Abi-Raad, Rita Lavik, John-Paul Barbieri, Andrea L Zhang, Xuchen Adeniran, Adebowale J Cai, Guoping
Published in
American journal of clinical pathology
This study aimed to determine whether Ki-67 index evaluated on cytologic material could reliably grade pancreatic neuroendocrine tumors (PanNETs). Cases with adequate cell block and available surgical specimens were included. Ki-67 index was calculated using "eyeballing," "hot spot," and "complete" counting methods. The overall concordance rates be...
Bulte, Joris P Halilovic, Altuna Burgers, Lambert J M Diepenbroek, Coos J M de la Roij, Robin A K Mann, Ritse M van der Leest, Marloes van Cleef, Patricia H J Strobbe, Luc J A de Wilt, Johannes H W
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Published in
American journal of clinical pathology
Vacuum-assisted biopsy (VAB) of the breast seems unsuitable for rapid processing due to large size. We tested microwave-based acceleration. As a proof-of-principle study, 9-gauge VAB specimens were taken from eight mastectomy specimens. Forty-two biopsy specimens were processed. Quality of H&E was evaluated in 84 slides, and estrogen receptor (ER),...
Lapić, Ivana Padoan, Andrea Bozzato, Dania Plebani, Mario
Published in
American journal of clinical pathology
To assess the diagnostic accuracy of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in acute inflammation. PubMed and Scopus were searched and eligible articles were screened for methodologic quality using the Quality Assessment of the Diagnostic Accuracy Studies-Revised. Meta-analysis with calculation of pooled sensitivity (Se),...
Xiao, Guang-Qian Golestani, Reza Pham, Huy Sherrod, Andy E
Published in
American journal of clinical pathology
High-grade prostatic intraepithelial neoplasia (HPIN) and atypical cribriform lesion of the prostate are considered the precursors or associators of invasive prostate cancer (iPCa). Given loss of basal cells being the hallmark of iPCa, we hypothesized that a subset of these atypical intraepithelial lesions (AILs) with sparse basal cells can be clas...
Laga, Alvaro C Schaefer, Inga Marie Sholl, Lynette M French, Christopher A Hanna, John
Published in
American journal of clinical pathology
Diagnosis of metastatic basal cell carcinoma (BCC) remains challenging, in part due to its rarity. With the advent of molecularly targeted therapies, recognition of this entity is more important than ever. We identified 11 cases of metastatic BCC over a 13-year period. We analyzed these tumors in conjunction with their respective primary tumors by ...
Norgan, Andrew P Sloan, Lynne M Pritt, Bobbi S
Published in
American journal of clinical pathology
Pathogenic free-living amebae (FLAs) cause skin, ocular, and central nervous system (CNS) infections with significant morbidity and mortality. Diagnosis of FLA infections by pathologic examination of tissue sections can be aided using molecular assays. This study investigated the performance characteristics of a multiplex real-time polymerase chain...
Gumma, Vidyanidhi Bennett, Davara Lee Nguyen Thi Phong, Lan Duong Ngoc, Cuong Bond, Kyle B Nguyen Thi Hoang, Yen Erni, Donatelle Nguyen Van, Nhung Nguyen Van, Hung Albert, Heidi
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Published in
American journal of clinical pathology
Early diagnosis of tuberculosis (TB) and multidrug-resistant TB (MDR-TB) is a priority for Viet Nam's National TB Control Programme. In many laboratories, quality systems are weak; few have attained accreditation. We implemented a structured training and mentoring program for TB laboratories and measured impact on quality. Six TB culture laboratori...
Rusanganwa, Vincent Gahutu, Jean Bosco Evander, Magnus Hurtig, Anna-Karin
Published in
American journal of clinical pathology
To explore challenges explaining the decrease in quality performance and suggest strategies to improve and sustain laboratory quality services. Twenty key informants' interviews from laboratory personnel were conducted in five laboratories. Four had previously shown a decrease in quality performance. Interviews were transcribed verbatim and analyze...
Strosberg, Carolina Ferlito, Alfio Triantafyllou, Asterios Gnepp, Douglas R Bishop, Justin A Hellquist, Henrik Strojan, Primoz Willems, Stefan M Stenman, Göran Rinaldo, Alessandra
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Published in
American journal of clinical pathology
Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities. A review of the literature was ...
Schumacher, Jonathan A Holgard, Victoria D Sial, Faryal Pearson, Lauren N Patel, Jay L Karner, Kristin H
Published in
American journal of clinical pathology
Many commonly used FLT3 mutational assay protocols require a tedious blast enrichment step. We investigated whether elimination of this step would still give equivalent results and compared the accuracy of variant allele fraction (VAF) between polymerase chain reaction/capillary electrophoresis (PCR/CE) vs next-generation sequencing (NGS) methods. ...
