Timothy Ray Brown's Continuing Activism Toward Curing HIV.
Published in AIDS research and human retroviruses
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High Prevalence of Drug Resistance Mutations Among Patients Failing First-Line Antiretroviral Therapy and Predictors of ...
Published in AIDS research and human retroviruses
Universal antiretroviral treatment with sustained viral suppression benefits patients and reduces HIV transmission. Effectiveness of therapy may be limited by antiretroviral drug resistance. Information on the resistance profile at treatment failure and its impact on antiretroviral drugs may subsidize subsequent treatment strategies. Partial pol se...
Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Va...
...Published in AIDS research and human retroviruses
We assessed the safety and immunogenicity of HIV-DNA priming using Zetajet™, a needle-free device intradermally followed by intramuscular HIV-MVA boosts, in 24 healthy Mozambicans. Volunteers were randomized to receive three immunizations of 600 μg (n = 10; 2 × 0.1 ml) or 1,200 μg (n = 10; 2 × 0.2 ml) of HIV-DNA (3 mg/ml), followed by two boosts of...
Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Admi...
...Published in AIDS research and human retroviruses
Alcohol use disorder (AUD) is a frequent comorbidity among people living with HIV/AIDS (PLWHA). Alcohol consumption is a significant predictor of nonadherence to antiretroviral therapy (ART), as well as worsening immunological and virological indicators among PLWHA. Clinical studies indicate that higher viral loads increase sensitivity to alcohol i...
A Cohort Approach to Real Time Detection of Acute HIV infections among People who Inject Drugs in St. Petersburg, Russia...
Published in AIDS research and human retroviruses
This was the first study to detect AHI using a cohort approach. The approach proved to be feasible: recruitment, retention, AHI detection and virological endpoints were successfully reached. A cost analysis in a real world setting would be required to determine if this strategy could be brought to scale. The study revealed continued high HIV incide...
HARNESSING NOVEL IMAGING APPROACHES TO GUIDE HIV PREVENTION AND CURE DISCOVERIES - A NATIONAL INSTITUTES OF HEALTH AND G...
Published in AIDS research and human retroviruses
Advances in imaging technologies have greatly increased our understanding of cellular and molecular interactions in humans and their corresponding animal models of infectious diseases. In the HIV/SIV field, imaging has provided key insights into mucosal viral transmission, local and systemic virus spread, host-virus dynamics, and chronic inflammati...
Recruitment of underrepresented minority researchers into HIV prevention research: The HIV Prevention Trials Network (HP...
Published in AIDS research and human retroviruses
Most US investigators in the HIV Prevention Trials Network (HPTN) have been of majority race/ethnicity and sexual orientation. Research participants, in contrast, have been disproportionately from racial/ethnic minorities and men who have sex with men (MSM), reflecting the US epidemic. We initiated and subsequently evaluated the HPTN Scholars Progr...
Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
Published in AIDS research and human retroviruses
A successful HIV cure strategy may require reversing HIV latency to purge hidden viral reservoirs or enhancing HIV latency to permanently silence HIV transcription. Epigenetic modifying agents show promise as antilatency therapeutics in vitro and ex vivo, but also affect other steps in the viral life cycle. In this review, we summarize what we know...
Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report ...
...Published in AIDS research and human retroviruses
A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently exist on the status of ART drug-resistance-associated mutations (DRMs). In this study, we aim at analyzing DRM prof...
Cytomegalovirus and HIV Persistence: Pouring Gas on the Fire.
Published in AIDS research and human retroviruses
The inherent stability of a small population of T cells that are latently infected with HIV despite antiretroviral therapy (ART) remains a stubborn obstacle to an HIV cure. By exploiting the memory compartment of our immune system, HIV maintains persistence in a small subset of quiescent cells with varying phenotypes, thus evading immune surveillan...
