Gandhi, Sonu Srivastava, Amit Kumar Ray, Upasana Tripathi, Prem Prakash
Published in
ACS Chemical Neuroscience
Following the identification of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, we are now again facing a global highly pathogenic novel coronavirus (SARS-CoV-2) epidemic. Although the lungs are one of the most critically affected organs, several other organs, inc...
Baig, Abdul Mannan
Published in
ACS Chemical Neuroscience
With the ongoing pandemic of coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), our knowledge of the pathogenesis of COVID-19 is still in its infancy. Almost every aspect of the pathogen remains largely unknown, ranging from mechanisms involved in infection transmission, interplay with the human i...
Das, Gaurav Mukherjee, Nabanita Ghosh, Surajit
Published in
ACS Chemical Neuroscience
The novel coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has kept the whole world in tenterhooks due to its severe life-threatening nature of the infection. The virus is unlike its previous counterparts, SARS-CoV and MERS-CoV, or anything the world has encountered before both in terms of viru...
Butowt, Rafal Bilinska, Katarzyna
Published in
ACS Chemical Neuroscience
The novel SARS-CoV-2 virus has very high infectivity, which allows it to spread rapidly around the world. Attempts at slowing the pandemic at this stage depend on the number and quality of diagnostic tests performed. We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at ...
Toljan, Karlo
Published in
ACS Chemical Neuroscience
Mostyn, Shannon N. Sarker, Subhodeep Muthuraman, Parthasarathy Raja, Arun Shimmon, Susan Rawling, Tristan Cioffi, Christopher L. Vandenberg, Robert J.
Published in
ACS Chemical Neuroscience
Glycine neurotransmission in the dorsal horn of the spinal cord plays a key role in regulating nociceptive signaling, but in chronic pain states reduced glycine neurotransmission is associated with the development of allodynia and hypersensitivity to painful stimuli. This suggests that restoration of glycine neurotransmission may be therapeutic for...
Baig, Abdul Mannan Khaleeq, Areeba Ali, Usman Syeda, Hira
Published in
ACS Chemical Neuroscience
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from th...
Parkkila, Petteri Viitala, Tapani
Published in
ACS Chemical Neuroscience
We have utilized multiparametric surface plasmon resonance and impendance-based quartz crystal microbalance instruments to study the distribution coefficients of catechol derivatives in cell model membranes. Our findings verify that the octanol–water partitioning coefficient is a poor descriptor of the total lipid affinity for small molecules which...
Asad, Naeem McLain, Duncan E. Condon, Alec F. Gore, Sangram Hampton, Shahienaz E. Vijay, Sauparnika Williams, John T. Dore, Timothy M.
Published in
ACS Chemical Neuroscience
Kinetic analysis of dopamine receptor activation and inactivation and the study of dopamine-dependent signaling requires precise simulation of the presynaptic release of the neurotransmitter dopamine and tight temporal control over the release of dopamine receptor antagonists. The 8-cyano-7-hydroxyquinolinyl (CyHQ) photoremovable protecting group w...
Philipsen, Mai Hoang Phan, Nhu T. N. Fletcher, John Stephen Ewing, Andrew G.
Published in
ACS Chemical Neuroscience
Cocaine dependence displays a broad impairment in cognitive performance including attention, learning, and memory. To obtain a better understanding of the action of cocaine in the nervous system, and the relation between phospholipids and memory, we have investigated whether phospholipids recover in the brain following cocaine removal using the fly...
