Ågren, Richard Zeberg, Hugo Stępniewski, Tomasz Maciej Free, R Benjamin Reilly, Sean W Luedtke, Robert R Århem, Peter Ciruela, Francisco Sibley, David R Mach, Robert H
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Published in
ACS chemical neuroscience
A solid understanding of the mechanisms governing ligand binding is crucial for rational design of therapeutics targeting the dopamine D2 receptor (D2R). Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus oocytes to measure the kinetics of D2R antagonism by a series of aripiprazole analogues, as well as t...
Butowt, Rafal Bilinska, Katarzyna Von Bartheld, Christopher S.
Published in
ACS Chemical Neuroscience
After several months of rapid pandemic expansion, it is now apparent that the SARS-CoV-2 coronavirus interferes with smell and taste sensation in a substantial proportion of COVID-19 patients. Recent epidemiological data documented intriguing differences in prevalence of chemosensory dysfunctions between different world regions. Viral genetic facto...
Stiebing, Clara Jahn, Izabella J. Schmitt, Michael Keijzer, Nanda Kleemann, Robert Kiliaan, Amanda J. Drexler, Wolfgang Leitgeb, Rainer A. Popp, Jürgen
Published in
ACS Chemical Neuroscience
The presence of biomarkers characteristic for Alzheimer’s disease in the retina is a controversial topic. Raman spectroscopy offers information on the biochemical composition of tissues. Thus, it could give valuable insight into the diagnostic value of retinal analysis. Within the present study, retinas of a double transgenic mouse model, that expr...
Stephens, Amberley D. Lu, Meng Fernandez-Villegas, Ana Kaminski Schierle, Gabriele S.
Published in
ACS Chemical Neuroscience
The Alzheimer’s disease related peptide, Amyloid-beta (Aβ)1–40 and 1–42, has proven difficult to be purified as a recombinant monomeric protein due its expression in E. coli leading to the formation of insoluble inclusion bodies and its tendency to quickly form insoluble aggregates. A vast array of methods have been used so far, yet many have pitfa...
Barrantes, Francisco J.
Published in
ACS Chemical Neuroscience
As the coronavirus disease 2019 (COVID-19) pandemic unfolds, neurological signs and symptoms reflect the involvement of targets beyond the primary lung effects. The etiological agent of COVID-19, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits neurotropism for central and peripheral nervous systems. Various infective mech...
Siddiqui, Ruqaiyyah Khamis, Mustafa Ibrahim, Taleb Khan, Naveed Ahmed
Published in
ACS Chemical Neuroscience
The presence of SARS-CoV-2 in human wastewater together with poor quality of public drinking water supplies in developing countries is of concern. Additionally, the frequent use of contaminated water for bathing, nasal irrigation, swimming, and ablution can be a risk factor in contracting infectious agents such as the brain-eating amoebae and possi...
Cazzolla, Angela P. Lovero, Roberto Lo Muzio, Lorenzo Testa, Nunzio F. Schirinzi, Annalisa Palmieri, Giuseppe Pozzessere, Pietro Procacci, Vito Di Comite, Mariasevera Ciavarella, Domenico
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Published in
ACS Chemical Neuroscience
The rapid recovery of smell and taste functions in COVID-19 patients could be attributed to a decrease in interleukin-6 levels rather than central nervous system ischemic injury or viral damage to neuronal cells. To correlate interleukin-6 levels in COVID-19 patients with olfactory or gustatory dysfunctions and to investigate the role of IL-6 in th...
Alharthy, Abdulrahman Faqihi, Fahad Memish, Ziad A. Karakitsos, Dimitrios
Published in
ACS Chemical Neuroscience
Immune system and renin-angiotensin-aldosterone system dysregulation with associated cytokine release syndrome may be a key feature of early stage of SARS-CoV-2 organotropism and infection. Following viral mediated brain injury, dysregulated neurochemical activity may cause neurogenic stress cardiomyopathy, which is characterized by transient myoca...
Alharthy, Abdulrahman Faqihi, Fahad Memish, Ziad A. Karakitsos, Dimitrios
Published in
ACS Chemical Neuroscience
Lung injury with COVID-19 may be due to a complex underlying pathophysiology. Cytokine release syndrome appears to be a catalyst of different inflammatory pathways promoting lung parenchymal injury and thromboembolic phenomena (“dual hit” injury). Recently, severe neurological manifestations such as acute disseminated encephalomyelitis, which may b...
Bilinska, Katarzyna Butowt, Rafal
Published in
ACS Chemical Neuroscience
It has become clear since the pandemic broke out that SARS-CoV-2 virus causes reduction of smell and taste in a significant fraction of COVID-19 patients. The olfactory dysfunction often occurs early in the course of the disease, and sometimes it is the only symptom in otherwise asymptomatic carriers. The cellular mechanisms for these specific olfa...
