Karunaianantham, Ramesh Nesa Kumar, Manohar Gopalan, Bindu Haribabu, Hemalatha Hanna, Luke Elizabeth Sanjeeva, G N Reddy, Devarajulu Shet, Anita Swaminathan, Soumya Padmapriyadarsini, Chandrasekaran
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Published in
AIDS research and human retroviruses
HIV-1 pol gene sequences were analyzed from 77 HIV-1 positive children infected perinatally and exhibiting virological failure (VF). Viral subtyping, phylogenetic analysis, and genotypic drug resistance analysis were carried out on samples collected before start of anti retroviral treatment (ART) (baseline, BL), and at 12 months post-ART initiation...
McLigeyo, Angela Wekesa, Paul Owuor, Kevin Mwangi, Jonathan Isavwa, Linda Mutisya, Immaculate
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AIDS research and human retroviruses
Expanded access to HIV treatment services has improved outcomes for children and adolescents living with HIV in Kenya. Minimal data are available on these outcomes. We describe temporal trends in outcomes for children and adolescents initiating antiretroviral therapy (ART) from 2004 to 2014 at sites supported by Centre for Health Solutions-Kenya, i...
Laher, Fatima Richardson, Simone I Smith, Philip Sullivan, Patrick S Abrahams, Andrea G Asowata, Osaretin E Bitangumutwenzi, Patrick Dabee, Smritee Dollah, Annabell Fernandez, Natalia
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Published in
AIDS research and human retroviruses
The HIV Research for Prevention (HIVR4P) conference catalyzes knowledge sharing on biomedical HIV prevention interventions such as HIV vaccines, antibody infusions, pre-exposure prophylaxis, and microbicides in totality-from the molecular details and delivery formulations to the behavioral, social, and structural underpinnings. HIVR4P // Virtual wa...
Fuller, Deborah H. O'Connor, Megan A.
Published in
AIDS Research and Human Retroviruses
Burns, Charles M. Borges, Monica Frye, Justin Keicher, Kathryn Elliott, Scotty Schwartz, Sheila Shipp, Kenneth Okeke, Nwora Lance McKellar, Mehri S.
Published in
AIDS Research and Human Retroviruses
HIV pre-exposure prophylaxis (PrEP) is poorly utilized in the southern United States. We examined PrEP retention in care and sexually transmitted infections (STIs) through a retrospective review of the Duke University PrEP Clinic from January 1, 2015 to October 15, 2019. We evaluated short-term (3 months), long-term (additional 8–12 months), and lo...
Card, Catherine M. Abrenica, Bernard McKinnon, Lyle R. Ball, Terry Blake Su, Ruey-Chyi
Published in
AIDS Research and Human Retroviruses
Resting CD4+ T cells are primary targets of early HIV infection events in vivo , but do not readily support HIV replication in vitro . This barrier to infection can be overcome by exposing resting CD4+ T cells to endothelial cells (ECs). ECs line blood vessels and direct T cell trafficking into inflamed tissues. Cell trafficking pathways have been ...
Beckwith, Curt G Min, Sugi Manne, Akarsh Novitsky, Vladimir Howison, Mark Liu, Tao Kuo, Irene Kurth, Ann Bazerman, Lauri Agopian, Anya
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Published in
AIDS research and human retroviruses
Justice-involved (JI) populations bear a disproportionate burden of HIV infection and are at risk of poor treatment outcomes. Drug resistance prevalence and emergence, and phylogenetic inference of transmission networks, understudied in vulnerable JI populations, can inform care and prevention interventions, particularly around the critical communi...
Chawana, Tariro Nhachi, Charles Nathoo, Kusum Ngara, Bernard Okochi, Hideaki Louie, Alexander Kuncze, Karen Katzenstein, David Metcalfe, John Gandhi, Monica
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Published in
AIDS research and human retroviruses
Objective methods of measuring antiretroviral adherence are limited. We assessed the relationship between tenofovir disoproxil fumarate (TDF) hair concentrations, self-reported adherence, and virological outcomes in HIV-infected adolescents in Harare, Zimbabwe. HIV-infected adolescents on atazanavir/ritonavir-based second-line treatment for >6 mont...
Bailey, Alexander J Rhee, Soo-Yon Shafer, Robert W
Published in
AIDS research and human retroviruses
There has been no systematic review of the prevalence of transmitted integrase strand transfer inhibitor (INSTI) resistance. We systematically searched the English-language PubMed database and GenBank to identify studies published since 2010 reporting 50 or more INSTI-naive HIV-1-infected adults undergoing integrase genotyping. We extracted data re...
Devanathan, Aaron S Kashuba, Angela D M
Published in
AIDS research and human retroviruses
The persistence of HIV in the spleen, despite combination antiretroviral therapy, is not well understood. Sustained immune dysregulation and delayed immune recovery, in addition to immune cell exhaustion, may contribute to persistence of infection in the spleen. Eliminating HIV from this secondary lymphoid organ will require a thorough understandin...
