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Zhu Wang A, Mitrofanova Sk, Bergren C, Abate-Shen Rd, Cardiff A, Califano Mm, Shen
Published in
Nature Cell Biology
A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour subtypes that differ in their prognosis and/or treatment response. We now show that initiation of prostate tumours in basal or luminal epithelial cells in mouse models results in tumours with disti...
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Zhu Wang R, Toivanen Sk, Bergren P, Chambon Mm, Shen
Published in
Cell Reports
The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or luminal epithelial cells, or both, represent cells of origin under physiological conditions in vivo. ...
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Zhu Wang J, Huang D, Kalderon
Published in
Nature Communications
The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...
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Pa, Mieczkowski Ra, Moore Le, Mose Aj, Mungall A, Pantazi M, Parfenov Pj, Park Js, Parker Cm, Perou A, Protopopov
...
Published in
New England Journal of Medicine
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Zhu Wang D, Kalderon
Published in
Proceedings of the National Academy of Sciences
Whether stem cells have unique cell cycle machineries and how they integrate with niche interactions remains largely unknown. We identified a hypomorphic cyclin E allele WX that strongly impairs the maintenance of follicle stem cells (FSCs) in the Drosophila ovary but does not reduce follicle cell proliferation or germline stem cell maintenance. Cy...
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Zhu Wang Mm, Shen
Published in
Molecular & Cellular Oncology
The interplay of different cell types of origin and distinct oncogenic mutations may determine the tumor subtype. We have recently found that although both basal and luminal epithelial cells can initiate prostate tumorigenesis, the latter are more likely to undergo transformation in response to a range of oncogenic events.
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Cm, Perou J, Roach Je, Schein Se, Schumacher Y, Shi Jv, Simons P, Sipahimalani T, Skelly Mg, Soloway C, Sougnez
...
Published in
New England Journal of Medicine
Are you sure you are not the author of this publication?
Zhu Wang Mm, Shen
Published in
Molecular & Cellular Oncology
The interplay of different cell types of origin and distinct oncogenic mutations may determine the tumor subtype. We have recently found that although both basal and luminal epithelial cells can initiate prostate tumorigenesis, the latter are more likely to undergo transformation in response to a range of oncogenic events.
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Network, Cancer Genome Atlas Research Wm, Linehan Pt, Spellman Cj, Ricketts Cj, Creighton Ss, Fei C, Davis Da, Wheeler Ba, Murray L, Schmidt
...
Published in
New England Journal of Medicine
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Zhu Wang Mm, Shen
Published in
Oncogene
The cancer stem cell (CSC) model proposes that cells within a tumor are organized in a hierarchical lineage relationship and display different tumorigenic potential, suggesting that effective therapeutics should target rare CSCs that sustain tumor malignancy. Here we review the current status of studies to identify CSCs in human prostate cancer as ...
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H, Kim Kw, Kim Hj, Kim S, Cho N, Li Y, Huang Mw, Bruford X, Zhan A, Dixon Mf, Bertelsen
...
Published in
Science
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific...
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Al, Martins A, Siepel A, Roychoudhury X, Ma J, Degenhardt Cd, Bustamante Rn, Gutenkunst T, Mailund Jy, Dutheil A, Hobolth
...
Published in
Nature
Orang-utan is derived from a Malay term meaning man of the forest and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evol...
Are you sure you are not the author of this publication?
Zhu Wang A, Mitrofanova Sk, Bergren C, Abate-Shen Rd, Cardiff A, Califano Mm, Shen
Published in
Nature Cell Biology
A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour subtypes that differ in their prognosis and/or treatment response. We now show that initiation of prostate tumours in basal or luminal epithelial cells in mouse models results in tumours with disti...
Are you sure you are not the author of this publication?
S, Sadeghi Ml, Cohen J, Eschbacher Em, Hattab A, Raghunathan Mj, Schniederjan D, Aziz G, Barnett W, Barrett Dd, Bigner
...
Published in
New England Journal of Medicine
Are you sure you are not the author of this publication?
Zhu Wang J, Huang D, Kalderon
Published in
Nature Communications
The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as ...
Are you sure you are not the author of this publication?
Dp, Locke Lw, Hillier Wc, Warren Kc, Worley Lv, Nazareth Dm, Muzny Sp, Yang Zhu Wang At, Chinwalla P, Minx
...
Published in
Nature
Orang-utan is derived from a Malay term meaning man of the forest and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evol...
Are you sure you are not the author of this publication?
Zhu Wang D, Kalderon
Published in
Proceedings of the National Academy of Sciences
Whether stem cells have unique cell cycle machineries and how they integrate with niche interactions remains largely unknown. We identified a hypomorphic cyclin E allele WX that strongly impairs the maintenance of follicle stem cells (FSCs) in the Drosophila ovary but does not reduce follicle cell proliferation or germline stem cell maintenance. Cy...
Are you sure you are not the author of this publication?
Zhu Wang Mm, Shen
Published in
Oncogene
The cancer stem cell (CSC) model proposes that cells within a tumor are organized in a hierarchical lineage relationship and display different tumorigenic potential, suggesting that effective therapeutics should target rare CSCs that sustain tumor malignancy. Here we review the current status of studies to identify CSCs in human prostate cancer as ...
Are you sure you are not the author of this publication?
Zhu Wang R, Toivanen Sk, Bergren P, Chambon Mm, Shen
Published in
Cell Reports
The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or luminal epithelial cells, or both, represent cells of origin under physiological conditions in vivo. ...
Are you sure you are not the author of this publication?
G, Zhang C, Li Q, Li B, Li Dm, Larkin C, Lee Jf, Storz A, Antunes Mj, Greenwold Rw, Meredith
...
Published in
Science
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific...
