Correction for: miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis...
Published in Aging
Correction for: ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen.
Published in Aging
Identification of key circadian rhythm genes in skin aging based on bioinformatics and machine learning.
Published in Aging
Skin aging is often accompanied by disruption of circadian rhythm and abnormal expression of circadian rhythm-related genes. In this study, we downloaded skin aging expression datasets from the GEO database and utilized bioinformatics and machine learning methods to explore circadian rhythm genes and pathways involved in skin aging, revealing the p...
Cholinergic centro-cingulate network in Parkinson disease and normal aging.
Published in Aging
Decreased cholinergic binding within the recently identified centro-cingulate brain network robustly has been shown to robustly correlate with the severity of cognitive impairment in Parkinson disease (PD). This network with key hubs within the cingulum, operculum and peri-central cortical regions also correlates with elements of parkinsonian motor...
PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway...
...Published in Aging
Protein L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is a repair enzyme that catalyzes the conversion of isomerized aspartic acid (iso-Asp) residues into their normal structure, thereby restoring the configuration and function of proteins. Studies have shown that PCMT1 is overexpressed in several tumors and affects patients' prognosis. ...
Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature....
Published in Aging
The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins, and glycans which are highly tissue specific and undergo pronounced changes with age. To obtain an unbiased and comprehensi...
HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immu...
Published in Aging
Human Leukocyte Antigen-DP alpha 1 (HLA-DPA1) is a critical gene in antigen-presenting cells and plays a significant role in immune regulation. The objective of this study was to comprehensively analyze the roles of HLA-DPA1 and its association with lung adenocarcinoma (LUAD). We utilized bioinformatics and conducted a meta-analysis to examine the ...
SNHG25 promotes colorectal cancer metastasis by regulating MMP2.
Published in Aging
LncRNA has been shown to play an important role in tumors, but the functions of most lncRNAs in colorectal cancer is not clear. By analyzing the transcriptome data of tumor tissues and adjacent tissues, we identified the lncRNA profiles that were abnormally expressed in colorectal cancer and selected the abnormally highly expressed lncRNA SNHG25 fo...
Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental valida...
Published in Aging
This study aimed to investigate the pharmacological effects and molecular mechanisms of Dahuang-Gancao Decoction (DHGC) on acute kidney injury (AKI). Network pharmacology was utilized to analyze the key targets of DHGC against AKI. These targets were used to construct a protein-protein interaction (PPI) network, which was analyzed using Gene Ontolo...
FAM46C-mediated tumor heterogeneity predicts extramedullary metastasis and poorer survival in multiple myeloma.
...Published in Aging
Cancers originate from a single cell according to Nowell's theory of clonal evolution. The enrichment of the most aggressive clones has been developed and the heterogeneity arises for genomic instability and environmental selection. Multiple myeloma (MM) is a multiple relapse plasma cell cancer generated from bone marrow. Although there were accumu...
