Al Abed, Alice Shaam Sellami, Azza Potier, Mylene Ducourneau, Eva‐Gunnel Gerbeaud‐Lassau, Pauline Brayda‐Bruno, Laurent Lamothe, Valerie Sans, Nathalie Desmedt, Aline Vanhoutte, Peter
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Published in
Aging Cell
Memorizing temporal association is associated with an extra‐synaptic redistribution of GluN2b‐containing NMDA receptors in young adult mice. A loss of such trafficking, leading to GluN2b synaptic accumulation, causes the age‐related memory deficit. Indeed, reducing GluN2b synaptic contents by inducing extra‐synaptic redistribution of these subunits...
Nehme, Jamil Borghesan, Michela Mackedenski, Sebastian Bird, Thomas G Demaria, Marco
Published in
Aging cell
SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising mortality particularly in individuals with advanced age. Identifying a functional association between SARS-CoV-2 infection an...
Wang, Feng Liu, Yan-Hou Zhang, Ting Gao, Jing Xu, Yangyue Xie, Guang-Yao Zhao, Wen-Jie Wang, Hongda Yang, Yong-Guang
Published in
Aging cell
CD47 serves as a ligand for signaling regulatory protein α (SIRPα) and as a receptor for thrombospondin-1 (TSP-1). Although CD47, TSP-1, and SIRPα are thought to be involved in the clearance of aged red blood cells (RBCs), aging-associated changes in the expression and interaction of these molecules on RBCs have been elusive. Using direct stochasti...
Santesmasses, Didac Castro, José Pedro Zenin, Aleksandr A. Shindyapina, Anastasia V. Gerashchenko, Maxim V. Zhang, Bohan Kerepesi, Csaba Yim, Sun Hee Fedichev, Peter O. Gladyshev, Vadim N.
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Published in
Aging Cell
This study establishes COVID‐19 as an emergent disease of aging, based on (a) an exponential growth of the COVID‐19 mortality rate with age, (b) the COVID‐19 mortality rate doubling time approaching that of all‐cause human mortality, (c) higher mortality in men than in women, (d) strong association with pre‐existing age‐related diseases, and (e) CO...
Oblong, John E. Bowman, Amy Rovito, Holly A. Jarrold, Bradley B. Sherrill, Joseph D. Black, Markaisa R. Nelson, Glyn Kimball, Alexa B. Birch‐Machin, Mark A.
Published in
Aging Cell
A decline in mitochondrial quality was observed in primary human skin fibroblasts with age, with a decrease in mitochondrial complex gene expression, oxidative phosphorylation rates, spare respiratory capacity, mitochondrial number, membrane potential, and mitophagy. The addition of Nam (nicotinamide, vitamin B3) improved these age‐related changes ...
Kawagoe, Yuta Kawashima, Ikko Sato, Yorino Okamoto, Naoki Matsubara, Kazuei Kawamura, Kazuhiro
Published in
Aging Cell
We identified CXCL5 as a senescence‐associated secretory phenotype (SASP) factors in preimplantation embryos, showing elevated expression in embryos of older women and mice. The implantation rate of CXCL5‐treated young embryos from mice was decreased due to suppression of trophoblast cell proliferation. In aging embryos, suppression of CXCL5‐CXCR2 ...
Zhao, Yue Zeng, Chen‐Ye Li, Xiao‐Hong Yang, Ting‐Ting Kuang, Xi Du, Jun‐Rong
Published in
Aging Cell
Klotho , as an anti‐aging gene, has been studied in the field of AD in recent years. Our data showed that Klotho overexpression inhibited NLRP3 inflammasome activation and promoted Aβ clearance through an increase in M2 type microglia and the regulation of Aβ transporters in APP/PS1 mice, which effectively relieved neuroinflammation and Aβ burden a...
del Llano, Edgar Masek, Tomas Gahurova, Lenka Pospisek, Martin Koncicka, Marketa Jindrova, Anna Jansova, Denisa Iyyappan, Rajan Roucova, Kristina Bruce, Alexander W.
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Published in
Aging Cell
Schematic model depicting that maternal age affects the translation of specific mRNAs in oocytes. Fully grown oocytes from different maternal age have similar transcriptomes at the GV stage. However, shortly after NEBD, some of these transcripts are not translated at the same level between YF and AF oocytes, such as Sgk1 , Aire , Castor1 and Eg5 . ...
Fang, Yixuan An, Ni Zhu, Lingjiang Gu, Yue Qian, Jiawei Jiang, Gaoyue Zhao, Ruijin Wei, Wen Xu, Li Zhang, Gaochuan
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Published in
Aging Cell
Autophagy collaborates with Sirt3, to form a regulatory axis that synergistically delays hematopoietic aging in both mice and humans. Positive intervention to the autophagy‐Sirt3 axis leads to blood rejuvenation.
Laurentino, Sandra Cremers, Jann‐Frederik Horsthemke, Bernhard Tüttelmann, Frank Czeloth, Karen Zitzmann, Michael Pohl, Eva Rahmann, Sven Schröder, Christopher Berres, Sven
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Published in
Aging Cell
In this study we found that healthy ageing in men is associated with a maintenance of normal sperm parameters and hormonal profiles, and maintenance of quality of life. In germ cells, a specific pattern of ageing is found, including increased telomere length, decreased DNA stability, and genome‐wide changes in DNA methylation. These changes to the ...
