Belloy, Michael E. Eger, Sarah J. Le Guen, Yann Damotte, Vincent Ahmad, Shahzad Ikram, M. Arfan Ramirez, Alfredo Tsolaki, Anthoula C. Rossi, Giacomina Jansen, Iris E.
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Published in
Alzheimer's Research & Therapy
BackgroundGenetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of APOE pathophysiology and provide critical guidance for AD therapies aimed at APOE. The APOE locus however remai...
Dautricourt, Sophie Gonneaud, Julie Landeau, Brigitte Calhoun, Vince D. de Flores, Robin Poisnel, Géraldine Bougacha, Salma Ourry, Valentin Touron, Edelweiss Kuhn, Elizabeth
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Published in
Alzheimer's Research & Therapy
Background This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. Methods DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and bi...
Zhong, Claire C. W. Zhao, Jinglun Wong, Charlene H. L. Wu, Irene X. Y. Mao, Chen Yeung, Jerry W. F. Chung, Vincent C. H.
Published in
Alzheimer's Research & Therapy
Background Carefully conducted systematic reviews (SRs) can provide reliable evidence on the effectiveness of treatment strategies for Alzheimer’s disease (AD). Nevertheless, the reliability of SR results can be limited by methodological flaws. This cross-sectional study aimed to examine the methodological quality of SRs on AD treatments, along wit...
Jo, Kyung Won Lee, Dohyun Cha, Dong Gon Oh, Eunji Choi, Yoon Ha Kim, Somi Park, Eun Seo Kim, Jong Kyoung Kim, Kyong-Tai
Published in
Alzheimer's Research & Therapy
Background Microglia are the resident immune cells found in our brain. They have a critical role in brain maintenance. Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Aβ. Through phagocytosis of Aβ, microglia prevent the accumulation of Aβ plaque in the brain. However, in Alzheimer’s dis...
Kim, Soo-Jong Ham, Hongki Park, Yu Hyun Choe, Yeong Sim Kim, Young Ju Jang, Hyemin Na, Duk L. Kim, Hee Jin Moon, Seung Hwan Seo, Sang Won
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Published in
Alzheimer's Research & Therapy
Background The standard Centiloid (CL) method was proposed to harmonize and quantify global 18F-labeled amyloid beta (Aβ) PET ligands using MRI as an anatomical reference. However, there is need for harmonizing and quantifying regional Aβ uptakes between ligands using CT as an anatomical reference. In the present study, we developed and validated a...
Wang, Yue Wang, Shinan Zhu, Wanlin Liang, Na Zhang, Chen Pei, Yuankun Wang, Qing Li, Shiping Shi, Jiong
Published in
Alzheimer's Research & Therapy
Background The incidence of cognitive impairment is increasing with an aging population. Developing effective strategies is essential to prevent dementia. Higher education level is associated with better baseline cognitive performance, and reading activities can slow down cognitive decline. However, it is unclear whether education and reading activ...
Benussi, Alberto Cantoni, Valentina Rivolta, Jasmine Archetti, Silvana Micheli, Anna Ashton, Nicholas Zetterberg, Henrik Blennow, Kaj Borroni, Barbara
Published in
Alzheimer's Research & Therapy
Background In the last decade, non-invasive blood-based and neurophysiological biomarkers have shown great potential for the discrimination of several neurodegenerative disorders. However, in the clinical workup of patients with cognitive impairment, it will be highly unlikely that any biomarker will achieve the highest potential predictive accurac...
Low, Audrey Prats-Sedano, Maria A McKiernan, Elizabeth Carter, Stephen F Stefaniak, James D Nannoni, Stefania Su, Li Dounavi, Maria-Eleni Muniz-Terrera, Graciela Ritchie, Karen
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Published in
Alzheimer's research & therapy
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white matter hyperintensities) already co-exist. In younger asymptomatic adults, we investigated differential associations and in...
Baiardi, Simone Quadalti, Corinne Mammana, Angela Dellavalle, Sofia Zenesini, Corrado Sambati, Luisa Pantieri, Roberta Polischi, Barbara Romano, Luciano Suffritti, Matteo
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Published in
Alzheimer's Research & Therapy
Background Increasing evidence supports the use of plasma biomarkers of neurodegeneration and neuroinflammation to screen and diagnose patients with dementia. However, confirmatory studies are required to demonstrate their usefulness in the clinical setting. Methods We evaluated plasma and cerebrospinal fluid (CSF) samples from consecutive patients...
Ebright, Brandon Assante, Isaac Poblete, Roy A Wang, Shaowei Duro, Marlon V Bennett, David A Arvanitakis, Zoe Louie, Stan G Yassine, Hussein N
Published in
Alzheimer's research & therapy
Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer's disease (AD) dementia pathogenesis. Carrying the apolipoprotein ε4 (APOE4) allele has been associated with an accentuated response to brain inflammation and increases the risk of AD dementia progression. Among inflammation signaling pathways, aberrant eicosanoid activation ...
