adverse event...
Luan, Weihong Yuan, Haozhan Hou, Wei Li, Jing Liu, Liping
Published in
American journal of translational research
To explore the effect of nimotuzumab combined with Taxol + Cisplatin (TP) regimen induction chemotherapy and sequential concurrent chemoradiotherapy on the improvement of curative effect and prognosis of patients with locally advanced nasopharyngeal carcinoma. A retrospective analysis was performed on 91 patients with locally advanced nasopharyngea...
Qi, Ke-Yan Shen, Ming Yang, Kai Yan, You-Sheng Wu, Jue Wang, Yi-Peng Yin, Cheng-Hong
Published in
American journal of translational research
Turnpenny-Fry syndrome (TPFS) has recently been defined as an uncommon monogenic disease and is characterized by global developmental delay (GDD), intellectualdisability (ID), facial dysmorphology, and skeletal abnormality. PCGF2 is the only known causative gene for TPFS, which is a component of polycomb repressive complex 1 (PRC1). PRC1 is a multi...
Xu, Yibo Wang, Zhimeng Wang, Yakang Huang, Qiang Ren, Cheng Sun, Liang Wang, Qian Li, Ming Liu, Hongliang Li, Zhong
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Published in
American journal of translational research
Mesenchymal stem cells derived from human tissues have been widely used for tissue regeneration because of their strong self-renewal capacity and multi-potential properties. Autophagy plays a vital role in maintaining bone homeostasis. However, the mechanism underlying this role for autophagy in the osteogenic differentiation of mesenchymal stem ce...
Li, Cuicui Gao, Bingbing Lin, Hepu Li, Yunjun Xiu, Bo Dai, Yiwu
Published in
American journal of translational research
The purpose of this study was to investigate the clinical value of microsurgery in the treatment of congenital neural tube defect (CNTD) in newborns. Eighty-five CNTD newborns withlipomyelomeningocele admitted to our hospital from March 2016 to December 2018 were retrospectively selected as study subjects. They were divided into a study group (SG, ...
Gao, Beibei Zhu, Darong Xie, Jianchang Wu, Bokai Xu, Peng Liu, Jia Tong, Xiaoshan Chen, Rongliang Zhu, Lijun Zhou, Liang
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Published in
American journal of translational research
Accurate and rapid assessment of the coronary microcirculation has become an important medical challenge. However, reliable and non-invasive quantitative methods to diagnose coronary microvascular disease (CMVD), select treatments for coronary artery disease (CAD), and therefore improve coronary microcirculation are lacking. Current detection metho...
Jin, Jiahui He, Jingjing Yan, Xinyu Zhao, Yaru Zhang, Haojie Zhuang, Kai Wen, Yating Gao, Junzhen
Published in
American journal of translational research
Screening for epidermal growth factor receptor (EGFR) mutations is the key to select suitable patients with non-small cell lung cancer (NSCLC) for EGFR-TKI therapy in clinical practice. Nevertheless, tumor tissue that needed for mutation analysis is frequently unavailable, especially for patients with recurrence after operation. Therefore, detectio...
