Wu, Yue Liang, Xiaoyu Mao, Canquan Jiang, Yuhong
Published in
ACS nano
mRNA antigens require powerful nanocarriers for efficient delivery, as well as immunomodulators for controlling their excessive immunogenicity. While lipid nanoparticles (LNPs) used in mRNA vaccines exhibited systemic toxicity, there is an urgent need for developing potential nanoparticles with strong immunoenhancing effects for mRNA antigens. Alth...
Park, Wooyoung Liu, Yiming Jiao, Yanli Shi, Rui Nan, Jin Yiu, Chun Ki Huang, Xingcan Chen, Yao Li, Wenyang Gao, Yuyu
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Published in
ACS nano
Deaf-blindness limits daily human activities, especially interactive modes of audio and visual perception. Although the developed standards have been verified as alternative communication methods, they are uncommon to the nondisabled due to the complicated learning process and inefficiency in terms of communicating distance and throughput. Therefor...
Bae, Juyeol Seo, Sangjin Wu, Ronghui Kim, Taesung
Published in
ACS nano
Membrane-integrated microfluidic platforms have played a pivotal role in understanding natural phenomena coupled with solute concentration gradients at the micro- and nanoscale, enabling on-chip microscopy in well-defined planar concentration fields. However, the standardized two-dimensional fabrication schemes in microfluidics have impeded the rea...
Gao, Ping Zhang, Fei Wang, Xingchao Wu, Miaomiao Xiang, Qian Yang, Aikai Sun, Ying Guo, Jixi Huang, Yudai
Published in
ACS nano
Potassium (K) metal is considered one of the most promising anodes for potassium metal batteries (PMBs) because of its abundant and low-cost advantages but suffers from serious dendritic growth and parasitic reactions, resulting in poor cyclability, low Coulombic efficiency (CE), and safety concerns. In this work, we report a localized high-concent...
Cheng, Fangyuan Cao, Meilian Li, Qing Fang, Chun Han, Jiantao Huang, Yunhui
Published in
ACS nano
NaClO4 and NaPF6, the most universally adopted electrolyte salts in commercial sodium-ion batteries (SIBs), have a decisive influence on the interfacial chemistry, which is closely related to electrochemical performance. The complicated and ambiguous interior mechanism of microscopic interfacial chemistry has prevented reaching a consensus regardin...
Gu, Bin Xu, Qihao Wang, Hongkui Pan, Haodan Zhao, Dongliang
Published in
ACS nano
Climate change has recently caused more and more severe temperatures, inducing a growing demand for personal thermal management at outdoors. However, designing textiles that can achieve personal thermoregulation without energy consumption in severely hot and cold environments remains a huge challenge. Herein, a hierarchically nanofibrous (HNF) text...
Sun, Feng Li, Hongyun Hu, Yuru Zhang, Mengsheng Wang, Wenxu Chen, Wei Liu, Zheng
Published in
ACS nano
The geometric shape of a cell is strongly influenced by the cytoskeleton, which, in turn, is regulated by integrin-mediated cell-extracellular matrix (ECM) interactions. To investigate the mechanical role of integrin in the geometrical interplay between cells and the ECM, we proposed a single-cell micropatterning technique combined with molecular t...
Fan, Kui Yuan, Shiyi Zhou, Mi Yu, Yuan Guo, Jing Fang, Liang Zhou, Chanjuan Cui, Peijin Zhang, Siliang Li, Rong
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Published in
ACS nano
Diabetic nephropathy (DN), associated with high mobility and disability, is the leading cause of end-stage kidney disease worldwide. Dysfunction of the mammalian target of the rapamycin (mTOR) pathway and reactive oxygen species (ROS) activation in the glomeruli is the main hypnosis for DN progression. However, the use of mTOR inhibitors for DN tre...
Wei, Xiaojun Penkauskas, Tadas Reiner, Joseph E Kennard, Celeste Uline, Mark J Wang, Qian Li, Sheng Aksimentiev, Aleksei Robertson, Joseph W F Liu, Chang
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Published in
ACS nano
Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have for identifying and quantifying individual proteins are still inadequate to perform protein sequencing at the single-molecule level. Nanopore-inspired systems devoted to understanding how single molecules behave have been...
Fletcher, R Brock Stokes, Larry D Kelly, Isom B 3rd Henderson, Katelyn M Vallecillo-Viejo, Isabel C Colazo, Juan M Wong, Benjamin V Yu, Fang d'Arcy, Richard Struthers, Morgan N
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Published in
ACS nano
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge, efficiently load into porous silicon nanoparticles (PSiNPs). Optimizing the loading strategy yields formulations that are ultrahigh loading─>40% cargo by volume─and hig...