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Yao-Hui Sun Brian Reid Jh, Fontaine La, Miller Dm, Hyde A, Mogilner Min Zhao
Published in
Journal of Applied Physiology
Damage to the respiratory epithelium is one of the most critical steps to many life-threatening diseases, such as acute respiratory distress syndrome and chronic obstructive pulmonary disease. The mechanisms underlying repair of the damaged epithelium have not yet been fully elucidated. Here we provide experimental evidence suggesting a novel mecha...
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Kan Zhu Yao-Hui Sun A, Miu M, Yen B, Liu Q, Zeng A, Mogilner Min Zhao
Published in
Journal of Cellular Physiology
Cell fragments devoid of the nucleus and major organelles are found in physiology and pathology, for example platelets derived from megakaryocytes, and cell fragments from white blood cells and glioma cells. Platelets exhibit active chemotaxis. Fragments from white blood cells display chemotaxis, phagocytosis, and bactericidal functions. Signaling ...
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L, Li R, Hartley B, Reiss Yao-Hui Sun J, Pu D, Wu Francis Lin T, Hoang S, Yamada J, Jiang
...
Published in
Cellular and Molecular Life Sciences
In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...
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Vu, Tran Xiaodong, Zhang Lin, Cao Hanqing, Li Benjamin, Lee Michelle, So Yao-Hui Sun Wei, Chen Min Zhao
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Jc, Rudell J, Gao Yao-Hui Sun Yao-Hui Sun J, Chodosh I, Schwab Min Zhao
Published in
Investigative Ophthalmology & Visual Science
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Rc, Gao Xd, Zhang Yao-Hui Sun Y, Kamimura A, Mogilner Pn, Devreotes Min Zhao
Published in
Eukaryotic Cell
Many types of cells migrate directionally in direct current (DC) electric fields (EFs), a phenomenon termed galvanotaxis or electrotaxis. The directional sensing mechanisms responsible for this response to EFs, however, remain unknown. Exposing cells to an EF causes changes in plasma membrane potentials (V(m)). Exploiting the ability of Dictyosteli...
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O, Hoeller Je, Toettcher H, Cai Yao-Hui Sun Ch, Huang M, Freyre Min Zhao Pn, Devreotes Od, Weiner
Published in
PLoS Biology
For directional movement, eukaryotic cells depend on the proper organization of their actin cytoskeleton. This engine of motility is made up of highly dynamic nonequilibrium actin structures such as flashes, oscillations, and traveling waves. In Dictyostelium, oscillatory actin foci interact with signals such as Ras and phosphatidylinositol 3,4,5-t...
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Yao-Hui Sun H, Do J, Gao R, Zhao Min Zhao A, Mogilner
Published in
Current Biology
Sensing of an electric field (EF) by cells-galvanotaxis-is important in wound healing [1], development [2], cell division, nerve growth, and angiogenesis [3]. Different cell types migrate in opposite directions in EFs [4], and the same cell can switch the directionality depending on conditions [5]. A tug-of-war mechanism between multiple signaling ...
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Kenichi Nakajima Kan Zhu Yao-Hui Sun B, Hegyi Q, Zeng Cj, Murphy Jv, Small Y, Chen-Izu Y, Izumiya Jm, Penninger
...
Published in
Nature Communications
Weak electric fields guide cell migration, known as galvanotaxis/electrotaxis. The sensor(s) cells use to detect the fields remain elusive. Here we perform a large-scale screen using an RNAi library targeting ion transporters in human cells. We identify 18 genes that show either defective or increased galvanotaxis after knockdown. Knockdown of the ...
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Yao-Hui Sun Yao-Hui Sun Kan Zhu Bw, Draper Q, Zeng A, Mogilner Min Zhao
Published in
Methods in Molecular Biology
Recent studies have demonstrated distinctive motility and responses to extracellular cues of cells in isolation, cells collectively in groups, and cell fragments. Here we provide a protocol for generating cell sheets, isolated cells, and cell fragments of keratocytes from zebrafish scales. The protocol starts with a comprehensive fish preparation, ...
