Li, Hong-Dong Funk, Cory C McFarland, Karen Dammer, Eric B Allen, Mariet Carrasquillo, Minerva M Levites, Yona Chakrabarty, Paramita Burgess, Jeremy D Wang, Xue
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Intron retention (IR) has been implicated in the pathogenesis of complex diseases such as cancers; its association with Alzheimer's disease (AD) remains unexplored. We performed genome-wide analysis of IR through integrating genetic, transcriptomic, and proteomic data of AD subjects and mouse models from the Accelerating Medicines Partnership-Alzhe...
Datta, Dibyadeep Leslie, Shannon N Wang, Min Morozov, Yury M Yang, Shengtao Mentone, SueAnn Zeiss, Caroline Duque, Alvaro Rakic, Pasko Horvath, Tamas L
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
The etiology of sporadic Alzheimer's disease (AD) requires non-genetically modified animal models. The relationship of tau phosphorylation to calcium-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) dysregulation was analyzed in aging rhesus macaque dorsolateral prefrontal cortex (dlPFC) and rat primary cortical neurons using biochemist...
Malpetti, Maura Jones, P Simon Tsvetanov, Kamen A Rittman, Timothy van Swieten, John C Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical a...
Kinchin, Irina Mitchell, Eileen Agar, Meera Trépel, Dominic
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
This review aims to systematically identify and appraise the methodological quality of claims on the cost of delirium; and discuss challenges and opportunities for improvements in the precision of the estimates. Searches of scientific papers and gray literature were performed up until June 2020. The Larg and Moss checklist was used to assess the me...
Agudelo, Christian Tarraf, Wassim Wu, Benson Wallace, Douglas M Patel, Sanjay R Redline, Susan Kaur, Sonya Daviglus, Martha Zee, Phyllis C Simonelli, Guido
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of ...
Elman, Jeremy A Puckett, Olivia K Beck, Asad Fennema-Notestine, Christine Cross, Latonya K Dale, Anders M Eglit, Graham M L Eyler, Lisa T Gillespie, Nathan A Granholm, Eric L
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensit...
de Erausquin, Gabriel A Snyder, Heather Carrillo, María Hosseini, Akram A Brugha, Traolach S Seshadri, Sudha
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
The increasing evidence of SARS-CoV-2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. The Alzheimer's Association and representatives from more than 30 countries-with technical guidance from the World Health Organization-have formed...
Luckett, Patrick H McCullough, Austin Gordon, Brian A Strain, Jeremy Flores, Shaney Dincer, Aylin McCarthy, John Kuffner, Todd Stern, Ari Meeker, Karin L
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Machine learning models were used to discover novel disease trajectories for autosomal dominant Alzheimer's disease. Longitudinal structural magnetic resonance imaging, amyloid positron emission tomography (PET), and fluorodeoxyglucose PET were acquired in 131 mutation carriers and 74 non-carriers from the Dominantly Inherited Alzheimer Network; th...
Frye, Brett M Craft, Suzanne Register, Thomas C Andrews, Rachel N Appt, Susan E Vitolins, Mara Z Uberseder, Beth Silverstein-Metzler, Marnie G Chen, Haiying Whitlow, Christopher T
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Associations between diet, psychosocial stress, and neurodegenerative disease, including Alzheimer's disease (AD), have been reported, but causal relationships are difficult to determine in human studies. We used structural magnetic resonance imaging in a well-validated non-human primate model of AD-like neuropathology to examine the longitudinal e...
Llibre-Guerra, Jorge J Li, Yan Allegri, Ricardo F Mendez, Patricio Chrem Surace, Ezequiel I Llibre-Rodriguez, Juan J Sosa, Ana Luisa Aláez-Verson, Carmen Longoria, Erika-Mariana Tellez, Alberto
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country remain open. A literature review was completed aimed to provide estimates for DIAD pathogenic variants in the LatAm population. The search ...
