Li, Lu Zhou, Rongsheng Lv, Haigang Song, Lei Xue, Xiaohong Wu, Li
Published in
ACS chemical neuroscience
Luteolin is a flavone compound occurring in a variety of medicinal plants, which is reported to have neuroprotective properties. In this study, we aimed to explore the effects of luteolin in alleviating sevoflurane-induced neurotoxicity. GeneCards and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform were employed to ...
Hoffmann, Chris Evcüman, Sibel Neumaier, Felix Zlatopolskiy, Boris D Humpert, Swen Bier, Dirk Holschbach, Marcus Schulze, Annette Endepols, Heike Neumaier, Bernd
...
Published in
ACS chemical neuroscience
Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-d-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsych...
Liu, Lian Liu, Ming Zhao, Wei Zhao, Yuan-Ling Wang, Yun
Published in
ACS chemical neuroscience
Tetrahydropalmatine (THP) has analgesic, hypnotic, sedative, and other pharmacological effects. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, growth, and development. However, their mechanism of action in methamphetamine (MA)-induced neurotoxicity remains unclear. This study aims to explore the important r...
Wakabayashi, Ken T Greeman, Esther A Barrett, Scott T Bevins, Rick A
Published in
ACS chemical neuroscience
While sugar consumption and alcohol drinking have traditionally been studied by different basic science fields, most commercially available flavored alcoholic beverages are sweetened with some kind of sugar. The prevailing view is that these sugars potentiate drinking by making the alcohol taste better, particularly for adolescents, overlooking tha...
Bie, Nana Feng, Xiaojuan Li, Chenjing Meng, Meng Wang, Chunling
Published in
ACS chemical neuroscience
Docosahexaenoic acid (DHA) has attracted plenty of interest in the prevention of neurodegenerative diseases. Although the beneficial effects of DHA on the central nervous system function are recognized, more information on the molecular mechanisms involved in its neuroprotective effects is required. The present study aimed to evaluate the effects o...
Brown, Josephine M Baker, Lauren S Seroogy, Kim B Genter, Mary Beth
Published in
ACS chemical neuroscience
Parkinson's disease (PD) is a debilitating neurodegenerative disorder. Early symptoms include motor dysfunction and impaired olfaction. Toxic aggregation of α-synuclein (aSyn) in the olfactory bulb (OB) and substantia nigra pars compacta (SNpc) is a hallmark of PD neuropathology. Intranasal (IN) carnosine (2 mg/d for 8 weeks) was previously demonst...
Santur, Karoline Reinartz, Elke Lien, Yi Tusche, Markus Altendorf, Tim Sevenich, Marc Tamgüney, Gültekin Mohrlüder, Jeannine Willbold, Dieter
Published in
ACS chemical neuroscience
A common characteristic of familial (fALS) and sporadic amyotrophic lateral sclerosis (sALS) is the accumulation of aberrant proteinaceous species in the motor neurons and spinal cord of ALS patients-including aggregates of the human superoxide dismutase 1 (hSOD1). hSOD1 is an enzyme that occurs as a stable dimeric protein with several post-transla...
P, Prabitha Justin, Antony Ananda Kumar, T Durai Chinaswamy, Mithuna Kumar, B R Prashantha
Published in
ACS chemical neuroscience
Understanding various aspects of Parkinson's disease (PD) by researchers could lead to a better understanding of the disease and provide treatment alternatives that could significantly improve the quality of life of patients suffering from neurodegenerative disorders. Significant progress has been made in recent years toward this goal, but there is...
Li, Gao Zhou, Yu Yang, Wu-Yue Zhang, Chen Hong, Liu Jia, Lee
Published in
ACS chemical neuroscience
Abnormal aggregation and deposition of Aβ is one of the causative agents for Alzheimer's disease. The development of inhibitors for Aβ aggregation has been considered a possible method to prevent and treat Alzheimer's disease. Edible sea cucumbers contain many bioactive molecules, including saponins, phospholipids, peptides, and polysaccharides. He...
Ji, Beihong Xue, Ying Xu, Yuanyuan Liu, Shuhan Gough, Albert H Xie, Xiang Qun Wang, Junmei
Published in
ACS chemical neuroscience
