Zheng, Yulin Cui, Xiaoting Zhou, Yunlei Zhang, Haowei Cao, Lulu Gao, Lanlan Yin, Huanshun Ai, Shiyun
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ACS sensors
Ten-eleven translocation 1 (TET1) protein has the potential to accelerate the oxygenation of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC); then the -CH2OH of 5hmC can further covalently react with -SH catalyzed by M.HhaI methyltransferase. A brand-new photoelectrochemical (PEC) detection technique for the TET1 protein was created in light of ...
Lee, Jihyun Gänswein, Tobias Ulusan, Hasan Emmenegger, Vishalini Saguner, Ardan M. Duru, Firat Hierlemann, Andreas
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ACS sensors
Pharmaceutical compounds may have cardiotoxic properties, triggering potentially life-threatening arrhythmias. To investigate proarrhythmic effects of drugs, the patch clamp technique has been used as the gold standard for characterizing the electrophysiology of cardiomyocytes in vitro . However, the applicability of this technology for drug screen...
Witthauer, Lilian Cascales, Juan Pedro Roussakis, Emmanuel Li, Xiaolei Goss, Avery Chen, Yenyu Evans, Conor L
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ACS sensors
Measurement of intramuscular oxygen could play a key role in the early diagnosis of acute compartment syndrome, a common condition occurring after severe trauma leading to ischemia and long-term consequences including rhabdomyolysis, limb loss, and death. However, to date, there is no existing oxygen sensor approved for such a purpose. To address t...
Wu, Ze Wang, Cong Liu, Bochao Liang, Chaolan Lu, Jinhui Li, Jinfeng Tang, Xi Li, Chengyao Li, Tingting
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ACS sensors
To control the coronavirus disease 2019 (COVID-19) pandemic, there is an urgent need for simple, rapid, and reliable detection methods to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially in community hospitals or clinical centers. The SARS-CoV-2 nucleocapsid protein (NP) is an important index for diagnosis...
Shi, Yuqi Hu, Yubing Jiang, Nan Yetisen, Ali K
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ACS sensors
Personalized and point-of-care (POC) diagnoses are critical for ocular physiology and disease diagnosis. Real-time monitoring and continuous sampling abilities of tear fluid and user-friendliness have become the key characteristics for the applied ophthalmic techniques. Fluorescence technologies, as one of the most popular methods that can fulfill ...
Li, Zi McNeely, Molly Sandford, Erin Tewari, Muneesh Johnson-Buck, Alexander Walter, Nils G
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ACS sensors
From longstanding techniques like enzyme-linked immunosorbent assay (ELISA) to modern next-generation sequencing, many of the most sensitive and specific biomarker detection assays require capture of the analyte at a surface. While surface-based assays provide advantages, including the ability to reduce background by washing away excess reagents an...
Ferreira, Larissa F Giordano, Gabriela F Gobbi, Angelo L Piazzetta, Maria H O Schleder, Gabriel R Lima, Renato S
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ACS sensors
The real-time and in situ monitoring of the synthesis of nanomaterials (NMs) remains a challenging task, which is of pivotal importance by assisting fundamental studies (e.g., synthesis kinetics and colloidal phenomena) and providing optimized quality control. In fact, the lack of reproducibility in the synthesis of NMs is a bottleneck against the ...
Azmi, Atiqah Nabieha Wan Ismail, Wan Zakiah Abu Hassan, Haslan Halim, Mohd Mahadi Zainal, Norzaini Muskens, Otto L Wan Ahmad Kamil, Wan Maryam
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ACS sensors
In this review, the concept of open cavity lasing for ultrasensitive sensing is explored, specifically in driving important innovations as laser-based biosensors─a field mostly dominated by fluorescence-based sensing. Laser-based sensing exhibits higher signal amplification and lower signal-to-noise ratio due to narrow emission lines as well as hig...
Yang, Jiaqi Han, Wenjiang Jiang, Bin Wang, Xi Sun, Yanfeng Wang, Wenyang Lou, Ruilin Ci, Hedi Zhang, Hong Lu, Geyu
...
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ACS sensors
Designing high-performance triethylamine gas sensors with the stable gas response and low resistance variation in air under a wide relative humidity range is expected for human health and environmental surveillance. Here, a novel porous NiO/NiFe2O4 fiber-in-tube nanostructure is prepared by the electrospinning process. The characterizations related...
Antoine, Delphine Mohammadi, Moein Vitt, Madison Dickie, Julia Marie Jyoti, Sharmin Sultana Tilbury, Maura A Johnson, Patrick A Wawrousek, Karen E Wall, J Gerard
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ACS sensors
Rapid, sensitive, on-site identification of SARS-CoV-2 infections is an important tool in the control and management of COVID-19. We have developed a surface-enhanced Raman scattering (SERS) immunoassay for highly sensitive detection of SARS-CoV-2. Single-chain Fv (scFv) recombinant antibody fragments that bind the SARS-CoV-2 spike protein were iso...
