Liu, Dandan Zhang, Qian Luo, Piao Gu, Liwei Shen, Shengnan Tang, Huan Zhang, Ying Lyu, Ming Shi, Qiaoli Yang, Chuanbin
...
Published in
Aging and Disease
There are rarely new therapeutic breakthroughs present for neurodegenerative diseases in the last decades. Thus, new effective drugs are urgently needed for millions of patients with neurodegenerative diseases. Celastrol, a pentacyclic triterpenoid compound, is one of the main active ingredients isolated from Tripterygium wilfordii Hook. f. that ha...
Jiang, Li-Ping Yu, Xiao-Hua Chen, Jin-Zhi Hu, Mi Zhang, Yang-Kai Lin, Hui-Ling Tang, Wan-Ying He, Ping-Ping Ouyang, Xin-Ping
Published in
Aging and Disease
Atherosclerosis, the pathological basis of most cardiovascular disease, is characterized by plaque formation in the intima. Secondary lesions include intraplaque hemorrhage, plaque rupture, and local thrombosis. Vascular endothelial function impairment and smooth muscle cell migration lead to vascular dysfunction, which is conducive to the formatio...
Yu, Hang-Xing Feng, Zhe Lin, Wei Yang, Kang Liu, Rui-Qi Li, Jia-Qi Liu, Xin-Yue Pei, Ming Yang, Hong-Tao
Published in
Aging and Disease
Fibrosis is a pathological manifestation of wound healing that replaces dead/damaged tissue with collagen-rich scar tissue to maintain homeostasis, and complications from fibrosis contribute to nearly half of all deaths in the industrialized world. Ageing is closely associated with a progressive decline in organ function, and the prevalence of tiss...
Dehhaghi, Mona Panahi, Hamed Kazemi Shariat Kavyani, Bahar Heng, Benjamin Tan, Vanessa Braidy, Nady Guillemin, Gilles J.
Published in
Aging and Disease
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments accompanied by pervasive malaise that is exacerbated after physica...
Cui, Yanhui Wang, Xueqin Lin, Fengyu Li, Wen Zhao, Yuhao Zhu, Fei Yang, Hang Rao, Mingjun li, Yi Liang, Huaying
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Published in
Aging and Disease
Alveolar epithelial cell damage is an important determinant of the severity of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the molecular mechanisms of alveolar epithelial death during the development of ALI/ARDS remain unclear. In this study, we explore the role of miR-29a-3p in ALI/ARDS and its molecular mechanism. P...
Phillips, Matthew CL
Published in
Aging and Disease
Modern healthcare systems are founded on a disease-centric paradigm, which has conferred many notable successes against infectious disorders in the past. However, today’s leading causes of death are dominated by non-infectious “lifestyle” disorders, broadly represented by the metabolic syndrome, atherosclerosis, cancer, and neurodegeneration. Our d...
Machado, Marco
Published in
Aging and Disease
Zou, Yifei Song, Xianjing Liu, Ning Sun, Wei Liu, Bin
Published in
Aging and Disease
Although substantial progress has been made in reducing the burden of the disease by preventing the risk factors of cardiovascular disease (CVD), potential risk factors still exist and lead to its progression. In recent years, numerous studies have revealed that intestinal flora can interfere with the physiological processes of the host through cha...
Yang, Qiumei Chan, Piu
Published in
Aging and Disease
Sarcopenia is a new type of senile syndrome with progressive skeletal muscle mass loss with age, accompanied by decreased muscle strength and/or muscle function. Sarcopenia poses a serious threat to the health of the elderly and increases the burden of family and society. The underlying pathophysiological mechanisms of sarcopenia are still unclear....
Liu, Yuqing Chen, Xin Che, Yutong Li, Hongli Zhang, Zheyu Peng, Weijun Yang, Jingjing
Published in
Aging and Disease
Alzheimer’s disease (AD) is the most common type of dementia and a serious threat to the health and safety of the elderly population. It has become an emerging public health problem and a major economic and social burden. However, there is currently no effective treatment for AD. Although the mechanism of AD pathogenesis has been investigated subst...
