Poudyal, Deepak Yang, Jun Chen, Qian Goswami, Suranjana Adelsberger, Joseph W Das, Sudipto Herman, Andrew Hornung, Ronald L Andresson, Thorkell Imamichi, Tomozumi
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Published in
AIDS (London, England)
IL-27 is known as an antiviral cytokine that inhibits HIV, hepatitis C virus, and other viruses. We have previously demonstrated that, IL-27 posttreatment after HIV-infection inhibits viral replication in primary CD4 T cells. Here, we evaluated the anti-HIV effect of IL-27 pretreatment in CD4 T cells from healthy donors prior to HIV infection with ...
Kim-Chang, Julie J Donovan, Kevin Loop, Matthew Shane Hong, Suzi Fischer, Bernard Venturi, Guglielmo Garvie, Patricia A Kohn, Jordan Rendina, H Jonathon Woods, Steven P
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Published in
AIDS (London, England)
HIV-associated neurocognitive disorders persist despite early antiretroviral therapy (ART) and optimal viral suppression. We examined the relationship between immunopathogenesis driven by various pathways of immune activation and discrete neurocognitive performance domains in youth with HIV (YWH). Observational cross-sectional study METHODS:: YWH, ...
Nelson, Julie A E de Paris, Kristina Ramirez, Catalina Edmonds, Andrew Mollan, Katie R Bay, Camden P Compliment, Kara Herold, Betsy C Anastos, Kathryn Minkoff, Howard
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Published in
AIDS (London, England)
Determine the frequency of genital HIV-1 shedding in a large cohort of women on long-term suppressive antiretroviral therapy (ART) and its association with mucosal inflammation. We measured levels of HIV-1 RNA and inflammation biomarkers in cervicovaginal lavage (CVL) from HIV-seropositive women enrolled in the Women's Interagency HIV Study (WIHS)....
Thin, Kyaw Frederix, Koen McCracken, Stephen Letsie, Mosilinyane Low, Andrea Patel, Hetal Parekh, Bharat Motsoane, Tsietso Ahmed, Nahima Justman, Jessica
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Published in
AIDS (London, England)
The Lesotho Population-based HIV Impact Assessment (LePHIA) survey was conducted nationally and designed to measure HIV prevalence, incidence, and viral load suppression (VLS). A nationally representative sample of 9,403 eligible households was surveyed between November 2016 and May 2017; analyses account for study design. Consenting participants p...
Murnane, Pamela M Bacchetti, Peter Currier, Judith S Brummel, Sean Okochi, Hideaki Phung, Nhi Louie, Alexander Kuncze, Karen Hoffman, Risa M Nematadzira, Teacler
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Published in
AIDS (London, England)
Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. In addition, we examined the association between hair TFV concentrations and virologic ...
Remien, Robert H Stirratt, Michael J Nguyen, Nadia Robbins, Reuben N Pala, Andrea N Mellins, Claude A
Published in
AIDS (London, England)
: Tremendous biomedical advancements in HIV prevention and treatment have led to aspirational efforts to end the HIV epidemic. However, this goal will not be achieved without addressing the significant mental health and substance use problems among people living with HIV (PLWH) and people vulnerable to acquiring HIV. These problems exacerbate the m...
Kim, Andrea A Behel, Stephanie Northbrook, Sanny Parekh, Bharat S
Published in
AIDS (London, England)
Wilson, Kate S Mugo, Cyrus Moraa, Hellen Onyango, Alvin Nduati, Margaret Inwani, Irene Bukusi, David Slyker, Jennifer Guthrie, Brandon L Richardson, Barbra A
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Published in
AIDS (London, England)
Adolescents and young adults (AYA) have poorer retention, viral suppression, and survival than other age groups. We evaluated correlates of initial AYA engagement in HIV care at facilities participating in a randomized trial in Kenya. Retrospective cohort study. Electronic medical records from AYA ages 10-24 attending 24 HIV care facilities in Keny...
Buckey, Jay C Fellows, Abigail M Magohe, Albert Maro, Isaac Gui, Jiang Clavier, Odile Massawe, Enica Moshi, Ndeserua
Published in
AIDS (London, England)
Evidence suggests damage to brain auditory pathways, rather than inner ear damage, underlies the hearing difficulties HIV+ individuals report. But, antiretroviral therapy (ART) may affect the hearing system and also lead to hearing complaints. Longitudinal study of HIV+ and HIV- individuals in Dar es Salaam Tanzania. A subset of this cohort started...
Siedner, Mark J Bwana, Mwebesa Bosco Asiimwe, Stephen Musinguzi, Nicholas Castillo-Mancilla, Jose Amanyire, Gideon Tracy, Russell P Bangsberg, David R Orrell, Catherine Haberer, Jessica E
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Published in
AIDS (London, England)
To determine the utility of biomarkers of immune activation, systemic inflammation, and coagulopathy prior to antiretroviral therapy to predict mortality during the first year of antiretroviral therapy (ART) in sub-Saharan Africa DESIGN:: Prospective, observational cohort METHODS:: We measured soluble CD14, interleukin-6, and D-dimer in non-pregnan...
