Gaubert, Malo Lange, Catharina Garnier-Crussard, Antoine Köbe, Theresa Bougacha, Salma Gonneaud, Julie de Flores, Robin Tomadesso, Clémence Mézenge, Florence Landeau, Brigitte
...
Published in
Alzheimer's Research & Therapy
BackgroundWhite matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH asso...
Carles, Sophie Taddé, Bachirou O. Berr, Claudine Helmer, Catherine Jacqmin-Gadda, Hélène Carrière, Isabelle Proust-Lima, Cécile
Published in
Alzheimer's Research & Therapy
Background Thoroughly understanding the temporal associations between cognitive and functional dimensions along the dementia process is fundamental to define preventive measures likely to delay the disease’s onset. This work aimed to finely describe the trajectories of cognitive and functional declines, and assess their dynamic bidirectional relati...
Katayama, Takayuki Sawada, Jun Takahashi, Kae Yahara, Osamu Hasebe, Naoyuki
Published in
Alzheimer's Research & Therapy
Background This study examined the usefulness of cerebrospinal fluid (CSF) neuron-specific enolase (NSE) levels as a candidate biomarker of neurodegeneration in Alzheimer’s disease (AD), Parkinson’s disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Methods We performed a systematic search of P...
Kim, Jun Pyo Kim, Bo-Hyun Bice, Paula J. Seo, Sang Won Bennett, David A. Saykin, Andrew J. Nho, Kwangsik
Published in
Alzheimer's Research & Therapy
Background Accumulating evidence suggests that BMI1 confers protective effects against Alzheimer’s disease (AD). However, the mechanism remains elusive. Based on recent pathophysiological evidence, we sought for the first time to identify genetic variants in BMI1 as associated with AD biomarkers, including amyloid-β. Methods We used genetic, longit...
Grueso, Sergio Viejo-Sobera, Raquel
Published in
Alzheimer's Research & Therapy
Background An increase in lifespan in our society is a double-edged sword that entails a growing number of patients with neurocognitive disorders, Alzheimer’s disease being the most prevalent. Advances in medical imaging and computational power enable new methods for the early detection of neurocognitive disorders with the goal of preventing or red...
Targa, Adriano D. S. Benítez, Iván D. Dakterzada, Faridé Fontenele-Araujo, John Minguez, Olga Zetterberg, Henrik Blennow, Kaj Barbé, Ferran Piñol-Ripoll, Gerard
Published in
Alzheimer's Research & Therapy
Background Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer’s disease (AD), possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated with worse outcomes once individuals are diagnosed with symptomatic disease. We aimed to evaluate the association between the circa...
Van Egroo, Maxime van Hooren, Roy W. E. Jacobs, Heidi I. L.
Published in
Alzheimer's Research & Therapy
Background The brainstem locus coeruleus (LC) constitutes the intersection of the initial pathophysiological processes of Alzheimer’s disease (AD) and sleep-wake dysregulation in the preclinical stages of the disease. However, the interplay between in vivo assessment of LC degeneration and AD-related sleep alterations remains unknown. Here, we soug...
Huang, Shu-Yi Yang, Yu-Xiang Kuo, Kevin Li, Hong-Qi Shen, Xue-Ning Chen, Shi-Dong Cui, Mei Tan, Lan Dong, Qiang Yu, Jin-Tai
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Published in
Alzheimer's Research & Therapy
Background Observational studies have suggested that herpesvirus infection increased the risk of Alzheimer’s disease (AD), but it is unclear whether the association is causal. The aim of the present study is to evaluate the causal relationship between four herpesvirus infections and AD. Methods We performed a two-sample Mendelian randomization anal...
De Kort, Anna M. Kuiperij, H. Bea Alcolea, Daniel Kersten, Iris Versleijen, Alexandra A. M. Greenberg, Steven M. Stoops, Erik Schreuder, Floris H. B. M. Klijn, Catharina J. M. Lleó, Alberto
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Published in
Alzheimer's Research & Therapy
Background Neuroleukin (NLK) is a protein with neurotrophic properties and is present in a proportion of senile plaques and amyloid laden vessels. It has been suggested that NLK is part of a neuroprotective response to amyloid β-induced cell death. The aim of our study was to investigate the value of cerebrospinal fluid (CSF) NLK levels as a biomar...
Coley, Nicola Coniasse-Brioude, Delphine Igier, Valérie Fournier, Tristan Poulain, Jean-Pierre Andrieu, Sandrine Andrieu, Sandrine Coley, Nicola Gardette, Virginie Grand, Alain
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Published in
Alzheimer's Research & Therapy
Background Preventive interventions for dementia are urgently needed and must be tested in randomised controlled trials (RCTs). Selection (volunteer) bias may limit efficacy, particularly in trials testing multidomain interventions and may also be indicative of disparities in intervention uptake in real-world settings. We identified factors associa...
