Suzuki, Yuta Kaneko, Hidehiro Okada, Akira Fujiu, Katsuhito Michihata, Nobuaki Jo, Taisuke Takeda, Norifumi Morita, Hiroyuki Kamiya, Kentaro Matsunaga, Atsuhiko
...
Published in
American Journal of Nephrology
Introduction: We examined the association of proteinuria with the risk for heart failure (HF) and other cardiovascular disease (CVD) events in patients with prior history of breast, colorectal, or stomach cancer using a nationwide population-based database. Methods: We conducted this retrospective observation study using the JMDC Claims Database an...
Faitatzidou, Danai Dipla, Konstantina Theodorakopoulou, Marieta P. Koutlas, Aggelos Karagiannidis, Artemios Alexandrou, Maria-Eleni Tsouchnikas, Ioannis Giamalis, Panagiotis Dimitriadis, Chrysostomos Zafeiridis, Andreas
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Published in
American Journal of Nephrology
Introduction: Cardiac arrhythmias are the most common cause of death in hemodialysis. Autonomic dysfunction plays a central role in this arrhythmogenic background. Previous studies on hemodialysis-related changes in heart rate variability (HRV) give contradictory results. This study investigated HRV indices both at rest and in response to physical ...
Li, Xiejia Lindholm, Bengt
Published in
American Journal of Nephrology
Background: As one of the main complications of chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) in CKD patients is high. CVD risk is markedly increased even at early stages of CKD, and CVD deaths account for half of all known causes of mortality in end-stage renal disease patients. The alarming rate of CVD in CKD patient...
Mathur, Vandana S. Wesson, Donald E. Li, Elizabeth Tangri, Navdeep
Published in
American Journal of Nephrology
Introduction: The percentage of patients initiating dialysis at an estimated glomerular filtration rate (eGFR) ≤9 mL/min/1.73 m2 decreased between 2000 and 2018 in the USA. Clinical practice guidelines recommend basing the decision to initiate dialysis primarily on uremic signs and symptoms rather than on a particular level of kidney function. Howe...
Wesson, Donald E. Mathur, Vandana Tangri, Navdeep
Published in
American Journal of Nephrology
Background: Frailty is common in patients with chronic kidney disease (CKD), as is its physical component, phenotypic frailty, and each contributes to CKD-related disability and are associated with increased mortality. Chronic kidney disease has been described as a model of premature aging and its phenotypic frailty shares features with that which ...
Agarwal, Rajiv Anand, Sanjeev Eckardt, Kai-Uwe Luo, Wenli Parfrey, Patrick S. Sarnak, Mark J. Solinsky, Christine M. Vargo, Dennis L. Winkelmayer, Wolfgang C. Chertow, Glenn M.
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Published in
American Journal of Nephrology
Introduction: Anemia frequently occurs in chronic kidney disease (CKD), is associated with poor quality of life and cardiovascular outcomes, and its treatment represents a considerable economic burden to the healthcare system. Although effective, the current standard of care for the treatment of anemia in chronic kidney disease patients with erythr...
Nester, Carla Appel, Gerald B. Bomback, Andrew S. Bouman, Koenraad Peter Cook, H. Terence Daina, Erica Dixon, Bradley P. Rice, Kara Najafian, Nader Hui, James
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Published in
American Journal of Nephrology
Introduction: C3 glomerulopathy (C3G) is an ultrarare, chronic and progressive nephropathy mediated by dysregulation of the alternative pathway of complement (AP), with poor prognosis and limited treatment options. Targeted inhibition of proximal AP through factor D (FD) blockade represents a rational treatment approach. We present two phase 2 proo...
Gutbrod, Joseph Keys McKay, Charles Clayton Coe, Lillian Bergsland, Kristin Coe, Fredric Worcester, Elaine Prochaska, Megan
Published in
American Journal of Nephrology
Introduction: Lowering kidney stone risk and urine calcium oxalate supersaturation is a primary clinical focus for kidney stone prevention and can be achieved with multiple strategies. Common strategies include advice to increase fluid intake, restrict dietary sodium, or prescribing a thiazide-type diuretic. We investigated how physicians make thes...
Podos, Steven D. Trachtman, Howard Appel, Gerald B. Bomback, Andrew S. Dixon, Bradley P. Wetzels, Jack F.M. Cook, H. Terence Parikh, Samir V. Pickering, Matthew C. Tumlin, James
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Published in
American Journal of Nephrology
Introduction: C3 glomerulopathy (C3G) is a rare, progressive kidney disease resulting from dysregulation of the alternative pathway (AP) of complement. Biomarkers at baseline were investigated in patients with C3G who participated in two phase 2 studies with the factor D (FD) inhibitor, danicopan. Methods: Patients with biopsy-confirmed C3G, protei...
Tangri, Navdeep Mathur, Vandana Reaven, Nancy Funk, Susan E. Wesson, Donald E.
Published in
American Journal of Nephrology
Introduction: Metabolic acidosis is associated with chronic kidney disease (CKD) progression and mortality, but the association of race/ethnicity with incident metabolic acidosis and/or its adverse outcomes in patients with CKD is unknown. Methods: We used deidentified medical records data (2007–2019) to generate a cohort of 136,067 patients with n...
