Noveir, Sasan D. Kerman, Bilal E. Xian, Haotian Meuret, Cristiana Smadi, Sabrina Martinez, Ashley E. Johansson, Johannes Zetterberg, Henrik Parks, Bryan A. Kuklenyik, Zsuzsanna
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Published in
Alzheimer's Research & Therapy
Background Inducing brain ATP-binding cassette 1 (ABCA1) activity in Alzheimer’s disease (AD) mouse models is associated with improvement in AD pathology. The purpose of this study was to investigate the effects of the ABCA1 agonist peptide CS-6253 on amyloid-β peptides (Aβ) and lipoproteins in plasma and cerebrospinal fluid (CSF) of cynomolgus mon...
Yamashita, Kazuto Miura, Masahiro Watanabe, Shunsuke Ishiki, Kengo Arimatsu, Yuji Kawahira, Junko Kubo, Toshiko Sasaki, Katsutaka Arai, Takayuki Hagino, Kei
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Published in
Alzheimer's Research & Therapy
Background Clinicians, researchers, and patients alike would greatly benefit from more accessible and inexpensive biomarkers for neural β-amyloid (Aβ). We aimed to assess the performance of fully automated plasma Aβ immunoassays, which correlate significantly with immunoprecipitation mass spectrometry assays, in predicting brain Aβ status as determ...
Clark, Lindsay R. Erickson, Claire M. Jonaitis, Erin M. Ma, Yue Chin, Nathaniel A. Basche, Kristin Ketchum, Frederick B. Gleason, Carey E.
Published in
Alzheimer's Research & Therapy
Introduction We developed the Alzheimer’s Biomarker Survey to assess willingness to enroll in biomarker studies that disclose results and anticipated reactions to an elevated biomarker result. Methods Participants included cognitively unimpaired adults enrolled in longitudinal AD studies ( n = 334, mean age = 64.8 ± 7.7, 44% non-Hispanic Black or A...
Stepanov, Yurii V. Golovynska, Iuliia Zhang, Renlong Golovynskyi, Sergii Stepanova, Liudmyla I. Gorbach, Oleksandr Dovbynchuk, Taisa Garmanchuk, Liudmyla V. Ohulchanskyy, Tymish Y. Qu, Junle
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Published in
Alzheimer's Research & Therapy
Background Low-intensity light can decelerate neurodegenerative disease progression and reduce amyloid β (Aβ) levels in the cortex, though the cellular and molecular mechanisms by which photobiomodulation (PBM) protects against neurodegeneration are still in the early stages. Microglia cells play a key role in the pathology of Alzheimer’s disease b...
Kim, Hyewon Yoo, Juhwan Han, Kyungdo Lee, Dong-Yun Fava, Maurizio Mischoulon, David Jeon, Hong Jin
Published in
Alzheimer's research & therapy
The literature has shown depression to be associated with an increased risk of dementia. In addition, hormone therapy can be a responsive treatment option for a certain type of depression. In this study, we examined the association between hormone therapy, including lifetime oral contraceptive (OC) use, and hormone replacement therapy (HRT) after m...
Groot, Colin Cicognola, Claudia Bali, Divya Triana-Baltzer, Gallen Dage, Jeffrey L. Pontecorvo, Michael J. Kolb, Hartmuth C. Ossenkoppele, Rik Janelidze, Shorena Hansson, Oskar
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Published in
Alzheimer's Research & Therapy
Wirth, Miranka Schwarz, Claudia Benson, Gloria Horn, Nora Buchert, Ralph Lange, Catharina Köbe, Theresa Hetzer, Stefan Maglione, Marta Michael, Eva
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Published in
Alzheimer's Research & Therapy
Rejc, Luka Gómez-Vallejo, Vanessa Joya, Ana Arsequell, Gemma Egimendia, Ander Castellnou, Pilar Ríos-Anglada, Xabier Cossío, Unai Baz, Zuriñe Iglesias, Leyre
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Published in
Alzheimer's Research & Therapy
Background Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation biomarkers, such as translocator protein (TSPO) and cystine/glutamine antiporter system (xc-), could be considered when assessing AD pro...
López-Cuenca, Inés Marcos-Dolado, Alberto Yus-Fuertes, Miguel Salobrar-García, Elena Elvira-Hurtado, Lorena Fernández-Albarral, José A. Salazar, Juan J. Ramírez, Ana I. Sánchez-Puebla, Lidia Fuentes-Ferrer, Manuel Enrique
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Published in
Alzheimer's Research & Therapy
Background Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD. Methods We performed a cross-sectional study with 30 participants without a family history of sporadic AD (FH−) and...
Nilsson, Johanna Ashton, Nicholas J. Benedet, Andrea L. Montoliu-Gaya, Laia Gobom, Johan Pascoal, Tharick A. Chamoun, Mira Portelius, Erik Jeromin, Andreas Mendes, Muriel
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Published in
Alzheimer's Research & Therapy
Background Synaptic dysfunction and degeneration are central to Alzheimer’s disease (AD) and have been found to correlate strongly with cognitive decline. Thus, studying cerebrospinal fluid (CSF) biomarkers reflecting synaptic degeneration, such as the presynaptic protein synaptosomal-associated protein 25 (SNAP-25), is of importance to better unde...
