Published in ACS sensors
Poor adherence to pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) can lead to human immunodeficiency virus (HIV) acquisition and emergence of drug resistant infections, respectively. Measurement of antiviral drug levels provides objective adherence information that may help prevent adverse health outcomes. Gold standard drug-level ...
Published in ACS sensors
Quantum dot-DNA oligonucleotide (QD-DNA) conjugates have been used in many fields such as nucleic acid bioassays, intracellular probes, and drug delivery systems. A typical solid-phase method that achieves rapid loading of oligonucleotides on surfaces of QDs involves a two-step reaction and is performed in a batch-based approach. In contrast, dropl...
Published in ACS sensors
Molecularly imprinted polymers (MIPs) receive extensive interest, owing to their structure predictability, recognition specificity, and application universality as well as robustness, simplicity, and inexpensiveness. Surface-enhanced Raman scattering (SERS) is regarded as an ideal optical detection candidate for its unique features of fingerprint r...
Published in ACS sensors
Apoptosis plays crucial roles during development and in disease conditions. While there are some methods to detect apoptosis in vitro, most of them are end-point assays that cannot be used to detect apoptosis in the physiological context of live animals. In this study, transgenic sensor zebrafish were generated that specifically produce a fluoresce...
Published in ACS sensors
Genetically encoded Förster resonance energy transfer (FRET)-based biosensors have been developed for the visualization of signaling molecule activities. Currently, most of them are comprised of cyan and yellow fluorescent proteins (CFP and YFP), precluding the use of multiple FRET biosensors within a single cell. Moreover, the FRET biosensors base...
Published in ACS sensors
In this study, an innovative gas sensing mechanism, self-responsive sensing mechanism, has been detected in the supramolecular hydrogel-based sensors. The self-responsive ability of as-fabricated hydrogel-based sensors to the target gas (e.g., NO2, NH3, etc.) is determined by three synergetic supramolecular interactions, namely, hydrogen bonding, m...
Published in ACS sensors
Currently, traumatic brain injury (TBI) is detected by medical imaging; however, medical imaging requires expensive capital equipment, is time- and resource-intensive, and is poor at predicting patient prognosis. To date, direct measurement of elevated protease activity has yet to be utilized to detect TBI. In this work, we engineered an activity-b...
Published in ACS sensors
We present the concept of a nonlinear plasmonic sensing approach for rapid, sensitive, and label-free detection of mercury. Nonlinear plasmonic sensing of mercury relies on a systematic combination of nonlinear optics (NLO) with well-known concepts of amalgamation chemistry and plasmonic properties of gold nanorods. Exploiting the extreme sensitivi...
Published in ACS sensors
In the human skin, it has been well known that several mechanoreceptors uniquely sense external stimuli with specific frequencies and magnitudes. With regard to sensitivity, the output response shows nonlinearity depending on the frequency magnitude of the stimulus. We demonstrate a self-powered proton-driven solid-state somatosensor, which mimics ...
Published in ACS sensors
Cannabinoid sensing in biofluids provides great insight into the effects of medicinal cannabis on the body. The prevalence of cannabis for pain management and illicit drug use necessitates knowledge translation in cannabinoids. In this Review, we provide an overview of the current detection methods of cannabinoids in bodily fluids emphasizing elect...
