Valérie Paradis

IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans

Published in PLoS Genetics

Neurotensin regulation induces overexpression and activation of EGFR in HCC and restores response to erlotinib and soraf...

Published in International Journal of Radiation Applications and Instrumentation Part D Nuclear Tracks and Radiation Measurements

Epithelial-mesenchymal transition in cholangiocarcinoma: from clinical evidence to regulatory networks

Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of the patients are not eligible for curative surgery owing to the presence of metastases at the time of diagnosis. Therefore, it is important to understand the steps leadi...

Anti-angiogenic effect of metformin in human liver carcinogenesis related to metabolic syndrome.

Published in Journal of Neurology Neurosurgery & Psychiatry

Follow-up Imaging After Liver Transplantation Should Take Into Consideration Primary Hepatocellular Carcinoma Characteri...

Published in Trends in Immunology

Both pattern and delay of HCC recurrence support performing regular whole-body imaging initially every 6 to 12 months and continuing beyond 2 years after LT for HCC, especially in patients with pejorative pathological features of the primary tumor that could influence HCC recurrence pattern.

Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rat...

Published in Obesity Surgery

Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemothe...

Published in Frontiers in Immunology

Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we...

Well-differentiated hepatocellular neoplasm of uncertain malignant potential.

Published in Annales Médico-psychologiques revue psychiatrique

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease.

Published in British Journal of Dermatology

Polyploidization is one of the most dramatic changes that can occur in the genome. In the liver, physiological polyploidization events occur during both liver development and throughout adult life. Here, we determined that a pathological polyploidization takes place in nonalcoholic fatty liver disease (NAFLD), a widespread hepatic metabolic disorde...

Interactions between virus-related factors and post-transplant ascites in patients with hepatitis C and no cirrhosis: ro...

Published in Sante Ment Que

Refractory ascites may appear in liver transplant recipients with recurrence of hepatitis C virus infection, even in the absence of advanced fibrosis. The mechanisms are unclear. The aim was to determine whether post-transplant cryoglobulinemia could be a predisposing factor for ascites in this population. Retrospective data of 82 liver transplant ...

In vivo anisotropic mechanical properties of dystrophic skeletal muscles measured by anisotropic MR elastographic imagin...

Published in Journal of Medical Genetics

The mechanical anisotropic ratio of the shear storage moduli measured by an anisotropic MR elastographic technique can distinguish between healthy muscle and dystrophic muscle.

Diagnosis and management of solid benign liver lesions.

Published in Horizontal Gene Transfer

More and more asymptomatic benign liver tumours are discovered incidentally and can be divided into regenerative lesions and true neoplastic lesions. The most common regenerative lesions include hemangioma, focal nodular hyperplasia and inflammatory pseudotumours of the liver. Neoplastic lesions include hepatocellular adenomas and angiomyolipomas. ...

Progression from cirrhosis to cancer is associated with early ubiquitin post-translational modifications: identification...

Published in Clinical Oral Implants Research

Cirrhosis is a lesion at risk of hepatocellular carcinoma (HCC). Identifying mechanisms associated with the transition from cirrhosis to HCC and characterizing biomarkers of cirrhosis at high risk of developing into cancer are crucial for improving early diagnosis and prognosis of HCC. We used MALDI imaging to compare mass spectra obtained from tis...

Congenital hepatic fibrosis with multiple HNF1α hepatocellular adenomas.

Published in Critical Care Medicine

Complete spontaneous liver graft disappearance after auxiliary liver transplantation.

Published in The Journal of Clinical Endocrinology & Metabolism

In situ proteomic analysis by MALDI imaging identifies ubiquitin and thymosin-β4 as markers of malignant intraductal pan...

Published in Cancer Cell

Ubiquitin and thymosin-β4 are overexpressed in IPMN with high grade dysplasia. Positive immunochemical staining on EUS-FNA material is a major argument in support of preventive resection.

Viscoelastic parameters for quantifying liver fibrosis: three-dimensional multifrequency MR elastography study on thin l...

Our high resolution, three-dimensional multifrequency MR elastography study of thin liver slices shows that the storage modulus is the viscoelastic parameter that has the best association with the severity of liver fibrosis. However, its diagnostic performance does not differ significantly from that of the complex shear modulus.

Tumoral heterogeneity of hepatic cholangiocarcinomas revealed by MALDI imaging mass spectrometry.

Published in The American Journal of Cardiology

Cholangiocarcinoma (CC) is the second most common primary malignancy of the liver. Although all CC derive from biliary epithelial cells, two main subtypes, hilar (H), and peripheral (P) CC are described. The objective of the study was to compare, using MALDI imaging mass spectrometry (MALDI IMS), in situ proteomic profiles of H- and P-CC in order t...

Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocell...

Published in The Journal of Clinical Endocrinology & Metabolism

These results demonstrate the potential of MALDI IMS for uncovering new relevant biomarkers of MiVI in HCC, and highlight the role of epigenetic modifications in the prognosis of HCC. Preoperative detection of modified forms of histone H4 expression in tumor biopsies would be helpful in management of patients with HCC.