Gagliardi, Geoffroy Houot, Marion Cacciamani, Federica Habert, Marie-Odile Dubois, Bruno Epelbaum, Stéphane Audrain, C. Auffret, A. Bakardjian, H. Baldacci, F.
...
Published in
Alzheimer's Research & Therapy
BackgroundLack of awareness of cognitive decline (ACD) has been described at the preclinical and prodromal stages of Alzheimer’s disease (AD). In this study, we introduced a meta-memory ratio (MMR) and explored how it is associated with neuroimaging AD biomarkers in asymptomatic individuals at risk for AD.MethodFour hundred forty-eight cognitively ...
Park, Sang-Seo Park, Hye-Sang Kim, Chang-Ju Kang, Hyun-Sik Kim, Dong-Hyun Baek, Seung-Soo Kim, Tae-Woon
Published in
Alzheimer's Research & Therapy
BackgroundExercise promotes brain health and improves cognitive functioning in the elderly, while 40-Hz light flickering through the visual cortex reduces amyloid beta (Aβ) by stabilizing gamma oscillation. We examined whether exercise was associated with hippocampus-mediated improvement in cognitive functioning in the 3xTg-Alzheimer’s disease (3xT...
Lessard, Christian B. Rodriguez, Edgardo Ladd, Thomas B. Minter, Lisa M. Osborne, Barbara A. Miele, Lucio Golde, Todd E. Ran, Yong
Published in
Alzheimer's Research & Therapy
Backgroundγ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subtle differences in PS1- and PS2-mediated cleavages of select substrates and slightly different potencies of PS1 ...
Ponjoan, Anna Garre-Olmo, Josep Blanch, Jordi Fages, Ester Alves-Cabratosa, Lia Martí-Lluch, Ruth Comas-Cufí, Marc Parramon, Dídac Garcia-Gil, María Ramos, Rafel
...
Published in
Alzheimer's Research & Therapy
BackgroundThe analysis of real-world data in clinical research is rising, but its use to study dementia subtypes has been hardly addressed. We hypothesized that real-world data might be a powerful tool to update AD epidemiology at a lower cost than face-to-face studies, to estimate the prevalence and incidence rates of AD in Catalonia (Southern Eur...
Wu, Helen Zong Ying Thalamuthu, Anbupalam Cheng, Lesley Fowler, Christopher Masters, Colin L. Sachdev, Perminder Mather, Karen A.
Published in
Alzheimer's Research & Therapy
BackgroundPeripheral blood microRNAs (miRNA) have been identified as potential biomarkers for Alzheimer’s disease (AD). Study results have generally been inconsistent and limited by sample heterogeneity. The aim of this study is to establish candidate blood miRNA biomarkers for AD by comparing differences in miRNA expression between participants wi...
Novak, Gerald Streffer, Johannes Rolf Timmers, Maarten Henley, David Brashear, H. Robert Bogert, Jennifer Russu, Alberto Janssens, Luc Tesseur, Ina Tritsmans, Luc
...
Published in
Alzheimer's Research & Therapy
BackgroundAtabecestat, a potent brain-penetrable inhibitor of BACE1 activity that reduces CSF amyloid beta (Aβ), was developed for oral treatment for Alzheimer’s disease (AD).The long-term safety and effect of atabecestat on cognitive performance in participants with predementia AD in two phase 2 studies were assessed.MethodsIn the placebo-controll...
Ehrenberg, Alexander J. Khatun, Ayesha Coomans, Emma Betts, Matthew J. Capraro, Federica Thijssen, Elisabeth H. Senkevich, Konstantin Bharucha, Tehmina Jafarpour, Mehrsa Young, Peter N. E.
...
Published in
Alzheimer's Research & Therapy
BackgroundThe panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths...
Tan, Meng-Shan Ji, Xi Li, Jie-Qiong Xu, Wei Wang, Hui-Fu Tan, Chen-Chen Dong, Qiang Zuo, Chuan-Tao Tan, Lan Suckling, John
...
Published in
Alzheimer's Research & Therapy
BackgroundModels of Alzheimer’s disease (AD) pathophysiology posit that amyloidosis [A] precedes and accelerates tau pathology [T] that leads to neurodegeneration [N]. Besides this A-T-N sequence, other biomarker sequences are possible. This current work investigates and compares the longitudinal trajectories of Alzheimer’s ATN biomarker profiles i...
Gallart-Palau, Xavier Guo, Xue Serra, Aida Sze, Siu Kwan
Published in
Alzheimer's Research & Therapy
BackgroundThe contributions of brain intercellular communication mechanisms, specifically extracellular vesicles (EV), to the progression of Alzheimer’s disease (AD) remain poorly understood.MethodsHere, we investigated the role(s) of brain EV in the progressive course of AD through unbiased proteome-wide analyses of temporal lobe-derived EV and pr...
Liguori, Claudio Placidi, Fabio Izzi, Francesca Spanetta, Matteo Mercuri, Nicola Biagio Di Pucchio, Alessandra
Published in
Alzheimer's Research & Therapy
An amendment to this paper has been published and can be accessed via the original article.
