Published in Allergy, Asthma & Clinical Immunology
BackgroundInsulin hypersensitivity is rare, but challenging for individuals with diabetes. The prevalence of insulin allergy has decreased since the introduction of human recombinant insulin preparations. Hypersensitivity reactions range from injection site erythema and swelling, to anaphylaxis. While some reactions are to excipients (zinc, protami...
Published in Allergy, Asthma & Clinical Immunology
Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need...
Published in Allergy, Asthma & Clinical Immunology
BackgroundHereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibitor that is approved as 1st line therapy in Canada for long term prophylaxis of HAE attacks.ObjectiveTo describe our clinical findin...
Published in Allergy, Asthma & Clinical Immunology
PurposeBody mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma status and variation in DNAm is a consequence of BMI changes. This study assessed the direct and indirect (via DNAm) effects of BMI traject...
Published in Allergy, Asthma & Clinical Immunology
BackgroundShrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response.MethodsThirty-seven patients (18 male and 19 female) with a positive history of symptoms associated wi...
Published in Allergy, Asthma & Clinical Immunology
BackgroundCD8+CD25+fork-head box transcription factor (Foxp3)+ regulatory T cells (CD8+ Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study aimed to evaluate influences of CD8+ Tregs on inflammatory conditions in a murine model of AR.MethodsA murine model of AR was es...
Published in Allergy, Asthma & Clinical Immunology
BackgroundImmediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization.Case presentationA 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line trea...
Published in Allergy, Asthma & Clinical Immunology
Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injections. However, little is known about antibody penetration through the skin. The aim was to study the transcutaneous penetration of a reduced...
Published in Allergy, Asthma & Clinical Immunology
IntroductionWe conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians).ObjectiveTo examine the independent effect of demographic characteristics on food allergy.MethodsCanadian households with vulnerable populat...
Published in Allergy, Asthma & Clinical Immunology
Most Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and categorized/confirmed by allergists. A secondary aim was to describe severity of allergic reactions to emerging allergens. Parents reported alle...
