Modi, Mitul B Kiszluk, Alexandra Chai, Jiani N Edema, Ukuemi Ma, Maxwell Y Sica, R Alejandro Wang, Yanhua Shi, Yang
Published in
American journal of clinical pathology
Adult T-cell leukemia/lymphoma (ATLL) is a rare aggressive T-cell leukemia/lymphoma associated with human T lymphotropic virus type 1 infection. The patients might present with skin rash before, at, or after the diagnosis. The dermatopathologic finding might be diagnostically very challenging. We retrospectively identified 110 patients with ATLL at...
Chang, Denis Kim, Charlotte F Horton, Maxwell Lee, Dale Pacheco, M Cristina Silvester, Jocelyn A Goldsmith, Jeffrey D
Published in
American journal of clinical pathology
To assess if the distribution of villous intraepithelial lymphocytes (IELs) in a pediatric cohort with Marsh I histopathology is specific to celiac disease (CeD). Multicenter, retrospective case-control study between January 2001 and December 2019 in children (
Hoerres, Derek Dai, Qunsheng Elmore, Sandra Sheth, Siddharth Gupta, Gaorav P Kumar, Sunil Gulley, Margaret L
Published in
American journal of clinical pathology
Accurate monitoring of disease burden depends on accurate disease marker quantification. Although next-generation sequencing (NGS) is a promising technology for noninvasive monitoring, plasma cell-free DNA levels are often reported in misleading units that are confounded by non-disease-related factors. We proposed a novel strategy for calibrating N...
Fukuto, Hana S Nelepcu, Iulian I Necula, Steliana Galli, Nora E Viboud, Gloria I
Published in
American journal of clinical pathology
The implementation of nucleic acid testing in laboratory medicine has revolutionized clinical diagnosis. Unfortunately, incorporation of these technologies in less developed countries remains a challenge. Despite Romania's recent economic growth, the country is in dire need of medical and laboratory staff trained in modern technologies. The aim of ...
Hiramatsu, Kaho Matsuda, Chiaki Masago, Katsuhiro Toriyama, Kazuhiro Sasaki, Eiichi Fujita, Yasuko Haneda, Masataka Ebi, Hiromichi Shibata, Noriko Hosoda, Waki
...
Published in
American journal of clinical pathology
DNA integrity number (DIN) is a metric for assessing DNA degradation, calculated based on electrophoresis using the Agilent TapeStation System. The utility of DIN as a diagnostic indicator of sufficient DNA quality in clinical next-generation sequencing (NGS) has not been well described. We evaluated the DINs of 166 tumor formalin-fixed, paraffin-e...
Fels Elliott, Daffolyn Rachael Konopka, Kristine E Hrycaj, Steven M Lagisetty, Kiran H Myers, Jeffrey L Farver, Carol F Huang, Tao
Published in
American journal of clinical pathology
To report histologic features of unsuspected diffuse pleural mesothelioma (DPM) in surgical specimens for pneumothorax and demonstrate how ancillary markers support a diagnosis of malignancy in this context. We explored whether pneumothorax may be a clinical manifestation of mesothelioma in situ (MIS). A single-institution database search identifie...
Bahmad, Hisham F Oh, Kei Shing Delgado, Ruben Azimi, Roshanak Olivares, Esperanza Poppiti, Robert Howard, Lydia Alghamdi, Sarah
Published in
American journal of clinical pathology
To improve documentation of blood product administration by assessing the completion status of blood transfusions. In this way, we can ensure compliance with the Association for the Advancement of Blood & Biotherapies standards and facilitate investigation of potential blood transfusion reactions. This before-and-after study includes the implementa...
Benirschke, Robert C Lee, Hong Kee
Published in
American journal of clinical pathology
The hook effect is a common preanalytical error that results in falsely decreased analyte concentrations in immunoassays. We present here an example in a semiquantitative SARS-CoV-2 antispike total antibody assay and report the incidence of this error at our institution. All specimens with initial results within the reportable range of the assay we...
Tekin, Burak Gilani, Sarwat I Dasari, Surendra Theis, Jason D Rech, Karen L Dao, Linda N Cubilla, Antonio L Herrera Hernandez, Loren P Jimenez, Rafael E Cheville, John C
...
Published in
American journal of clinical pathology
There is a paucity of data on penile amyloidosis. We aimed to assess the frequency of different amyloid types in surgical specimens from the penis involved by amyloidosis and correlate relevant clinicopathologic parameters with proteomic findings. Since 2008, our reference laboratory has performed liquid chromatography/tandem mass spectrometry (LC-...
Batuello, Christopher Mason, Emily F
Published in
American journal of clinical pathology
Epstein-Barr virus-positive large B-cell lymphoma (EBV+ LBCL) is a heterogeneous group of diseases that may resemble classic Hodgkin lymphoma (CHL) both morphologically and immunophenotypically. However, these diseases are treated with different therapies and carry distinct prognoses. We examined CD200 expression by immunohistochemistry in EBV+ LBC...
