Valentina Kouznetsova

bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design.

Published in Current Topics in Medicinal Chemistry

Numerous basic-helix-loop-helix (bHLH) transcription factors (TF) have been found to play important roles in tumor growth and progression. Elucidation of the common features of these TFs can pave the road to possible therapeutic intervention. The existing studies of possible inhibition of these TFs are concentrated on the development of peptides or...

Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI.

Published in ACS Nano

Scavenger receptors (SRs) are molecular pattern recognition receptors that have been shown to mediate opsonin-independent uptake of therapeutic and imaging nanoparticles, underlying the importance of SRs in nanomedicine. Unlike pathogens, engineered nanomaterials offer great flexibility in control of surface properties, allowing addressing specific...

Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma.

Published in Molecular BioSystems

Glioblastoma is a highly-aggressive and rapidly-lethal tumor characterized by resistance to therapy. Although data on multiple genes, proteins, and pathways are available, the key challenge is deciphering this information and identifying central molecular targets. Therapeutically targeting individual molecules is often unsuccessful due to the prese...

Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.

Published in Oncotarget