Wilkinson, Patrick D Alencastro, Frances Delgado, Evan R Leek, Madeleine P Weirich, Matthew P Otero, P Anthony Roy, Nairita Brown, Whitney K Oertel, Michael Duncan, Andrew W
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Published in
The American journal of pathology
The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice. Polyploid hepatocytes form multipolar spindles in mitosis, which lead to chromosome gains/losses and random aneuploidy. The effect of aneuploidy on liver function is unclear, and the degree ...
Meher, Akshaya K Johnston, William F Lu, Guanyi Pope, Nicolas H Bhamidipati, Castigliano M Harmon, Daniel B Su, Gang Zhao, Yunge McNamara, Coleen A Upchurch, Gilbert R Jr
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Published in
The American journal of pathology
Recent reports of rupture in patients with abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of understanding the role of B cells (B1 and B2 subsets) in the development of AAA. We hypothesized that B2 cells aggravate experimental aneurysm formation. The IHC staining revealed infiltration of B cells in the a...
Liantonio, Antonella Camerino, Giulia M Scaramuzzi, Antonia Cannone, Maria Pierno, Sabata De Bellis, Michela Conte, Elena Fraysse, Bodvael Tricarico, Domenico Conte Camerino, Diana
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Published in
The American journal of pathology
Hypertension is often associated with skeletal muscle pathological conditions related to function and metabolism. The mechanisms underlying the development of these pathological conditions remain undefined. Because calcium homeostasis is a biomarker of muscle function, we assessed whether it is altered in hypertensive muscles. We measured resting i...
Xia, Hong Bodem, Vidya Benyumov, Alexey Hergert, Polla Tank, Damien Herrera, Jeremy Braziunas, Jeff Larsson, Ola Parker, Matthew Rossi, Daniel
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Published in
The American Journal of Pathology
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly with a prevalence of one million persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli, creating a reticular network that leads to death by asphyxiation. Lung fibroblasts from patients with IPF have phenotypic hallmarks, disti...
Quan, Taihao Xu, Yiru Qin, Zhaoping Robichaud, Patrick Betcher, Stephanie Calderone, Ken He, Tianyuan Johnson, Timothy M. Voorhees, John J. Fisher, Gary J.
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Published in
The American Journal of Pathology
Yes-associated protein (YAP) is a transcriptional co-activator of hippo signaling pathway, which plays an important role in organ size control and tumorigenesis. Here we report that YAP and its downstream transcriptional targets CCN1 and CCN2 are markedly elevated in keratinocytes in human skin basal cell carcinoma tumor islands. In human keratinoc...
Toba, Michie Alzoubi, Abdallah O’Neill, Kealan Abe, Kohtaro Urakami, Takeo Komatsu, Masanobu Alvarez, Diego Järvinen, Tero A.H. Mann, David Ruoslahti, Erkki
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Published in
The American Journal of Pathology
A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is the lack of pulmonary vascular selectivity. Recent studies have identified a tissue-penetrating homing peptide, CARSKNKDC (CAR), which specifically homes to hypertensive pulmonary arteries but not to normal pulmonary vessels or other tissues. Some tissue...
Shime, Hiroaki Kojima, Ayako Maruyama, Akira Saito, Yusuke Oshiumi, Hiroyuki Matsumoto, Misako Seya, Tsukasa
Published in
Journal of Innate Immunity
Polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA, acts on myeloid cells and induces potent antitumor immune responses including natural killer (NK) cell activation. Myeloid-derived suppressor cells (MDSCs) systemically exist in tumor-bearing hosts and have strong immunosuppressive activity against antitumor effector cells...
Fernández, Patricia Perez-Aso, Miguel Smith, Gideon Wilder, Tuere Trzaska, Sean Chiriboga, Luis Franks, Andrew Jr. Robson, Simon C. Cronstein, Bruce N. Chan, Edwin S.L.
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Published in
The American Journal of Pathology
Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A2AR) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphosphate diphosphohydrolase (CD39) and ecto-5′-nucleoti...
Yang, Jibing Wheeler, Sarah E. Velikoff, Miranda Kleaveland, Kathryn R. LaFemina, Michael J. Frank, James A. Chapman, Harold A. Christensen, Paul J. Kim, Kevin K.
Published in
The American Journal of Pathology
Fibrosis is characterized by accumulation of activated fibroblasts and pathological deposition of fibrillar collagens. Activated fibroblasts overexpress matrix proteins and release factors that promote further recruitment of activated fibroblasts, leading to progressive fibrosis. The contribution of epithelial cells to this process remains unknown....
Fang, Feng Shangguan, Anna J. Kelly, Kathleen Wei, Jun Gruner, Katherine Ye, Boping Wang, Wenxia Bhattacharyya, Swati Hinchcliff, Monique E. Tourtellotte, Warren G.
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Published in
The American Journal of Pathology
Members of the early growth response (Egr) gene family of transcription factors have nonredundant biological functions. Although Egr-3 is implicated primarily in neuromuscular development and immunity, its regulation and role in tissue repair and fibrosis has not been studied. We now show that in normal skin fibroblasts, Egr-3 was potently induced ...
