Boukhar, Sarag A Gosse, Matthew D Bellizzi, Andrew M Rajan K D, Anand
Published in
American journal of clinical pathology
The Ki-67 proliferation index is integral to gastroenteropancreatic neuroendocrine tumor (GEP-NET) assessment. Automated Ki-67 measurement would aid clinical workflows, but adoption has lagged owing to concerns of nonequivalency. We sought to address this concern by comparing 2 digital image analysis (DIA) platforms to manual counting with same-cas...
Hauser, Ronald G Esserman, Denise Beste, Lauren A Ong, Shawn Y Colomb, Denis G Bhargava, Ankur Wadia, Roxanne Rose, Michal G
Published in
American journal of clinical pathology
Chronic myelogenous leukemia (CML) is a clonal stem cell disorder accounting for 15% of adult leukemias. We aimed to determine if machine learning models could predict CML using blood cell counts prior to diagnosis. We identified patients with a diagnostic test for CML (BCR-ABL1) and at least 6 consecutive prior years of differential blood cell cou...
Ayala-Lopez, Nadia Peaper, David R Harb, Roa
Published in
American journal of clinical pathology
Despite extensive research on procalcitonin (PCT)-guided therapy in lower respiratory tract infections, the association between PCT and bacterial pneumonia remains unclear. We evaluated retrospectively the performance of PCT in patients presenting with lower respiratory tract infection symptoms and grouped by seven diagnoses. All patients had micro...
Harb, Roa Kachimanga, Chiyembekezo Bangura, Musa Kanawa, Sahr Stratton, Charles W Milner, Dan A Eichbaum, Quentin
Published in
American journal of clinical pathology
We developed and participated in a 1-week laboratory medicine training presented from June 3, 2019, to June 7, 2019. The training was a combination of daily morning lectures and case presentations as well as afternoon practical sessions in the clinical laboratory. The content was selected over months by local organizers and the visiting faculty and...
Yi, Xin Chan, Clarence W Yeo, Kiang-Teck J
Published in
American journal of clinical pathology
Rozza-de-Menezes, Rafaela E Almeida, Lilian M Andrade-Losso, Raquel M de Souza Vieira, Gustavo Siqueira, Orlando H K Brum, Carolina I Riccardi, Vincent M Cunha, Karin S
Published in
American journal of clinical pathology
To evaluate the expression of progesterone receptor (PR), estrogen receptor (ER), and G protein-coupled estrogen receptor 1 (GPER-1) in cutaneous neurofibromas (cNFs) and their correlation with demographic, clinical, and laboratory data of individuals with neurofibromatosis 1 (NF1). The association of PROGINS polymorphism and PR expression in cNFs,...
Chatzopoulos, Kyriakos Johnson, Tucker F Boland, Jennifer M
Published in
American journal of clinical pathology
To investigate the clinicopathologic and radiologic features of pulmonary hamartomas (PHs) with uncommon clinical presentation. A retrospective clinicopathologic and radiologic review was performed for patients diagnosed (1999-2019) with multiple hamartomas, lesions arising adjacent to a coexisting pulmonary malignancy, and tumors with predominantl...
Karpathiou, Georgia Casteillo, Francois Dridi, Maroa Peoc'h, Michel
Published in
American journal of clinical pathology
Peritoneal mesothelial cysts have been reported under various terms, including benign cystic mesothelioma, usually in the form of case reports/series, whereas extraperitoneal cases are rarely reported. Our objective was to report the detailed characteristics of cystic lesions of the serosal cavities. We retrospectively examined the clinicopathologi...
Crotty, Rory Hu, Krista Stevenson, Kristen Pontius, Maggie Y Sohani, Aliyah R Ryan, Russell J H Rueckert, Erroll Brauer, Heather A Hudson, Briana Berlin, Aaron M
...
Published in
American journal of clinical pathology
Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with a heterogenous genetic landscape that can require multiple assays to characterize. We reviewed a 1-step RNA-based assay to determine cell of origin (COO), detect translocations, and identify mutations and to assess the role of the assay in diagnosis. Using a single cus...
Wong, Mary Waters, Kevin M Guindi, Maha Larson, Brent K
Published in
American journal of clinical pathology
Previous studies described "clear cell" hepatocellular carcinoma (HCC), although definitions have varied. New clear cell subtypes of HCC have been proposed, including chromophobe (C-HCC), steatohepatitic (SH-HCC), and steatotic (S-HCC), and this study assessed the utility and clinical-pathologic profile of these subtypes. Current histologic definit...
