O'Bryant, Sid E Petersen, Melissa Hall, James Johnson, Leigh A
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Despite the clinical implementation, there remain significant gaps in our knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma Alzheimer's disease (AD) biomarkers. Plasma biomarkers of amyloid beta (Aβ)40, Aβ42 , total tau, and neurofilament light chain (NfL) were measured across cognitively normal Mexican Americ...
Hsu, Chi-Kuei Lai, Chih-Cheng
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Luckett, Patrick H Chen, Charlie Gordon, Brian A Wisch, Julie Berman, Sarah B Chhatwal, Jasmeer P Cruchaga, Carlos Fagan, Anne M Farlow, Martin R Fox, Nick C
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
As the number of biomarkers used to study Alzheimer's disease (AD) continues to increase, it is important to understand the utility of any given biomarker, as well as what additional information a biomarker provides when compared to others. We used hierarchical clustering to group 19 cross-sectional biomarkers in autosomal dominant AD. Feature sele...
Liu, Lei Lauro, Bianca M He, Amy Lee, Hyo Bhattarai, Sanjay Wolfe, Michael S Bennett, David A Karch, Celeste M Young-Pearse, Tracy Selkoe, Dennis J
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Identifying CSF-based biomarkers for the β-amyloidosis that initiates Alzheimer's disease (AD) could provide inexpensive and dynamic tests to distinguish AD from normal aging and predict future cognitive decline. We developed immunoassays specifically detecting all C-terminal variants of secreted amyloid β-protein and identified a novel biomarker, ...
Jacobs, Heidi I L Becker, John Alex Kwong, Kenneth Munera, Diana Ramirez-Gomez, Liliana Engels-Domínguez, Nina Sanchez, Justin S Vila-Castelar, Clara Baena, Ana Sperling, Reisa A
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored. We ...
Coe, Norma B White, Lindsay Oney, Melissa Basu, Anirban Larson, Eric B
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
We estimate the spending attributable to Alzheimer's disease and related dementias (ADRD) to the United States government for the first 5 years post-diagnosis. Using data from the Health and Retirement Study matched to Medicare and Medicaid claims, we identify a retrospective cohort of adults with a claims-based ADRD diagnosis along with matched co...
Zhang, Xiaoling Tong, Tong Chang, Andrew Ang, Ting Fang Alvin Tao, Qiushan Auerbach, Sanford Devine, Sherral Qiu, Wei Qiao Mez, Jesse Massaro, Joseph
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
It is unknown whether vascular and metabolic diseases assessed in early adulthood are associated with Alzheimer's disease (AD) later in life. Association of AD with lipid fractions, glucose, blood pressure, body mass index (BMI), and smoking obtained prospectively from 4932 Framingham Heart Study (FHS) participants across nine quadrennial examinati...
Ashleigh, Theophania Swerdlow, Russell H Beal, M Flint
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by progressive neuronal loss and biochemical abnormalities including mitochondrial dysfunction. Conventional thinking has dictated that AD is driven by amyloid beta pathology, p...
Fruijtier, Agnetha D van der Schaar, Jetske van Maurik, Ingrid S Zwan, Marissa D Scheltens, Philip Bouwman, Femke Pijnenburg, Yolande A L van Berckel, Bart N M Ebenau, Jarith van der Flier, Wiesje M
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Empirical studies on effective communication for amyloid disclosure in mild cognitive impairment (MCI) are lacking. We aimed to study the impact of six communication strategies. We performed a randomized controlled trial with seven randomly assigned, video-vignette conditions: six emphasizing a communication strategy and one basic condition. All sh...
Lozupone, Madia Imbimbo, Bruno Pietro Balducci, Claudia Lo Vecchio, Filomena Bisceglia, Paola Latino, Raffaela Rita Leone, Maurizio Dibello, Vittorio Solfrizzi, Vincenzo Greco, Antonio
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Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association
Human apolipoprotein E (apoE) is a 299-amino acid secreted glycoprotein binding cholesterol and phospholipids, and with three common isoforms (APOE ε2, APOE ε3, and APOE ε4). The exact mechanism by which APOE gene variants increase/decrease Alzheimer's disease (AD) risk is not fully understood, but APOE isoforms differently affect brain homeostasis...
