YAP: a novel target for Alzheimer's disease.
Published in Aging
miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer.
Published in Aging
FAM83D (family with sequence similarity 83, member D) is of particular interest in tumorigenesis and tumor progression. Ovarian cancer is the leading cause of cancer-related death in women all over the world. This study aims to research the association between FAM83D and ovarian cancer (OC). The gene expression data of OC and normal samples (GSE818...
VEGF-A-related genetic variants protect against Alzheimer's disease.
...Published in Aging
The Apolipoprotein E (APOE) genotype has been shown to be the strongest genetic risk factor for Alzheimer's disease (AD). Moreover, both the lipolysis-stimulated lipoprotein receptor (LSR) and the vascular endothelial growth factor A (VEGF-A) are involved in the development of AD. The aim of the study was to develop a prediction model for AD includ...
Correction for: Long non-coding RNA PVT1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes ost...
Published in Aging
piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.
Published in Aging
Previous studies found that piRNAs could participate in disease progression by regulating DNA methylation, but there are few reports on their roles in heart failure (HF). The level of piRNA-6426 in the venous blood of HF patients and volunteers was detected by RT-qPCR. Hypoxia-induced cardiomyocytes were transfected with lentiviral-mediated piRNA-6...
Correction for: The effects of psyllium husk on gut microbiota composition and function in chronically constipated women...
Published in Aging
Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma.
Published in Aging
Our previous study showed that Cyclin B2 (CCNB2) is closely related to the occurrence and progression of hepatocellular carcinoma (HCC). This study aimed to clarify the effect of CCNB2 gene silencing on tumorigenesis in nude mice and to detect the potential mechanism. The effect of CCNB2 on HCC was tested in vivo. The downstream target genes of CCN...
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery...
...Published in Aging
Aging biology is a promising and burgeoning research area that can yield dual-purpose pathways and protein targets that may impact multiple diseases, while retarding or possibly even reversing age-associated processes. One widely used approach to classify a multiplicity of mechanisms driving the aging process is the hallmarks of aging. In addition ...
Next-generation sequencing identifies HOXA6 as a novel oncogenic gene in low grade glioma.
Published in Aging
Low grade glioma is one of the most common lethal cancers in the human nervous system. Emerging evidence has demonstrated that homeobox A cluster (HOXA) gene family plays a critical role in the transcriptional regulation as well as cancer initiation and progression. However, the expression, biological functions and upstream regulatory mechanism of ...
Association between serum uric acid and α-klotho protein levels in the middle-aged population.
Published in Aging
This study investigated the association between hyperuricemia and serum klotho protein levels in a representative sample of adults in the United States. We included 11,734 adults aged 40-80 years with available data of serum klotho, uric acid, covariates related to demographics, health behavior-related variables, and medical histories. Hyperuricemi...
