Kebede, Kindu
Published in
AIDS Research and Therapy
BackgroundHuman immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body’s immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health problems in Sub-Saharan Africa including Ethiopia. The main objective of this study to identify the determinants of CD4 cell count among...
Buck, W. Chris Nguyen, Hanh Siapka, Mariana Basu, Lopa Greenberg Cowan, Jessica De Deus, Maria Inês Gleason, Megan Ferreira, Ferreira Xavier, Carla Jose, Benedita
...
Published in
AIDS Research and Therapy
BackgroundPediatric tuberculosis (TB), human immunodeficiency virus (HIV), and TB-HIV co-infection are health problems with evidence-based diagnostic and treatment algorithms that can reduce morbidity and mortality. Implementation and operational barriers affect adherence to guidelines in many resource-constrained settings, negatively affecting pat...
Korten, Volkan Gökengin, Deniz Eren, Gülhan Yıldırmak, Taner Gencer, Serap Eraksoy, Haluk Inan, Dilara Kaptan, Figen Dokuzoğuz, Başak Karaoğlan, Ilkay
...
Published in
AIDS Research and Therapy
BackgroundThere is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART before and after the availability of better tolerated and less complex regimens by comparing the frequency, reasons and association...
Bistoquet, Marie Makinson, Alain Tribout, Vincent Perrollaz, Cyril Bourrel, Gérard Reynes, Jacques Oude Engberink, Agnès
Published in
AIDS Research and Therapy
BackgroundPre-exposure prophylaxis (PrEP) for HIV is instrumental in the prevention of HIV for HIV-uninfected persons, by drastically reducing the risk of acquisition in the case of high-risk exposures. Despite its demonstrated efficacy, it remained under-prescribed in France until 2018. The principal aim of this study was to understand the motivat...
Bessong, Pascal O. Matume, Nontokozo D. Tebit, Denis M.
Published in
AIDS Research and Therapy
BackgroundSouth Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016. Barriers to sustained viral suppression may include drug resistance in the pre-treated population, non-adherence, acquired resistance; pharmacokinetics and pharmacodynamics, and concurrent use of a...
Pour, Mohammad James, Linda Singh, Kamlendra Mampunza, Samuel Baer, Franklin Scott, JoAnna Berg, Michael G. Rodgers, Mary A. Cloherty, Gavin A. Hackett Jr, John
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Published in
AIDS Research and Therapy
BackgroundDiagnosis of people living with HIV (PLHIV) is the first step toward achieving the new Fast Track Strategy to end AIDS by 2030: 95-95-95. However, reaching PLHIV is especially difficult in resource-limited settings such as the Democratic Republic of Congo (DRC), where reliable prevalence data is lacking. This study evaluated the prevalenc...
Bahemana, Emmanuel Esber, Allahna Dear, Nicole Ganesan, Kavitha Parikh, Ajay Reed, Domonique Maganga, Lucas Khamadi, Samoel Mizinduko, Mucho Lwilla, Anange
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Published in
AIDS Research and Therapy
IntroductionWith increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults aged
Lau, Jillian S. Y. Smith, Miranda Z. Allan, Brent Martinez, Cipriano Power, Jennifer Lewin, Sharon R. McMahon, James H.
Published in
AIDS Research and Therapy
BackgroundAnalytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the acceptability of ATI amongst people living with HIV (PLHIV) and their HIV healthcare providers (HHP) is limited.MethodsTwo online surveys ...
Ndembi, Nicaise Murtala-Ibrahim, Fati Tola, Monday Jumare, Jibreel Aliyu, Ahmad Alabi, Peter Mensah, Charles Abimiku, Alash’le Quiñones-Mateu, Miguel E. Crowell, Trevor A.
...
Published in
AIDS Research and Therapy
BackgroundA substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment failure informs patient monitoring practices and distribution of limited resources for second-line regimens. We determined predictors ...
García, Juan Ignacio Meléndez, Johanna Álvarez, Rosa Mejía-Chew, Carlos Kelley, Holden V. Sidiki, Sabeen Castillo, Alejandra Mazariegos, Claudia López-Téllez, Cesar Forno, Diana
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Published in
AIDS Research and Therapy
BackgroundImproved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppressed people living with HIV (PLWH) are needed to decrease morbidity and mortality outcomes. The aim of the study is to evaluate the performance of the lipoarabinomannan antigen test (LAM-test) with and without α-mannosidase pre-treated urine in a cohort o...
