Gudesblatt, Mark Roman, Cortnee Singer, Barry A Schmidt, Hollie Thomas, Jessica Shankar, Sai L Lyons, Jennifer Kapadia, Shivani
Published in
Advances in therapy
Multiple sclerosis (MS), an immune-related disease, may present with neurological symptoms that come and go. Diroximel fumarate (DRF) is a next-generation oral treatment for MS, which has been shown in clinical trials to have fewer gastrointestinal side effects compared to dimethyl fumarate (DMF), another oral treatment. Patients’ perspective can s...
Müderrisoglu, A Elif Oelke, Matthias Schneider, Tim Murgas, Sandra de la Rosette, Jean J M C H Michel, Martin C
Published in
Advances in therapy
Unmet expectations are a major reason why patients with overactive bladder syndrome discontinue treatment. To enable evidence-based counselling of patients on realistic expectations, we have determined the chance that patients with overactive bladder become free of urgency, incontinence, voiding frequency, and nocturia. Two non-interventional studi...
Brittain, Dominic D'Andrea, Peter Gruen, Emilie Hosoe, Motoi Jain, Devendra Jauernig, Juergen Pethe, Abhijit Scosyrev, Emil Tanase, Ana-Maria Tillmann, Hanns-Christian
...
Published in
Advances in therapy
A novel, once-daily (o.d.), fixed-dose combination (FDC) of indacaterol acetate (IND), glycopyrronium bromide (GLY), and mometasone furoate (MF), delivered by the inhaler Breezhaler® device, is the first long-acting beta2-adrenergic agonist/long-acting muscarinic antagonist/inhaled corticosteroid (LABA/LAMA/ICS) therapy to be approved for maintenan...
Okada, Annabelle A Takahashi, Kanji Ohji, Masahito Moon, SungChul Charles Machewitz, Tobias Sasaki, Koji
Published in
Advances in therapy
To explore the efficacy and safety of intravitreal aflibercept (IVT-AFL) proactive, individualized treat-and-extend (T&E) regimens in exudative age-related macular degeneration (AMD) in the subgroup of patients with polypoidal choroidal vasculopathy (PCV) enrolled in the ALTAIR study. This was a PCV subgroup analysis of ALTAIR, a 96-week, randomize...
Schreiber, Stefan Ben-Horin, Shomron Alten, Rieke Westhovens, René Peyrin-Biroulet, Laurent Danese, Silvio Hibi, Toshifumi Takeuchi, Ken Magro, Fernando An, Yoorim
...
Published in
Advances in therapy
The coronavirus disease 2019 (COVID-19) pandemic has prompted significant changes in patient care in rheumatology and gastroenterology, with clinical guidance issued to manage ongoing therapy while minimising the risk of nosocomial infection for patients and healthcare professionals (HCPs). Subcutaneous (SC) formulations of biologics enable patient...
Yang, Xiaoyan Fan, Qian Zhang, Yue Chen, Xiaoqin Jiang, Yanglin Zou, Haohan Li, Mengdi Li, Lihua Wang, Yan
Published in
Advances in therapy
To investigate changes in refractive error in schoolchildren before and during the coronavirus disease 2019 (COVID-19) pandemic. This study included 2792 students, who underwent a 3-year follow-up from 2018 to 2020. All participants underwent yearly noncycloplegic refraction and ocular examinations. Time-related changes in sphere, cylinder, and sph...
Dalén, Johan Chitkara, Anushri Svedbom, Axel Olofsson, Tor Puenpatom, Amy Black, Christopher M Qureshi, Zaina P
Published in
Advances in therapy
A few studies have suggested that patients with inflammatory arthritis (IA) who remain persistent with subcutaneous TNF-α inhibitors (SC-TNFi) incur lower health care costs than patients who discontinue treatment, whereas data on the impact of non-persistence on indirect costs are largely lacking. Furthermore, existing estimates are based on fixed ...
Watkins, Richard R.
Published in
Advances in Therapy
The COVID-19 pandemic has drawn considerable attention to viral pneumonia from clinicians, public health authorities, and the general public. With dozens of viruses able to cause pneumonia in humans, differentiating viral from bacterial pneumonia can be very challenging in clinical practice using traditional diagnostic methods. Precision medicine i...
Jensterle, Mojca Rizzo, Manfredi Haluzík, Martin Janež, Andrej
Published in
Advances in Therapy
The approval of once daily liraglutide, 3.0 mg, and once weekly semaglutide, 2.4 mg, for chronic weight management provides a novel effective strategy against obesity. The reliable models that might predict weight reducing potential at the individual level have not been identified yet. However, the coexistence of diabetes has been consistently rela...
Krishnan, Sangeeta Sarda, Sujata Kunzweiler, Colin Wu, Melody Sundaresan, Sanjana Huynh, Lynn Duh, Mei Sheng Escalante, Carmelita P
Published in
Advances in therapy
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder characterized by anemia and debilitating fatigue. Limited evidence characterizes the association between hemoglobin, an indicator of anemia and disease activity, and patient-reported fatigue scales. This review identifies benchmarks for clinically meaningful improvements in patients...
