Nyolczas, Noémi Dékány, Miklós Muk, Balázs Szabó, Barna
Published in
Advances in experimental medicine and biology
The use of direct acting vasodilators (the combination of hydralazine and isosorbide dinitrate -Hy+ISDN-) in heart failure with reduced ejection fraction (HFrEF) is supported by evidence, but rarely used.However, treatment with Hy+ISDN is guideline-recommended for HFrEF patients who cannot receive either angiotensin-converting enzyme inhibitors or ...
Witek, Bożena Rochon-Szmejchel, Danuta Stanisławska, Iwona Łyp, Marek Wróbel, Krzysztof Zapała, Arkadiusz Kamińska, Agnieszka Kołątaj, Adam
Published in
Advances in experimental medicine and biology
The study investigated a panel of lysosomal enzymes in the liver and kidney tissues in alloxan-induced diabetes in the mouse. The mice were divided into six experimental groups receiving 10% alloxan at a dose of 50 and 75 mg/kg over a period of four, eight, and twelve days; each group was compared with controls receiving 0.9% NaCl. The findings wer...
Kaushik, Stuti Saha, Rumpa Das, Shukla Ramachandran, V G Goel, Ashish
Published in
Advances in experimental medicine and biology
Diarrhea is a debilitating condition in HIV infected individuals and with the finding that almost 1/4 cases of diarrhea in HIV are due to microsporidia, there is a dire need to institute measures for its detection on a regular basis. Keeping this in mind the study aims to determine the burden of intestinal microsporidiosis in HIV seropositive patie...
Szwed, A John, A Goździk-Spychalska, J Czaiński, W Czerniak, W Ratajczak, J Batura-Gabryel, H
Published in
Advances in experimental medicine and biology
The purpose of the study was to evaluate the influence of nutrition and of the severity of mutation type on survival rate in cystic fibrosis (CF) patients. Data were longitudinally collected from 60 hospitalized adult CF patients, aged 18-50. The variables consisted of body mass index (BMI) ratio, Cole's BMI cut-off points, severity of mutation typ...
Singh, Rani Alex, Rani Singh, Umesh Kumar, Sushil Sengar, Gyanendra Singh Raja, T V Alyethodi, R R Kumar, Ashish Deb, Rajib
Published in
Advances in experimental medicine and biology
Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence o...
Luo, Xuerui Zhu, Fuxiang Chen, Zuojia Li, Dan Li, Bin
Published in
Advances in experimental medicine and biology
T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic changes are tightly linked to the activation and function of T cells. Given the importance of these cells in tumor progression, it is important ...
Ariga, Hiroyoshi Iguchi-Ariga, Sanae M M
Published in
Advances in experimental medicine and biology
The DJ-1 gene is an oncogene and also causative gene for a familial form of Parkinson disease. Although exits of cancer and neurodegenerative diseases, including Parkinson disease, are completely opposite, there are some common points of view between both diseases, including growth and death signaling pathways, and oxidative stresses affect the ons...
Antipova, Daria Bandopadhyay, Rina
Published in
Advances in experimental medicine and biology
In 2003, autosomal recessive loss-of-function mutations were identified in PARK7 gene that caused early-onset Parkinson's disease (PD). The PARK7 gene encodes a conserved protein termed DJ-1. DJ-1 is a ubiquitous protein, and within the brain, it is present in the nucleus and cytoplasm of both neuronal and glial cells. DJ-1 is a multifunctional pro...
Eberhard, Daniel Lammert, Eckhard
Published in
Advances in experimental medicine and biology
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, D...
Merker, Matthias Kohl, Thomas A Niemann, Stefan Supply, Philip
Published in
Advances in experimental medicine and biology
Tuberculosis (TB) is a contagious disease with a complex epidemiology. Therefore, molecular typing (genotyping) of Mycobacterium tuberculosis complex (MTBC) strains is of primary importance to effectively guide outbreak investigations, define transmission dynamics and assist global epidemiological surveillance of the disease. Large-scale genotyping...
