The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
Published in Cell Metabolism
FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS) and major determinants of aging in organisms ranging from worms to man. The molecular mechanisms that actively promote DAF16/FOXO stability and function are unknown. Here we identify the deubiquitylating enzyme MATH-33 as an essential DAF-16 regulator in IIS...
