Bedarida, Tatiana Baron, Stephanie Vessieres, Emilie Vibert, Francoise Ayer, Audrey Marchiol-Fournigault, Carmen Henrion, Daniel Paul, Jean-Louis Florence Noble Golmard, Jean-Louis
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Published in
AJP Heart and Circulatory Physiology
High-protein-low-carbohydrate (HP-LC) diets have become widespread. Yet their deleterious consequences, especially on glucose metabolism and arteries, have already been underlined. Our previous study (2) has already shown glucose intolerance with major arterial dysfunction in very old mice subjected to an HP-LC diet. The hypothesis of this work was...
Egom, Emmanuel Eroume A Mohamed, Tamer M A Mamas, Mamas A Shi, Ying Liu, Wei Chirico, Debora Stringer, Sally E Ke, Yunbo Shaheen, Mohamed Wang, Tao
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Published in
American journal of physiology. Heart and circulatory physiology
We investigated whether plasma long-chain sphingoid base (LCSB) concentrations are altered by transient cardiac ischemia during percutaneous coronary intervention (PCI) in humans and examined the signaling through the sphingosine-1-phosphate (S1P) cascade as a mechanism underlying the S1P cardioprotective effect in cardiac myocytes. Venous samples ...
Bishop, Martin J Plank, Gernot Burton, Rebecca A B Schneider, Jürgen E Gavaghan, David J Grau, Vicente Kohl, Peter
Published in
American journal of physiology. Heart and circulatory physiology
Recent advances in magnetic resonance (MR) imaging technology have unveiled a wealth of information regarding cardiac histoanatomical complexity. However, methods to faithfully translate this level of fine-scale structural detail into computational whole ventricular models are still in their infancy, and, thus, the relevance of this additional comp...
Mukhopadhyay, Partha Rajesh, Mohanraj Bátkai, Sándor Kashiwaya, Yoshihiro Haskó, György Liaudet, Lucas Szabó, Csaba Pacher, Pál
Published in
American journal of physiology. Heart and circulatory physiology
Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in DOX-induced cardiotoxicity, but its mechanisms are elusive. Here, we explore the role of superoxide, nitric oxide (NO), and peroxynitrite in DOX-induced cell death using both in vivo and in vi...
Pope, Adèle J Sands, Gregory B Smaill, Bruce H LeGrice, Ian J
Published in
American journal of physiology. Heart and circulatory physiology
There is strong support for the view that the ventricular myocardium has a laminar organization in which myocytes are grouped into branching layers separated by cleavage planes. However, understanding of the extent and functional implications of this architecture has been limited by the lack of a systematic three-dimensional description of the orga...
Crabtree, Mark J Smith, Caroline L Lam, George Goligorsky, Michael S Gross, Steven S
Published in
American journal of physiology. Heart and circulatory physiology
5,6,7,8-Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthases (NOSs). Oxidation of BH(4), in the setting of diabetes and other chronic vasoinflammatory conditions, can cause cofactor insufficiency and uncoupling of endothelial NOS (eNOS), manifest by a switch from nitric oxide (NO) to superoxide production. Here we tested t...
