Mintz, Carrie M Hartz, Sarah M Fisher, Sherri L Ramsey, Alex T Geng, Elvin H Grucza, Richard A Bierut, Laura J
Published in
Alcoholism, clinical and experimental research
Although effective treatments exist, alcohol use disorder (AUD) is undertreated. We used a cascade of care framework to understand gaps in care for persons with AUD. Using 2015-2019 National Survey on Drug Use and Health data, we evaluated the following steps in the cascade of care: (1) adult prevalence of AUD; (2) proportion of adults with AUD who...
Stephenson, Mallory Bollepalli, Sailalitha Cazaly, Emma Salvatore, Jessica E Barr, Peter Rose, Richard J Dick, Danielle Kaprio, Jaakko Ollikainen, Miina
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Alcoholism, clinical and experimental research
DNA methylation may play a role in the progression from normative to problematic drinking and underlie adverse health outcomes associated with alcohol misuse. We examined the association between alcohol consumption and DNA methylation patterns using 3 approaches: a conventional epigenome-wide association study (EWAS); a co-twin comparison design, w...
Rockhold, Madeline N Krueger, Alyssa M de Water, Erik Lindgren, Christopher W Sandness, Kristin E Eckerle, Judith K Schumacher, Mariah J Fink, Birgit A Boys, Christopher J Carlson, Stephanie M
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Alcoholism, clinical and experimental research
Prenatal alcohol exposure (PAE) is linked to a variety of neurodevelopmental challenges, including social functioning (SF) and executive functioning (EF) deficits. These deficits present differently across developmental stages from preschool age to adolescence. The post hoc analyses described here were conducted on data from 83 preschool-age childr...
Bernes, Gemma A Villodas, Miguel Coles, Claire D Kable, Julie A May, Philip A Kalberg, Wendy O Sowell, Elizabeth R Jones, Kenneth L Riley, Edward P Mattson, Sarah N
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Alcoholism, clinical and experimental research
Rating scales are designed to complement traditional performance-based measures, and both can provide useful information about the functioning of youth with histories of prenatal alcohol exposure. Few studies, however, have compared ratings from multiple informants or the relationship between these subjective rating scale scores and the objective r...
Ramer, Nolan E Paige, Katie J Colder, Craig R
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Alcoholism, clinical and experimental research
There are mixed findings in the literature regarding the association between parental alcohol communication and offspring alcohol use. To clarify this association, this study tested a prospective mediated moderation model in which the association between parental communication about the risks of alcohol use and emerging adult offspring drinking was...
Stevens, Angela K Aston, Elizabeth R Gunn, Rachel L Sokolovsky, Alexander W Treloar Padovano, Hayley White, Helene R Jackson, Kristina M
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Alcoholism, clinical and experimental research
Alcohol and marijuana/cannabis are frequently used simultaneously (i.e., SAM use). SAM use is complex, and the ways in which alcohol and cannabis are simultaneously used may reveal differential effects. The purpose of this study was to examine day-level effects of distinct alcohol and cannabis product combinations on simultaneous use and consequenc...
Kang, Seung Joo Shin, Cheol Min Sung, Joohon Kim, Nayoung
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Alcoholism, clinical and experimental research
Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2. The aim of this meta-analysis was to evaluate whether ALDH2 polymorphism can affect alcohol-induced gastric carcinogenesis. We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2...
Pavon, Francisco J. Polis, Ilham Stouffer, David G. Roberto, Marisa Martin-Fardon, Rémi de Fonseca, Fernando Rodriguez Parsons, Loren H. Serrano, Antonia
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Alcoholism, clinical and experimental research
Background: Ethanol (EtOH) self-administration is particularly sensitive to the modulation of CB1 signaling in the nucleus accumbens (NAc) shell, and EtOH consumption increases extracellular levels of the endogenous cannabinoid CB1 receptor agonist 2-arachidonoyl glycerol (2-AG) in this brain region. Stimulation of CB1 receptor with agonists increa...
Kenton, Johnny A Castillo, Victoria K Kehrer, Penelope E Brigman, Jonathan L
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Alcoholism, clinical and experimental research
Exposure to high levels of alcohol during development leads to alterations in neurogenesis and deficits in hippocampal-dependent learning. Evidence suggests that even more moderate alcohol consumption during pregnancy can have negative impacts on the cognitive function of offspring. Methods for assessing impairments differ greatly across species, c...
Anton, Raymond F Voronin, Konstantin E Book, Sarah W Latham, Patricia K Randall, Patrick K Glen, Willam Bailey Hoffman, Michaela Schacht, Joseph P
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Alcoholism, clinical and experimental research
While the opiate antagonist, naltrexone, is approved for treating alcohol use disorder (AUD), not everyone who receives the medication benefits from it. This study evaluated whether the OPRM1 SNP rs1799971 interacts with the dopamine transporter gene DAT1/SLC6A3 VNTR rs28363170 or the catechol-O-methyltransferase (COMT) gene SNP rs4680 in predictin...
