Vylet’al, Petr Kidd, Kendrah Ainsworth, Hannah C. Springer, Drahomíra Vrbacká, Alena Přistoupilová, Anna Hughey, Rebecca P. Alper, Seth L. Lennon, Niall Harrison, Steven
...
Published in
American Journal of Nephrology
Introduction: Patients with ADTKD-MUC1 have one allele producing normal mucin-1 (MUC1) and one allele producing mutant MUC1, which remains intracellular. We hypothesized that ADTKD-MUC1 patients, who have only 1 secretory-competent wild-type MUC1 allele, should exhibit decreased plasma mucin-1 (MUC1) levels. To test this hypothesis, we repurposed t...
Shigematsu, Takashi Une, Yotaro Ikejiri, Kazuaki Kanda, Hironori Fukagawa, Masafumi Akizawa, Tadao
Published in
American Journal of Nephrology
Introduction Phosphate binders are used to treat hyperphosphatemia. Some patients have inappropriately controlled serum phosphorus levels, which may occur for many reasons, including a high pill burden and adverse events (AEs). Tenapanor selectively inhibits the passive paracellular transfer of phosphate in the gastrointestinal tract, thereby reduc...
Banerjee, Tanushree Carrero, Juan Jesus McCulloch, Charles Burrows, Nilka Rios Siegel, Karen R. Morgenstern, Hal Saran, Rajiv Powe, Neil R.
Published in
American Journal of Nephrology
Background: The association between fruit and vegetable (FV) intake and the risk of end-stage kidney disease (ESKD) has not been examined in the general population and fully explored in chronic kidney disease (CKD). We prospectively evaluated this relationship in US representative sample of adults and evaluated consistency by the presence or absenc...
Hering, Dagmara Hubbard, Brad S. Weber, Michael A. Heuser, Richard R.
Published in
American Journal of Nephrology
Introduction: The blood pressure (BP) response to arterial renal denervation (RDN) is variable. Methods: This study examined the effectiveness of renal pelvic denervation (RPD) on BP, heart rate (HR), norepinephrine (NE), and histopathology in 42 swine. NE levels were measured immediately, 7, 14, 30, and 90 days after RPD. Intra-arterial BP and HR ...
Sheshadri, Anoop Kittiskulnam, Piyawan Delgado, Cynthia Sudore, Rebecca L. Lai, Jennifer C. Johansen, Kirsten L.
Published in
American Journal of Nephrology
Introduction: A randomized, controlled trial of a pedometer-based walking intervention with weekly activity goals led to increased walking among dialysis patients. We examined whether impairment per cognitive function screening is associated with adherence and performance in the intervention. Methods: Thirty dialysis patients were randomly assigned...
Vodošek Hojs, Nina Ekart, Robert Bevc, Sebastjan Piko, Nejc Hojs, Radovan
Published in
American Journal of Nephrology
Introduction: Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients is important and could lead to a different approach and better treatment. The CHA2DS2-VASc score was originally used to predict cerebral infarction in patients with atrial fibrillation (AF), but it is also a usef...
Vogt, Liffert Gansevoort, Ron T.
Published in
American Journal of Nephrology
Ozcan, Cevher
Published in
American Journal of Nephrology
Shen, Wen Alshehri, Mohammed Desale, Sameer Wilcox, Christopher
Published in
American Journal of Nephrology
Introduction: Proteinuric kidney diseases share an aggressive clinical course of developing end-stage renal disease. However, the treatment is limited. Amiloride, an epithelial sodium channel (ENaC) inhibitor, was reported to reduce proteinuria in animal studies and case reports independent of ENaC inhibition. We hypothesized that amiloride not tri...
Subramanian, Nivetha Han, Jialin Leeper, Nicholas J. Ross, Elsie G. Montez-Rath, Maria E. Chang, Tara I.
Published in
American Journal of Nephrology
Introduction: Patients with chronic kidney disease (CKD) and peripheral artery disease (PAD) are more likely to undergo lower extremity amputation than patients with preserved kidney function. We sought to determine whether patients with CKD were less likely to receive pre-amputation care in the 1-year prior to lower extremity amputation compared t...
