Garcia Garcia, Cristobal Patkar, Sai S Jovic, Nina Mittal, Jeetain Kiick, Kristi L
Published in
ACS biomaterials science & engineering
Heterogeneities in hydrogel scaffolds are known to impact the performance of cells in cell-laden materials constructs, and we have employed the phase separation of resilin-like polypeptides (RLPs) as a means to generate such materials. Here, we study the compositional features of resilin-like polypeptides (RLPs) that further enable our control of t...
Ravikrishnan, Anitha Fowler, Eric W Stuffer, Alexander J Jia, Xinqiao
Published in
ACS biomaterials science & engineering
There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options. Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used...
Muir, Victoria G Qazi, Taimoor H Shan, Junwen Groll, Jürgen Burdick, Jason A
Published in
ACS biomaterials science & engineering
Bulk hydrogels traditionally used for tissue engineering and drug delivery have numerous limitations, such as restricted injectability and a nanoscale porosity that reduces cell invasion and mass transport. An evolving approach to address these limitations is the fabrication of hydrogel microparticles (i.e., "microgels") that can be assembled into ...
Vandelannoote, Koen Buultjens, Andrew H Li, Lucy Sharkey, Liam K Herisse, Marion Pidot, Sacha J Hoang, Tuyet Howden, Benjamin P Monk, Ian R Seemann, Torsten
...
Published in
ACS biomaterials science & engineering
The COVID-19 pandemic has exposed the dependence of diagnostic laboratories on a handful of large corporations with market monopolies on the worldwide supply of reagents, consumables, and hardware for molecular diagnostics. Global shortages of key consumables for RT-qPCR detection of SARS-CoV-2 RNA have impaired the ability to run essential, routin...
Bovone, Giovanni Dudaryeva, Oksana Y Marco-Dufort, Bruno Tibbitt, Mark W
Published in
ACS biomaterials science & engineering
Hydrogel adhesion inherently relies on engineering the contact surface at soft and hydrated interfaces. Upon contact, adhesion normally occurs through the formation of chemical or physical interactions between the disparate surfaces. The ability to form these adhesion junctions is challenging for hydrogels as the interfaces are wet and deformable a...
Lee, Hyun Jin Mun, Siwon Pham, Duc M Kim, Pilnam
Published in
ACS biomaterials science & engineering
When embedded into a three-dimensional (3D) matrix, cancer stem cells (or cancer-initiating cells) can grow into self-organizing organotypic structures called tumor organoids. During organoid formation, the matrix not only provides structural support but also delivers biochemical signals. Although increasing evidence indicates that the extracellula...
Park, Eunsook Ryu, Ji Hyun Lee, Daiheon Lee, Haeshin
Published in
ACS biomaterials science & engineering
Catechol-containing hydrogels have been exploited in biomedical fields due to their adhesive and cohesive properties, hemostatic abilities, and biocompatibility. Catechol moieties can be oxidized to o-catecholquinone, a chemically active intermediate, in the presence of oxygen to act as an electrophile to form catechol-catechol or catechol-amine/th...
Aldana, Ana A Houben, Sofie Moroni, Lorenzo Baker, Matthew B Pitet, Louis M
Published in
ACS biomaterials science & engineering
Additive manufacturing and injection are essential tools in the rapidly developing field of personalized medicine and are particularly promising for applications in regenerative medicine. One of the biggest challenges in this vibrant research domain remains the processing of complex formulations with robust mechanical properties. Mimicking the nati...
Peressotti, Sofia Koehl, Gillian E Goding, Josef A Green, Rylie A
Published in
ACS biomaterials science & engineering
Hydrogel materials have been employed as biological scaffolds for tissue regeneration across a wide range of applications. Their versatility and biomimetic properties make them an optimal choice for treating the complex and delicate milieu of neural tissue damage. Aside from finely tailored hydrogel properties, which aim to mimic healthy physiologi...
Shin, Jisoo Kang, Eun Hye Choi, Soojeong Jeon, Eun Je Cho, Jung Ho Kang, Donyoung Lee, Hyungsuk Yun, In Sik Cho, Seung-Woo
Published in
ACS biomaterials science & engineering
Chondroitin sulfate (CS), the main component of cartilage extracellular matrix, has attracted attention as a biomaterial for cartilage tissue engineering. However, current CS hydrogel systems still have limitations for application in successful cartilage tissue engineering owing to their unsuitable degradation kinetics, insufficient mechanical simi...
