Ilie, Mirela Diana Vasiljevic, Alexandre Chanal, Marie Gadot, Nicolas Chinezu, Laura Jouanneau, Emmanuel Hennino, Ana Raverot, Gérald Bertolino, Philippe
Published in
Acta Neuropathologica Communications
Folliculostellate cells are S100B-expressing cells with numerous functions in the normal anterior pituitary. These cells have also been identified in pituitary neuroendocrine tumours (PitNETs), where their precise role remains elusive. Here, we aimed to build a refined cartography of S100B-expressing cells to characterise their interpatient and int...
Tok, S Maurin, H Delay, C Crauwels, D Manyakov, N V Van Der Elst, W Moechars, D Drinkenburg, W H I M
Published in
Acta neuropathologica communications
The two main histopathological hallmarks that characterize Alzheimer's Disease are the presence of amyloid plaques and neurofibrillary tangles. One of the current approaches to studying the consequences of amyloid pathology relies on the usage of transgenic animal models that incorporate the mutant humanized form of the amyloid precursor protein (h...
Hall, Sara Orrù, Christina D. Serrano, Geidy E. Galasko, Douglas Hughson, Andrew G. Groveman, Bradley R. Adler, Charles H. Beach, Thomas G. Caughey, Byron Hansson, Oskar
...
Published in
Acta Neuropathologica Communications
Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedis...
Yu, Dahyun Zarate, Nicole White, Angel Coates, De’jah Tsai, Wei Nanclares, Carmen Cuccu, Francesco Yue, Johnny S. Brown, Taylor G. Mansky, Rachel H.
...
Published in
Acta Neuropathologica Communications
Dromard, Yann Arango-Lievano, Margarita Borie, Amelie Dedin, Maheva Fontanaud, Pierre Torrent, Joan Garabedian, Michael J. Ginsberg, Stephen D. Jeanneteau, Freddy
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Acta Neuropathologica Communications
Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in age-related progression of Alzheimer's disease (AD). However, the GR pathways required for influencing the pathobiology of AD dementia remain unknown. To address this, we studied an early phase of AD-like progression in the well-established APP/PS1 mouse ...
Megías, Javier San-Miguel, Teresa Sánchez, Mirian Navarro, Lara Monleón, Daniel Calabuig-Fariñas, Silvia Morales, José Manuel Muñoz-Hidalgo, Lisandra Roldán, Pedro Cerdá-Nicolás, Miguel
...
Published in
Acta Neuropathologica Communications
Desmoplastic infantile astrocytoma (DIA) is rare, cystic and solid tumor of infants usually found in superficial cerebral hemispheres. Although DIA is usually benign, uncommon cases bearing malignant histological and aggressive clinical features have been described in the literature. We report a newborn patient who was diagnosed with a DIA and died...
Mey, Gabrielle M Evonuk, Kirsten S Chappell, McKenzie K Wolfe, Laura M Singh, Rupesh Batoki, Julia C Yu, Minzhong Peachey, Neal S Anand-Apte, Bela Bermel, Robert
...
Published in
Acta neuropathologica communications
Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune demyelination that exhibits CNS-infiltrating immune cells in both spinal cord white matter and optic nerve, we s...
Utagawa, Emma C. Moreno, David G. Schafernak, Kristian T. Arva, Nicoleta C. Malek-Ahmadi, Michael H. Mufson, Elliott J. Perez, Sylvia E.
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Acta Neuropathologica Communications
Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the prenatal frontal cortex (FC), a knowledge gap exists on the effects of trisomy 21 upon postnatal cortical development. Here, we examined cortical neurogenesis and differentiation in the FC supragr...
Alves de Castro, João Víctor D’Almeida Costa, Felipe
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Acta Neuropathologica Communications
Yu, Dahyun Zarate, Nicole White, Angel Coates, De’jah Tsai, Wei Nanclares, Carmen Cuccu, Francesco Yue, Johnny S. Brown, Taylor G. Mansky, Rachel H.
...
Published in
Acta Neuropathologica Communications
Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. HTT mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of the basal ganglia. Transcriptional perturbations in synaptic genes and neuroinf...
