Published in American journal of obstetrics and gynecology
Maternally administered MSCs appear to modulate maternal and fetal immune response to intrauterine inflammation in the model and decrease preterm birth, perinatal brain injury, and motor deficits in offspring mice.
Published in American Journal of Obstetrics and Gynecology
PRLR(I146L) is the first identified gain-of-function variant of the prolactin receptor (PRLR) that was proposed to be associated with benign breast tumorigenesis. Structural investigations suggested this hydrophobic core position in the extracellular D2 domain to be linked to receptor dimerization. Here, we used a mutational approach to address how...
Published in American journal of obstetrics and gynecology
Although most lifestyle factors and psychologic distress were not predictive of adverse pregnancy outcomes, the risk for miscarriage was significantly increased among survivors exposed to >2.5 Gy uterine radiation who had a history of smoking.
Published in American journal of obstetrics and gynecology
Antenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events among preterm infants who were and were not exposed to anteMg....
Published in American journal of obstetrics and gynecology
Our findings indicate that medium conditioned by primary human trophoblasts attenuates viral infection in nontrophoblastic cells. Our data point to a trophoblast-specific antiviral effect that may be exploited therapeutically.
Published in American journal of obstetrics and gynecology
Our data demonstrate an adverse association of sulindac with NEC. These findings deserve further investigation and using sulindac as a tocolytic agent requires caution.
Published in American journal of obstetrics and gynecology
Targeted and shotgun serum proteomics analyses associated 1 protein, serpin B7, with early SPTB. Our results require validation in other cohorts and analysis of the possible mechanistic role of serpin B7 in parturition.
Published in American journal of obstetrics and gynecology
Sham surgical incisions effectively mask TVT randomization. These findings may help to inform future surgical trial designs.
Published in American Journal of Obstetrics and Gynecology
ObjectiveThe objective of this study was to validate the clinical performance of massively parallel genomic sequencing (MPS) of cell-free DNA contained in specimens from pregnant women at high risk for fetal aneuploidy to test fetuses for trisomies 21, 18, 13, fetal sex and the common sex chromosome aneuploidies (45, X; 47, XXX; 47, XXY; 47, XYY). ...
Published in American Journal of Obstetrics and Gynecology
ObjectiveTo assess maternal prenatal use of analgesics and risk of cardiovascular malformations (CVM) in the offspring. Study DesignData from the Baltimore-Washington Infant Study, a population based case-control investigation of CVM, were used to examine selected isolated CVM diagnoses and maternal analgesic use during the periconceptional period ...
