Croft, Amanda J Kelly, Conagh Chen, Dongqing Haw, Tatt Jhong Balachandran, Lohis Murtha, Lucy A Boyle, Andrew J Sverdlov, Aaron L Ngo, Doan T M
Published in
American journal of physiology. Heart and circulatory physiology
Sex-based differences in the development of obesity-induced cardiometabolic dysfunction are well documented, however, the specific mechanisms are not completely understood. Obesity has been linked to dysregulation of the epitranscriptome, but the role of N6-methyladenosine (m6A) RNA methylation has not been investigated in relation to the sex diffe...
Ferreira, Ana Filipa Azevedo, Maria João Morais, Juliana Almeida-Coelho, João Leite-Moreira, André M Lourenço, André P Saraiva, Francisca Diaz, Sílvia O Amador, Ana Filipa Sousa, Carla
...
Published in
American journal of physiology. Heart and circulatory physiology
Pressure overload-induced hypertrophy compromises cardiac stretch-induced compliance (SIC) after acute volume overload (AVO). We hypothesized that SIC could be enhanced by physiological hypertrophy induced by pregnancy's chronic volume overload. This study evaluated SIC-cardiac adaptation in pregnant women with or without cardiovascular risk (CVR) ...
Neff, Lily S Biggs, Rachel M Zhang, Yuhua Van Laer, An O Baicu, Catalin F Subramanian, Suganya Berto, Stefano DeLeon-Pennell, Kristine Zile, Michael R Bradshaw, Amy D
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Published in
American journal of physiology. Heart and circulatory physiology
Sustained hemodynamic pressure overload (PO) produced by murine transverse aortic constriction (TAC) causes myocardial fibrosis; removal of TAC (unTAC) returns left ventricle (LV) hemodynamic load to normal and results in significant, but incomplete regression of myocardial fibrosis. However, the cellular mechanisms that result in these outcomes ha...
Suriani, Irene Bouwman, R Arthur Mischi, Massimo Lau, Kevin D
Published in
American journal of physiology. Heart and circulatory physiology
Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond chronological age, making the clinical assessment of cardiovascular aging an important prompt for preve...
Lindsey, Merry L Usselman, Charlotte W Ripplinger, Crystal M Carter, Jason R DeLeon-Pennell, Kristine Y
Published in
American journal of physiology. Heart and circulatory physiology
There have been ongoing efforts by federal agencies and scientific communities since the early 1990s to incorporate sex and/or gender in all aspects of cardiovascular research. Scientific journals provide a critical function as change agents to influence transformation by encouraging submissions for topic areas, and by setting standards and expecta...
Damacena de Angelis, Celio Meddeb, Mariam Chen, Nelson Fisher, Steven A
Published in
American journal of physiology. Heart and circulatory physiology
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more broadly. The myosin phosphatase (MP) enzyme is a critical hub upon which signals converge to regulate vessel tone. Alternative exon 24 of myosin phosphatase regulatory subunit (Mypt1 E24) is an ideal target as toggling between...
Tahsin, Chowdhury Tasnova Anselmo, Miguel Lee, Emma Stokes, William Fonkoue, Ida T Vanden Noven, Marnie L Carter, Jason R Keller-Ross, Manda L
Published in
American journal of physiology. Heart and circulatory physiology
Sleep disturbance, one of the most common menopausal symptoms, contributes to autonomic dysfunction and is linked to hypertension and cardiovascular risk. Longitudinal studies suggest that hyperreactivity of blood pressure (BP) to a stressor can predict the future development of hypertension. It remains unknown if postmenopausal females who experie...
Reeve, Emily H Barnes, Jill N Moir, M Erin Walker, Ashley E
Published in
American journal of physiology. Heart and circulatory physiology
With advancing age, the cerebral vasculature becomes dysfunctional, and this dysfunction is associated with cognitive decline. However, the initiating cause of these age-related cerebrovascular impairments remains incompletely understood. A characteristic feature of the aging vasculature is the increase in stiffness of the large elastic arteries. T...
Troy, Aaron M Normukhamedova, Diyora Grothe, Daniela Momen, Abdul Zhou, Yu-Qing McFadden, Meghan Hussain, Mansoor Billia, Filio Cheng, Hai-Ling Margaret
Published in
American journal of physiology. Heart and circulatory physiology
Heart failure with preserved ejection fraction (HFpEF) afflicts over half of all patients with heart failure and is a debilitating and fatal syndrome affecting postmenopausal women more than any other demographic. This bias toward older females calls into question the significance of menopause in the development of HFpEF, but this question has not ...
Stege, Nienke M Oliveira Nunes Teixeira, Vivian Zijlstra, Sietske N Feringa, Anna M de Boer, Rudolf A Silljé, Herman H W
Published in
American journal of physiology. Heart and circulatory physiology
The phospholamban (PLN) pathogenic gene variant p.Arg14del causes cardiomyopathy, which is characterized by perinuclear PLN protein clustering and can lead to severe heart failure (HF). Elevated expression of dwarf open reading frame (DWORF), a protein counteracting the function of PLN in the sarcoplasmic reticulum (SR), can delay disease progressi...
