Campora, Marta Canale, Claudio Gatta, Elena Tasso, Bruno Laurini, Erik Relini, Annalisa Pricl, Sabrina Catto, Marco Tonelli, Michele
Published in
ACS chemical neuroscience
Two series of naphthoquinone and anthraquinone derivatives decorated with an aromatic/heteroaromatic chain have been synthesized and evaluated as potential promiscuous agents capable of targeting different factors playing a key role in Alzheimer's disease (AD) pathogenesis. On the basis of the in vitro biological profiling, most of them exhibited a...
Dong, Jing Fu, Hui Fu, Yuanyuan You, Mingdan Li, Xudong Wang, Chaonan Leng, Kunkun Wang, Yuan Chen, Jie
Published in
ACS chemical neuroscience
Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of plasticizer, can result in neurodevelopment impairments and learning and memory disorders. We studied the effects and possible mechanisms of maternal DEHP treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats were randomly divided into four groups and re...
Strong, Katie L Epplin, Matthew P Ogden, Kevin K Burger, Pieter B Kaiser, Thomas M Wilding, Timothy J Kusumoto, Hiro Camp, Chad R Shaulsky, Gil Bhattacharya, Subhrajit
...
Published in
ACS chemical neuroscience
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has driven therapeutic interest in positive allosteric modulators (PAMs) of NMDAR function. Here we descr...
Ansari, Abdul Haque Pal, Ajay Ramamurthy, Aditya Kabat, Maciej Jain, Suman Kumar, Suneel
Published in
ACS chemical neuroscience
Fibromyalgia is a musculoskeletal pain of different parts of the body, which is also associated with fatigue, lack of sleep, cognition deficits, family history, gender bias, and other disorders such as osteoarthritis and rheumatoid arthritis. It is generally initiated after trauma, surgery, infection, or stress. Fibromyalgia often coexists with sev...
Lawaczeck, Rüdiger
Published in
ACS chemical neuroscience
To provide solid information about viral infection, disease, and body iron metabolism, the literature was surveyed for mutual correlations. Gender and age profiles of COVID-19 infection and disease correlate well with the profiles of serum iron and ferritin with correlation coefficients ≥ 0.75. There are further symptomatic hints that the ABO blood...
Kaide, Sho Watanabe, Hiroyuki Shimizu, Yoichi Iikuni, Shimpei Nakamoto, Yuji Hasegawa, Masato Itoh, Kyoko Ono, Masahiro
Published in
ACS chemical neuroscience
α-Synuclein (α-syn) aggregates are pathologically associated with the hallmarks found in brains affected by synucleinopathies such as Parkinson's disease (PD) and multiple system atrophy (MSA). Therefore, the in vivo detection of α-syn aggregates using radiolabeled probes is useful for the comprehension of and medical intervention for synucleinopat...
Bhat, Abid Tan, Vanessa Heng, Benjamin Lovejoy, David B Sakharkar, Meena Kishore Essa, Musthafa Mohamed Chidambaram, Saravana Babu Guillemin, Gilles J
Published in
ACS chemical neuroscience
The overexpression of phosphodiesterase 4 (PDE4) enzymes is reported in several neurodegenerative diseases. PDE4 depletes cyclic 3'-5' adenosine monophosphate (cAMP) and, in turn, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF), the key players in cognitive function. The present study was undertaken to inve...
Montaser, Ahmed B Järvinen, Juulia Löffler, Susanne Huttunen, Johanna Auriola, Seppo Lehtonen, Marko Jalkanen, Aaro Huttunen, Kristiina M
Published in
ACS chemical neuroscience
Membrane transporters have long been utilized to improve the oral, hepatic, and renal (re)absorption. In the brain, however, the transporter-mediated drug delivery has not yet been fully achieved due to the complexity of the blood-brain barrier (BBB). Because L-type amino acid transporter 1 (LAT1) is a good candidate to improve the brain delivery, ...
Akki, Rachid Fath, Nada Mohti, Hicham
Published in
ACS chemical neuroscience
This Article summarizes the likely benefits of central nervous system oxidative preconditioning in the reduction of COVID-19 based on its putative pathogenesis. The current COVID-19 outbreak caused a pandemic with millions of infected patients and death cases worldwide. The clinical features of severe acute respiratory syndrome coronavirus (SARS-Co...
Frank, James A Antonini, Marc-Joseph Chiang, Po-Han Canales, Andres Konrad, David B Garwood, Indie C Rajic, Gabriela Koehler, Florian Fink, Yoel Anikeeva, Polina
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Published in
ACS chemical neuroscience
Photoswitchable ligands can add an optical switch to a target receptor or signaling cascade and enable reversible control of neural circuits. The application of this approach, termed photopharmacology, to behavioral experiments has been impeded by a lack of integrated hardware capable of delivering both light and compounds to deep brain regions in ...
