Yang, Xin Arslan, Mehboob Liu, Xingjian Song, Haozhi Du, Mengtan Li, Yinü Zhang, Zhifang
Published in
Acta Biochimica et Biophysica Sinica
Newcastle disease virus (NDV) causes severe economic losses through severe morbidity and mortality and poses a significant threat to the global poultry industry. Significant efforts have been made to develop novel vaccines and therapeutics; however, the interaction of NDV with the host is not yet fully understood. Interferons (IFNs), an integral co...
Saremi, Kamelia Rad, Sima Kianpour Khalilzadeh, Maryam Hussaini, Jamal Majid, Nazia Abdul
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Acta Biochimica et Biophysica Sinica
Chlorine is shown to possess anti-gastric ulcer activity, since it can inactivate Helicobacter pylori , which is regarded as one of the most common risk factors for causing gastric problems. In the current study, the gastroprotective property of a novel dichloro-substituted Schiff base complex, 2, 2′- [−1, 2-cyclohexanediylbis(nitriloethylidyne)] b...
Hao, Pan Cui, Xia Liu, Jing Li, Muzi Fu, Yong Liu, Qun
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Acta biochimica et biophysica Sinica
Few information of the function of stearoyl-coenzyme A (CoA) desaturase (SCD) in apicomplaxan parasite has been obtained. In this study, we retrieved a putative fatty acyl-CoA desaturase (TGGT1_238950) by a protein alignment with Plasmodium falciparum SCD in ToxoDB. A typical Δ9-desaturase domain was revealed in this protein. The putative desaturas...
Yang, Yiyuan Zhang, Kai Chen, Linxi Li, Lanfang
Published in
Acta Biochimica et Biophysica Sinica
Zhang, Beili Wu, Jugang Cai, Yantao Luo, Meng Wang, Bing Gu, Yan
Published in
Acta Biochimica et Biophysica Sinica
Gastric cancer is one of the most common cancers worldwide and is the third leading cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological as...
Liu, Ruijie Miller, Christian D’Annibale, Christiana Vo, Kimberly Jacobs, Ashley
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Acta Biochimica et Biophysica Sinica
Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart. In both neonatal and adult cardiac myocytes, PP1β was mai...
You, Weiqiang Tan, Gewen Sheng, Nengquan Gong, Jianfeng Yan, Jun Chen, Di Zhang, Huizhen Wang, Zhigang
Published in
Acta biochimica et biophysica Sinica
Wu, Jian Jackson-Weaver, Olan Xu, Jian
Published in
Acta Biochimica et Biophysica Sinica
TGFβ superfamily includes the transforming growth factor βs (TGFβs), bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and Activin/Inhibin families of ligands. Among the 33 members of TGFβ superfamily ligands, many act on multiple types of cells within the heart, including cardiomyocytes, cardiac fibroblasts/myofibroblas...
Zhou, Muqing Jin, Zhiming Liu, Yiwen He, Yiqing Du, Yan Yang, Cuixia Wang, Yingzhi Hu, Jiajie Cui, Lian Gao, Feng
...
Published in
Acta Biochimica et Biophysica Sinica
Serum carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is dysregulated in various malignant tumors and has been associated with tumor progression. However, the expression and regulatory mechanisms of serum CEACAM1 in gastrointestinal cancer are still unclear. The expression ratio of the CEACAM1-L and CEACAM1-S isoforms has seldom...
Benatti, Paolo Belluti, Silvia Benoit Miotto Neusiedler, Julia Dolfini, Diletta Drac, Marjorie Basile, Valentina Schwob, Etienne Mantovani, Roberto Blow, J. Julian
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Published in
Acta Biochimica et Biophysica Sinica
NF-Y is a heterotrimeric transcription factor, which plays a pioneer role in the transcriptional control of promoters containing the CCAAT-box, among which genes involved in cell cycle regulation, apoptosis and DNA damage response. The knock-down of the sequence-specific subunit NF-YA triggers defects in S-phase progression, which lead to apoptotic...
