Fuge, Terefe Gone Tsourtos, George Miller, Emma R.
Published in
AIDS Research and Therapy
BackgroundMaintaining optimal adherence and viral suppression in people living with HIV (PLWH) is essential to ensure both preventative and therapeutic benefits of antiretroviral therapy (ART). Prisoners bear a particularly high burden of HIV infection and are highly likely to transmit to others during and after incarceration. However, the level of...
Hall, Nolwenn Allavena, Clotilde Katlama, Christine Jobert, Alexandra Molina, Jean-Michel Cua, Eric Bani-Sadr, Firouzé Hocqueloux, Laurent Duvivier, Claudine Merrien, Dominique
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Published in
AIDS Research and Therapy
BackgroundRaltegravir (RAL) has favorable tolerability and safety profile, with few and manageable drug interactions. The use of RAL 1200 mg once daily (qd) for first-line therapy is well established. We assessed efficacy and safety of RAL 1200 mg qd, as part of triple combined antiretroviral therapy (cART), for maintenance strategy.MethodsThe QDIS...
Danwang, Celestin Noubiap, Jean Jacques Robert, Annie Yombi, Jean Cyr
Published in
AIDS Research and Therapy
BackgroundData on the association of human immunodeficiency virus (HIV) infection with adverse outcomes in patients with COVID-19 are conflicting. This systematic review and meta-analysis aimed to summarize the available information on the risk of hospitalization, severe disease, and death attributable to HIV in patients with COVID-19.MethodsPubMed...
de Almeida Baptista, Marcella Vassão da Silva, Laís Teodoro Samer, Sadia Oshiro, Telma Miyuki Shytaj, Iart Luca Giron, Leila B. Pena, Nathalia Mantovani Cruz, Nicolly Gosuen, Gisele Cristina Ferreira, Paulo Roberto Abrão
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Published in
AIDS Research and Therapy
BackgroundWe developed a personalized Monocyte-Derived Dendritic-cell Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific T-cell responses.MethodsPBMCs were obtained from 10 HIV+ individuals enrolled in trial NCT02961829. Monocytes were differentiated into DCs using IFN-α and GM-CSF. After...
Dear, Nicole Esber, Allahna Iroezindu, Michael Bahemana, Emmanuel Kibuuka, Hannah Maswai, Jonah Owuoth, John Polyak, Christina S. Ake, Julie A. Crowell, Trevor A.
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Published in
AIDS Research and Therapy
BackgroundRetention in clinical care is important for people living with HIV (PLWH). Evidence suggests that missed clinic visits are associated with interruptions in antiretroviral therapy (ART), lower CD4 counts, virologic failure, and overlooked coinfections. We identified factors associated with missed routine clinic visits in the African Cohort...
Ness, Tara E. Agrawal, Vedika Guffey, Danielle Small, Amanda Simelane, Tandzile Dlamini, Sandile Petrus, Jaime Lukhele, Bhekumusa
Published in
AIDS Research and Therapy
BackgroundIn 2018, approximately 1.6 million adolescents (aged 10–19) were living with HIV worldwide, with the highest HIV prevalence found in Eswatini. Adolescents and young adults living with HIV are a vulnerable population due to unique psychosocial challenges that come with having a stigmatizing disease. This group struggles more than other age...
Yang, Rongrong Gui, Xien Ke, Hengning Xiong, Yong Gao, Shicheng
Published in
AIDS Research and Therapy
BackgroundLiver fibrosis is common in individuals with HIV/HBV co-infection, but whether cART could reverses liver fibrosis is unclear.MethodsThis was a retrospective observational study. Binary logistic regression was used to assess predictors of liver fibrosis in individuals with HIV/HBV co-infection. Comparison of FIB-4 scores before and after c...
Zenebe, Yosef Akele, Baye W/Selassie, Mulugeta Necho, Mogesie
Published in
AIDS Research and Therapy
BackgroundEthiopia, being in the Sub Saharan region of Africa, is one of the countries with a substantial burden of HIV infection. Because of the high burden of HIV and poor health care settings, HAND is prevalent as demonstrated in various cross-sectional studies. However, no review has been conducted to report the consolidated magnitude of HAND a...
Mabaso, Musawenkosi Maseko, Goitseone Sewpaul, Ronel Naidoo, Inbarani Jooste, Sean Takatshana, Sinovuyo Reddy, Tarylee Zuma, Khangelani Zungu, Nompumelelo
Published in
AIDS Research and Therapy
BackgroundAdolescents are at increased risk of HIV infection compared to other age groups. There is an urgent need for strategic information that will inform programmes to reduce risk and vulnerability to HIV and reverse the pattern of increasing HIV infection as they transition to adulthood. This paper analysed trends and factors associated with H...
Sun, Chengqing Li, Jianjun Liu, Xiaoyan Zhang, Zhi Qiu, Tao Hu, Haiyang Wang, You Fu, Gengfeng
Published in
AIDS Research and Therapy
BackgroundLate presentation to HIV/AIDS care presents serious health concerns, like increased transmission and high healthcare costs, increased mortality, early development of opportunistic infection, increased risk of antiretroviral therapy drug resistance. Despite the effort to contain the HIV/AIDS epidemic, LP has remained an impediment to indiv...
