AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.
Published in American Journal of Physiology-Cell Physiology
Editorial
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regula...
Published in American Journal of Physiology-Cell Physiology
A defect in protein turnover underlies multiple forms of cell atrophy. Since S6 kinase (S6K)-deficient cells are small and display a blunted response to nutrient and growth factor availability, we have hypothesized that mutant cell atrophy may be triggered by a change in global protein synthesis. By using mouse genetics and pharmacological inhibito...
Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation.
Published in American Journal of Physiology-Cell Physiology
A renewed interest in tricarboxylic acid cycle enzymopathies has resulted from the report that, in addition to devastating encephalopathies, these can result in various types of tumors in human. We first review the major features of the cycle that may underlie this surprising variety of clinical features. After discussing the rare cases of encephal...
Ultraviolet A radiation transiently disrupts gap junctional communication in human keratinocytes.
Published in American Journal of Physiology-Cell Physiology
Ultraviolet A (UVA) (320-400 nm) radiation is known to cause cutaneous aging and skin cancer. We studied the effect of UVA (365 nm) radiation on the human epidermis by focusing on keratinocyte gap junction-mediated intercellular communication (GJIC). We observed a dose-dependent 10-fold decrease in GJIC induced by UVA in normal human keratinocytes....
