Siddiqui, Mohammed Moore, T J Long, Dustin M Burkholder, Greer A Willig, Amanda Wyatt, Christina Heath, Sonya Muntner, Paul Overton, Edgar Turner
Published in
AIDS research and human retroviruses
Hypertension (HTN) is a common comorbidity among people with HIV and associated with an increased risk for atherosclerotic cardiovascular disease and chronic kidney disease. The relationship of antiretroviral therapy (ART) initiation to incident HTN remains a clinical question. We determined HTN incidence at 48 weeks of follow-up among ART-naive pa...
Ferguson, Natasha Cogswell, Andrew Barker, Edward
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AIDS research and human retroviruses
HIV/SIV (simian immunodeficiency virus) infection leads to a loss of CD4+ T helper (Th) cells in number and function that begins during the acute phase and persists through the chronic phase of infection. In particular, there is a drastic decrease of Th17 and Th22 cells in the HIV/SIV-infected gastrointestinal (GI) tract as a source of interleukin ...
Boateng, Anthony Twumasi Abaidoo-Myles, Araba Bonney, Evelyn Yayra Kyei, George B
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AIDS research and human retroviruses
HIV remains incurable due to the persistence of a latent viral reservoir found in HIV-infected cells, primarily resting memory CD4+ T cells. Depletion of this reservoir may be the only way to end this deadly epidemic. In latency, the integrated proviral DNA of HIV is transcriptionally silenced partly due to the activity of histone deacetylases (HDA...
Malama, Kalonde Logie, Carmen H Narasimhan, Manjulaa Ouedraogo, Léopold Asmani, Chilanga Elamin, Hafya van de Merwe, L Leigh-Ann Hopkins, Jonathan Bukusi, Elizabeth Anne
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AIDS research and human retroviruses
The high burden of HIV in sub-Saharan Africa places significant demands on health care services. Interventions such as HIV self-testing, and pre- and post-exposure prophylaxis (PrEP and PEP) could empower individuals to determine their HIV status and prevent HIV acquisition. In 2018, the World Health Organization disseminated an online, anonymous, ...
Lessard, David Dubé, Karine Bilodeau, Martin Keeler, Patrick Margolese, Shari Rosenes, Ron Sinyavskaya, Liliya Durand, Madeleine Benko, Erika Kovacs, Colin
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AIDS research and human retroviruses
HIV cure research requires interrogating latent HIV reservoirs in deep tissues, which necessitates autopsies to avoid risks to participants. An HIV autopsy biobank would facilitate this research, but such research raises ethical issues and requires participant engagement. This study explores the willingness to participate in HIV cure research at th...
Shrestha, Isha Ming, Kristin Jimenez, Veronica Wendelborn, James Vazquez, Alexander Steward, Wayne Scott, Hyman Saberi, Parya
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AIDS research and human retroviruses
HIV pre-exposure prophylaxis (PrEP) has shown high efficacy and effectiveness for HIV prevention; however, many individuals with PrEP indications are not receiving PrEP. PrEP Coordinators work closely with patients and health care providers to increase PrEP access, and they provide unique insights into the inner workings of PrEP care and service de...
Saberi, Parya Campbell, Chadwick K Sauceda, John A Ndukwe, Samuel Dubé, Karine
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AIDS research and human retroviruses
In the United States, young adults have the highest rates of new HIV infections, and are less likely to be aware of their infection, be engaged in care, or achieve HIV viral suppression. As biomedical HIV research increasingly focuses on achieving long-term suppression without antiretroviral therapy (ART) and finding an HIV cure, little is known ab...
Roberts, Carly Creamer, Emma Boone, Cheriko A Young, A Toni Magnus, Manya
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AIDS research and human retroviruses
HIV is experienced across diverse populations, with gender and racial/ethnic minority populations bearing a significant proportion of disease. With National Institutes of Health (NIH) placing a priority on the enrollment of women and racial/ethnic minorities into studies, it is important to understand the diversity of participants in research. We s...
Rubin, Leah H Neijna, Ava G Shi, Qiuhu Hoover, Donald R Tamraz, Bani Anastos, Kathryn Edmonds, Andrew Fischl, Margaret A Gustafson, Deborah Maki, Pauline M
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AIDS research and human retroviruses
The number of people with HIV (PWH) experiencing age-associated comorbidities including those treated with medications and cognitive impairment is increasing. We examined associations between polypharmacy and cognition in older women with HIV (WWH) given their vulnerability to this comorbidity. Cross-sectional analysis capitalizing on Women's Inter...
Spence, Amanda Blair Liu, Chenglong Rubin, Leah Aouizerat, Bradley Vance, David Eugene Bolivar, Hector Lahiri, Cecile Delille Adimora, Adaora A Weber, Kathleen Gustafson, Deborah
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AIDS research and human retroviruses
Neurologic complications of the human immunodeficiency virus (HIV) are common in treated individuals, and toxicity of certain antiretroviral therapies (ART) may contribute to cognitive impairment. We investigated exposures to specific ART and cognition among women living with HIV (WLWH). Virologically suppressed (viral load
