Wang, Yalan Chen, Qiubing Wu, Shuang Sun, Xinyu Yin, Runting Ouyang, Zhen Yin, Hao Wei, Yuan
Published in
Acta pharmaceutica Sinica. B
Alcoholic liver disease (ALD) results from continuous and heavy alcohol consumption. The current treatment strategy for ALD is based on alcohol withdrawal coupled with antioxidant drug intervention, which is a long process with poor efficacy and low patient compliance. Alcohol-induced CYP2E1 upregulation has been demonstrated as a key regulator of ...
Ci, Li-Qian Huang, Zhi-Gang Liu, Yu Liu, Zhe-Peng Wei, Gang Lu, Wei-Yue
Published in
Acta pharmaceutica Sinica. B
[This corrects the article DOI: 10.1016/j.apsb.2017.03.002.]. © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Lu, Mei Xing, Haonan Shao, Wanxuan Wu, Pengfei Fan, Yuchuan He, Huining Barth, Stefan Zheng, Aiping Liang, Xing-Jie Huang, Yuanyu
...
Published in
Acta pharmaceutica Sinica. B
Immunotherapy has revolutionized the landscape of cancer treatment. However, single immunotherapy only works well in a small subset of patients. Combined immunotherapy with antitumor synergism holds considerable potential to boost the therapeutic outcome. Nevertheless, the synergistic, additive or antagonistic antitumor effects of combined immunoth...
Cong, Wei Shen, Huaxing Liao, Xiufei Zheng, Mengjun Kong, Xianglong Wang, Zhe Chen, Si Li, Yulei Hu, Honggang Li, Xiang
...
Published in
Acta pharmaceutica Sinica. B
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells. The all-hydrocarbon peptide stapling technique has already widely adopted with great success, yielding numerous potent peptide-based molecules. Ba...
Xing, Xudong Sun, Mengru Guo, Zifan Zhao, Yongjuan Cai, Yuru Zhou, Ping Wang, Huiying Gao, Wen Li, Ping Yang, Hua
...
Published in
Acta pharmaceutica Sinica. B
The chemical complexity of traditional Chinese medicines (TCMs) makes the active and functional annotation of natural compounds challenging. Herein, we developed the TCMs-Compounds Functional Annotation platform (TCMs-CFA) for large-scale predicting active compounds with potential mechanisms from TCM complex system, without isolating and activity t...
Li, Yanan Li, Keqin Pan, Ting Xie, Qiaobo Cheng, Yuyao Wu, Xinfeng Xu, Rui Liu, Xiaohui Liu, Li Gao, Jiangming
...
Published in
Acta pharmaceutica Sinica. B
The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target for cancer treatment. However, results have often been disappointing due to crosstalk with other signals. Here, we report that IGF-1R signaling stimulates the growth of hepatocellular carcino...
Wu, Jiawei Xing, Liyun Zheng, Yaxian Yu, Yinglan Wu, Ruinan Liu, Xi Li, Lian Huang, Yuan
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Acta pharmaceutica Sinica. B
Protein corona (PC) has been identified to impede the transportation of intravenously injected nanoparticles (NPs) from blood circulation to their targeted sites. However, how intestinal PC (IPC) affects the delivery of orally administered NPs are still needed to be elucidated. Here, we found that IPC exerted "positive effect" or "negative effect" ...
Luo, Mingcui Yi, Yiwen Huang, Songqiang Dai, Shiyun Xie, Lulu Liu, Kexin Zhang, Shuai Jiang, Tao Wang, Tingting Yao, Baozhen
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Published in
Acta pharmaceutica Sinica. B
The formation of learning and memory is regulated by synaptic plasticity in hippocampal neurons. Here we explored how gestational exposure to dexamethasone, a synthetic glucocorticoid commonly used in clinical practice, has lasting effects on offspring's learning and memory. Adult offspring rats of prenatal dexamethasone exposure (PDE) displayed si...
Yang, Junjie Pan, Yue Zeng, Xiaoshan Liu, Shuwen Chen, Zhipeng Cheng, Kui
Published in
Acta pharmaceutica Sinica. B
Toll-like receptor 2 (TLR2) mediated macrophages regulate the protective immune response to infectious microorganisms, but the aberrant activation of macrophages often leads to pathological inflammation, including tissue damage. In this study, we identified antagonists of TLR2 by screening 2100 natural products and subsequently identified Taspine, ...
Liu, Huiwen Wang, Honglan Li, Qiyu Wang, Yiwei He, Ying Li, Xuejing Sun, Chunyan Ergonul, Onder Can, Füsun Pang, Zhiqing
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Published in
Acta pharmaceutica Sinica. B
Chronic inflammation is critical in the onset and progression of atherosclerosis (AS). The lipopolysaccharide (LPS) level in the circulation system is elevated in AS patients and animal models, which is correlated with the severity of AS. Inspired by the underlying mechanism that LPS could drive the polarization of macrophages toward the M1 phenoty...
