Okhai, Hajra Vivancos-Gallego, María Jesús Hill, Teresa Sabin, Caroline A.
Published in
AIDS Research and Human Retroviruses
We identify factors associated with the normalization of the CD4+:CD8+ T cell ratio among UK Collaborative HIV Cohort study participants, and describe the association of the CD4+ and CD8+ T cell counts and the CD4+:CD8+ T cell ratio, with the risk of new AIDS events among individuals who achieve a suppressed viral load. Participants initiating comb...
McManus, Kathleen A. Killelea, Amy Honeycutt, Ethan An, Zixiao Keim-Malpass, Jessica
Published in
AIDS Research and Human Retroviruses
Insurance enrollment is complex for people living with HIV (PLWH) and people at increased risk for HIV, in part, owing to needing to ensure access to adequate provider networks and appropriate formularies. Insurance for PLWH facilitates access to HIV care/treatment and, ultimately, viral suppression, which has the individual benefit of longevity an...
Nicol, Melanie R. Cottrell, Mackenzie L. Corbett, Amanda H. Chinula, Lameck Tegha, Gerald Stanczyk, Frank Z. Hurst, Stacey Kourtis, Athena P. Tang, Jennifer H.
Published in
AIDS Research and Human Retroviruses
Overlap in metabolism pathways of endogenous female sex hormones and antiretroviral drugs may lead to altered exposure to these compounds. In a family planning clinic in Lilongwe, Malawi, blood, blood cell, and cervicovaginal fluid (CVF) samples from seventy-three HIV positive Malawian women taken in follicular and luteal menstrual phases were asse...
Junqueira, Dennis Maletich Wilkinson, Eduan Vallari, Ana Deng, Xianding Achari, Asmeeta Yu, Guixia McArthur, Carole Kaptue, Lazare Mbanya, Dora Chiu, Charles
...
Published in
AIDS Research and Human Retroviruses
Although the first HIV circulating recombinant form (CRF01_AE) is the predominant strain in many Asian countries, it is uncommonly found in the Congo Basin from where it first originated. To fill the gap in the evolutionary history of this important strain, we sequenced near complete genomes from HIV samples with subgenomic CRF01_AE regions collect...
Neil, Stuart J.D. Campbell, Edward M.
Published in
AIDS Research and Human Retroviruses
One cannot spend >5 min on social media at the moment without finding a link to some conspiracy theory or other regarding the origin of SARS-CoV2, the coronavirus responsible for the COVID-19 pandemic. From the virus being deliberately released as a bioweapon to pharmaceutical companies blocking the trials of natural remedies to boost their dangero...
Saito, Akatsuki Sultana, Tahmina Ode, Hirotaka Nohata, Kyotaro Samune, Yoshihiro Nakayama, Emi E. Iwatani, Yasumasa Shioda, Tatsuo
Published in
AIDS Research and Human Retroviruses
Binding of HIV-1 capsid (CA) to cleavage and polyadenylation specificity factor 6 (CPSF6) is hypothesized to provide a significant fitness advantage to in vivo viral replication, explaining why CA-CPSF6 interactions are strictly conserved in primate lentiviruses. We recently identified a Q4R mutation in CA after propagation of an interferon (IFN)-β...
Kaplan, Rachel L. El Khoury, Cynthia Wehbe, Sara Lize, Norma Mokhbat, Jacques
Published in
AIDS Research and Human Retroviruses
Transgender women are 49 times more likely to become HIV positive than all adults worldwide. Data were unavailable for trans women's sexual and mental health in the Middle East and North Africa until 2015–2016, when HIV prevalence (10%) and suicide attempt (46%) rates were established in Lebanon. Because of the lack of evidence-based interventions ...
Hapgood, Janet P.
Published in
AIDS Research and Human Retroviruses
Intramuscular depo-medroxyprogesterone acetate (DMPA-IM) is the most widely used hormonal contraceptive in sub-Saharan Africa. Previous meta-analyses of observational studies found a significant 40%–50% increased risk associated with DMPA-IM use, relative to no contraception or infrequent condom use. This raised substantial concerns, although these...
Boffito, Marta Waters, Laura Cahn, Pedro Paredes, Roger Koteff, Justin Van Wyk, Jean Vincent, Tia Demarest, James Adkison, Kimberly Quercia, Romina
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Published in
AIDS research and human retroviruses
In HIV-1-infected patients, virological failure can occur as a consequence of the mutations that accumulate in the viral genome that allow replication to continue in the presence of antiretrovirals (ARVs). The development of treatment-emergent resistance to an ARV can limit a patient's options for future therapy, prompting the need for ARV regimens...
Wu, Guohui Zhou, Chao Zhang, Xiangjun Zhang, Wei Lu, Rongrong Ouyang, Lin Xing, Hui Shao, Yiming Ruan, Yuhua Qian, Han-Zhu
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Published in
AIDS Research and Human Retroviruses
Older people living with HIV (PLWH) may have delayed diagnosis and access to care and therefore have poorer disease outcomes. Little is known about HIV care and disease outcomes among older PLWH in China. This retrospective cohort study used data from all adult HIV/AIDS cases during 1988–2017 in Chongqing, China from two national databases. We comp...
