Wang, Luwen Li, Xun Chen, Hui Yan, Shaonan Li, Dong Li, Yan Gong, Zuojiong
Published in
American Journal of Nephrology
Background Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data o...
Ferrey, Antoney J. Choi, Grace Hanna, Ramy M. Chang, Yongen Tantisattamo, Ekamol Ivaturi, Kaushik Park, Elisa Nguyen, Lawrence Wang, Brian Tonthat, Sam
...
Published in
American Journal of Nephrology
Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral disease with an alarming case fatality rate up to 5%. The risk factors for severe presentations are concentrated in patients with chronic kidney disease, particularly patients with end-stage renal disease (ESRD) who are dialysis dependent. We report the first ...
Weir, Matthew R. McCullough, Peter A. Buse, John B. Anderson, John
Published in
American Journal of Nephrology
Background: Chronic kidney disease (CKD) risk is elevated in patients with type 2 diabetes mellitus (T2DM). Disease management in these patients has been generally focused on glycemic control and controlling other renal and cardiac risk factors as, historically, few protective therapies have been available. The Canagliflozin and Renal Events in Dia...
Morris, Adam D. Elsayed, Mohamed E. Ponnusamy, Arvind Rowbottom, Anthony Martin, Francis Geetha, Duvuru Dhaygude, Ajay P.
Published in
American Journal of Nephrology
Background: The benefits of treating anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) in advancing age remains unclear with most published studies defining elderly as ≥65 years. This study aims to determine outcomes of induction immunosuppression in patients aged ≥75 years. Methods: A cohort of patients aged ≥75 years with a dia...
Li, Philip Kam-Tao Garcia-Garcia, Guillermo Lui, Siu-Fai Andreoli, Sharon Fung, Winston Wing-Shing Hradsky, Anne Kumaraswami, Latha Liakopoulos, Vassilios Rakhimova, Ziyoda Saadi, Gamal
...
Published in
American Journal of Nephrology
The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income coun...
Packer, Milton
Published in
American Journal of Nephrology
The 2 most common causes of chronic kidney disease worldwide (type 2 diabetes and obesity) are states of nutrient excess, suggesting that fuel overabundance leads to deleterious effects on the structure and function of the kidneys. Three pathophysiological pathways may potentially explain this linkage. First, both obesity and type 2 diabetes are ch...
Liu, Zi-ning Cui, Zhao He, Ying-dong Zhang, Yi-miao Wang, Fang Wang, Xin Meng, Li-qiang Cheng, Xu-yang Liu, Gang Zhao, Ming-hui
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Published in
American Journal of Nephrology
Background: Primary membranous nephropathy (pMN) is less common in women of child-bearing age. The kidney risk factors to adverse maternal-fetal outcomes and the effects of pregnancy on pMN process need to be investigated. Methods: We retrospectively screened all the patients with biopsy-proven pMN from 2008 to 2018. Any cases of pregnancy that occ...
Allegretti, Andrew S. Endres, Paul Parris, Tyler Zhao, Sophia May, Megan Sylvia-Reardon, Mary Bezreh, Nicole Culbert-Costley, Roberta Ananian, Lillian Roberts, Russel J.
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Published in
American Journal of Nephrology
Background: Continuous renal replacement therapy (CRRT) is commonly employed in the intensive care unit (ICU), though there are no guidelines around the transition between CRRT and intermittent hemodialysis (iHD). Accelerated venovenous hemofiltration (AVVH) is a modality utilizing higher hemofiltration rates (4–5 L/h) with shorter session duration...
Gil-Ortega, Marta Vega-Martín, Elena Martín-Ramos, Miriam González-Blázquez, Raquel Pulido-Olmo, Helena Ruiz-Hurtado, Gema Schulz, Angela Ruilope, Luis M. Kolkhof, Peter Somoza, Beatriz
...
Published in
American Journal of Nephrology
Background: Development of albuminuria and arterial stiffness in Munich Wistar Frömter (MWF) rats, a model of chronic kidney disease, is related to alterations in extracellular matrix, increased oxidative stress, and endothelial dysfunction. Finerenone (FIN), a novel, nonsteroidal, potent, and selective mineralocorticoid receptor antagonist, improv...
Hines, Abigail Li, Xilong Ortiz-Soriano, Victor Saleh, Sherif Litteral, Jamie Ruiz-Conejo, Marice Wald, Ron Silver, Samuel A. Neyra, Javier A.
Published in
American Journal of Nephrology
Background: Persistence of acute kidney disease (AKD) after an episode of acute kidney injury (AKI) is associated with adverse outcomes. Multiple factors contribute to AKD after AKI, but the role of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB) remains controversial. We examined if acute exposure to an ACEI/AR...
