Published in Tissue Engineering Part A
We designed a sheet-like bone substitute capable of adapting to different geometries and becoming a standard tissue-engineered process for bone surgery. Preosteoblastic cells were seeded on to a monolayer of calcium phosphate granules and cultured in a flat parallelepipedic cell culture chamber for 1 month. From the various diameters of the granule...
Bone tissue engineering requests a balance among at least three factors: cells, scaffold and environmental factors such as mechanical stresses. The characterization of both biological and mechanical properties of in vitro-built tissues might be useful to understand its in vivo behaviour after implantation. For the development of a bone substitute f...
L’ingénierie tissulaire implique une coopération étroite entre trois acteurs : les cellules, les sollicitations qu’elles perçoivent et le support de culture. Les caractéristiques mécaniques et biologiques du tissu reconstruit in vitro doivent être évaluées pour connaître son comportement in vivo face aux stimuli rencontrés après imp...