Dodge, Neil C Thomas, Kevin G F Meintjes, Ernesta M Molteno, Christopher D Jacobson, Joseph L Jacobson, Sandra W
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Alcoholism, clinical and experimental research
Prenatal alcohol exposure (PAE) has been linked to poorer performance on the Morris water maze (MWM), a test of spatial navigation in rodents that is dependent on hippocampal functioning. We recently confirmed these findings in children with PAE on a human analog of the MWM, the virtual water maze (VWM). Previous studies have shown that the hippoca...
Varlamov, Oleg Bucher, Matthew Myatt, Leslie Newman, Natali Grant, Kathleen A
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Alcoholism, clinical and experimental research
Unhealthy consumption of alcohol is a major public health crisis with strong associations between immunological dysfunctions, high vulnerability to infectious disease, anemia, and an increase in the risk of hematological malignancies. However, there is a lack of studies addressing alcohol-induced changes in bone marrow (BM) and hematopoiesis as fun...
Xu, Wenhua Li, Hui He, Caigu Frank, Jacqueline Chen, Gang
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Alcoholism, clinical and experimental research
Alcohol consumption during pregnancy may damage the developing central nervous system of the fetus and lead to brain structural and functional deficits in the children, known as fetal alcohol spectrum disorders. The underlying mechanisms have not been fully elucidated. Previously, using a third trimester-equivalent mouse model, ethanol (EtOH)-induc...
Rosenthal, Annika Beck, Anne Zois, Evangelos Vollstädt-Klein, Sabine Walter, Henrik Kiefer, Falk Lohoff, Falk W Charlet, Katrin
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Alcoholism, clinical and experimental research
Aspects of self-control such as sensation seeking and impaired impulse control have been implicated in alcohol dependence (ALC). Conversely, sensation seeking has been ascribed a possible protective role in stress-related psychopathologies. We therefore examined gray matter (GM) morphology in individuals with ALC, focusing on differences in prefron...
Peterson, Hope Simpson, Sean L Laurienti, Paul J
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Alcoholism, clinical and experimental research
The study of alcohol use frequency utilizes alcohol-related cue imagery. Although a number of alcohol-image databases currently exist, they have several limitations: Many are not publicly available, some use stock images or clip art rather than real photographs, several eliminate any photographs displaying brand information, and predominantly they ...
Joyner, Keanan J Meshesha, Lidia Z Dennhardt, Ashley A Borsari, Brian Martens, Matthew P Murphy, James G
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Alcoholism, clinical and experimental research
Behavioral economic theory views addiction as a reinforcer pathology characterized by excessive demand for drugs relative to alternatives. Complementary to this theory, Lamb and Ginsburg (Pharmacology Biochemistry and Behavior, 164, 2018, 62) describe addiction as a behavioral allocation disorder and predict that decisions to drink under increasing...
Chambers, Christina D Coles, Claire Kable, Julie Akshoomoff, Natacha Xu, Ronghui Zellner, Jennifer A Honerkamp-Smith, Gordon Manning, Melanie A Adam, Margaret P Jones, Kenneth Lyons
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Alcoholism, clinical and experimental research
There are limited data on the characteristics of children with fetal alcohol spectrum disorders (FASD) and their mothers from the general population in the United States. During the 2012 and 2013 academic years, first-grade children in a large urban Pacific Southwest city were invited to participate in a study to estimate the prevalence of FASD. Ch...
Stasiewicz, Paul R Bradizza, Clara M Ruszczyk, Melanie U Lucke, Joseph F Zhao, Junru Linn, Braden Slosman, Kim S Dermen, Kurt H
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Alcoholism, clinical and experimental research
Few studies have focused on behavioral changes that occur prior to entering treatment for an alcohol use disorder (AUD). In 2 studies (Psychol Addict Behav, 27, 2013, 1159; J Stud Alcohol, 66, 2005, 369), pretreatment reductions in alcohol use were associated with better treatment outcomes. Identifying patterns of pretreatment change has the potent...
Stauffer, Christopher S Meinzer, Nathan K Morrison, Tyler Wen, Jin-Hui Radanovich, Lily Leung, David Niles, Andrea O'Donovan, Aoife Batki, Steven L Woolley, Joshua D
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Alcoholism, clinical and experimental research
Individuals with alcohol use disorder (AUD) are much more likely to meet criteria for posttraumatic stress disorder (PTSD) than the general population. Compared to AUD alone, those with comorbid AUD-PTSD experience worse outcomes. Prior literature suggests that oxytocin, a hypothalamic neuropeptide, may be effective in the treatment of both AUD and...
Adong, Julian Fatch, Robin Emenyonu, Nneka I Cheng, Debbie M Muyindike, Winnie R Ngabirano, Christine Kekibiina, Allen Woolf-King, Sarah E Samet, Jeffrey H Hahn, Judith A
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Alcoholism, clinical and experimental research
Self-report is widely used to assess alcohol use in research and clinical practice, but may be subject to social desirability bias. We aimed to determine if social desirability impacts self-reported alcohol use. Among 751 human immunodeficiency virus (HIV)-infected patients from a clinic in southwestern Uganda, we measured social desirability using...
