Kolibová, Sofie Dragoun Wölfel, Eva Maria Hemmatian, Haniyeh Milovanovic, Petar Mushumba, Herbert Wulff, Birgit Neidhardt, Maximilian Püschel, Klaus Failla, Antonio Virgilio Vlug, Annegreet
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Published in
Acta biomaterialia
Bone fragility is a profound complication of type 1 diabetes mellitus (T1DM), increasing patient morbidity. Within the mineralized bone matrix, osteocytes build a mechanosensitive network that orchestrates bone remodeling; thus, osteocyte viability is crucial for maintaining bone homeostasis. In human cortical bone specimens from individuals with T...
Agrafiotis, Emmanouil Mayer, Christian Grabenwöger, Martin Zimpfer, Daniel Regitnig, Peter Mächler, Heinrich Holzapfel, Gerhard A
Published in
Acta biomaterialia
The effects of thoracic endovascular repair (TEVAR) on the biomechanical properties of aortic tissue have not been adequately studied. Understanding these features is important for the management of endograft-triggered complications of a biomechanical nature. This study aims to examine how stent-graft implantation affects the elastomechanical behav...
Richter, Richard Frank Ahlfeld, Tilman Gelinsky, Michael Lode, Anja
Published in
Acta biomaterialia
Calcium phosphate cements (CPC) and mesoporous bioactive glasses (MBG) are two well studied biomaterial groups widely under investigation on their applicability to treat bone defects in orthopaedics and maxillofacial surgery. Recently the extrusion properties of CPC-MBG composites using a pasty CPC based on a hydrophobic carrier-liquid were studied...
Hatt, Luan P Armiento, Angela R Mys, Karen Thompson, Keith Hildebrand, Maria Nehrbass, Dirk Müller, Werner E G Zeiter, Stephan Eglin, David Stoddart, Martin J
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Published in
Acta biomaterialia
Understanding the optimal conditions required for bone healing can have a substantial impact to target the problem of non-unions and large bone defects. The combination of bioactive factors, regenerative progenitor cells and biomaterials to form a tissue engineered (TE) complex is a promising solution but translation to the clinic has been slow. We...
de Silva, Leanne Bernal, Paulina N Rosenberg, Ajw Malda, Jos Levato, Riccardo Gawlitta, Debby
Published in
Acta biomaterialia
The development of tissue engineering strategies for treatment of large bone defects has become increasingly relevant, given the growing demand for bone substitutes. Native bone is composed of a dense vascular network necessary for the regulation of bone development, regeneration and homeostasis. A major obstacle in fabricating living, clinically r...
Li, Ting Hou, Juedong Wang, Ling Zeng, Guanjie Wang, Zihan Yu, Liu Yang, Qiao Yin, Junfeiyang Long, Meng Chen, Lizhi
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Published in
Acta biomaterialia
Viscoelastic hydrogels can enhance 3D cell migration and proliferation due to the faster stress relaxation promoting the arrangement of the cellular microenvironment. However, most synthetic photocurable hydrogels used as bioink materials for 3D bioprinting are typically elastic. Developing a photocurable hydrogel bioink with fast stress relaxation...
Palmquist, Anders Jolic, Martina Hryha, Eduard Shah, Furqan A
Published in
Acta biomaterialia
The last decade has witnessed rapid advancements in manufacturing technologies for biomedical implants. Additive manufacturing (or 3D printing) has broken down major barriers in the way of producing complex 3D geometries. Electron beam melting (EBM) is one such 3D printing process applicable to metals and alloys. EBM offers build rates up to two or...
Mirkhalaf, Mohammad Men, Yinghui Wang, Rui No, Young Zreiqat, Hala
Published in
Acta biomaterialia
3D printed bone scaffolds have the potential to replace autografts and allografts because of advantages such as unlimited supply and the ability to tailor the scaffolds' biochemical, biological and biophysical properties. Significant progress has been made over the past decade in additive manufacturing techniques to 3D print bone grafts, but challe...
Belluomo, Ruggero Khodaei, Azin Amin Yavari, Saber
Published in
Acta biomaterialia
Bone tissue exhibits critical factors for metastatic cancer cells and represents an extremely pleasant spot for further growth of tumors. The number of metastatic bone lesions and primary tumors that arise directly from cells comprised in the bone milieu is constantly increasing. Bioceramics have recently received significant attention in bone tiss...
Yu, Xiaopeng Wang, Yufeng Zhang, Meng Ma, Hongshi Feng, Chun Zhang, Bingjun Wang, Xin Ma, Bing Yao, Qingqiang Wu, Chengtie
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Published in
Acta biomaterialia
It is of significance to construct the immunomodulatory and osteogenic microenvironment for three dimension (3D) regeneration of bone tissues. 3D scaffolds, with various chemical composition, macroporous structure and surface characteristics offer a beneficial microenvironment for bone tissue regeneration. However, there is a gap between the well-o...
